Effect of amlodipine on morbidity and mortality in severe chronic heart failure

New England Journal of Medicine

Volumn 335, Issue 15, 1996, Pages 1107-1114

  Packer, Milton ^a   O'Connor, Christopher M ^b   Ghali, Jalal K ^c   Pressler, Milton L ^d   Carson, Peter E ^e   Belkin, Robert N ^f   Miller, Alan B ^g   Neuberg, Gerald W ^a   Frid, David ^b   Wertheimer, John H ^h   Cropp, Anne B ⁱ   Demets, David L ^j  

^a The New York Presbyterian Hospital   (United States)

^b DUKE UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f NEW YORK MEDICAL COLLEGE   (United States)

^g UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^h ALBERT EINSTEIN MEDICAL CENTER   (United States)

ⁱ PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^j UNIVERSITY OF WISCONSIN MADISON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EDEMA; FEMALE; GASTROINTESTINAL TOXICITY; HEART DILATATION; HEART FAILURE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE;

AGED; AMLODIPINE; CALCIUM CHANNEL BLOCKERS; CARDIOMYOPATHY, DILATED; CHRONIC DISEASE; DOUBLE-BLIND METHOD; FEMALE; HEART FAILURE, CONGESTIVE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0007410805     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199610103351504     Document Type: Article

References (30)

1. Elkayam U, Amin J, Mehra A, Vasquez J, Weber L, Rahimtoola SH. A prospective, randomized, double-blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. Circulation 1990;82:1954-61.
2. Barjon JN, Rouleau J-L, Bichet D, Juneau C, De Champlain J. Chronic renal and neurohumoral effects of the calcium entry blocker nisoldipine in patients with congestive heart failure. J Am Coll Cardiol 1987; 9:622-30.
3. Goldstein RE, Boccuzzi SJ, Cruess D, Nattel S, Adverse Experience Committee, Multiccnter Diltiazem Postinferction Research Group. Diltia zem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. Circulation 1991;83:52-60.
4. The Multicenter Diltiazem Postinfarction Trial Research Group. The effect of diltiazem on mortality and reinfarction after myocardial infarction. N Engl J Med 1988;319:385-92.
5. Tan LB, Murray RG, Littler WA. Felodipine in patients with chronic heart failure: discrepant haemodynamic and clinical effects. Br Heart J 1987;58:122-8.
6. Littler WA, Sheridan DJ. Placebo controlled trial of felodipine in patients with mild to moderate heart failure: UK Study Group. Br Heart J 1995;73:428-33.
7. Packer M, Kessler PD, Lee WH. Calcium-channel blockade in the management of severe chronic congestive heart failure: a bridge too far. Circulation 1987;75:Suppl V:V56-V64.
8. Packer M, Nicod P, Khandheria BR, et al. Randomized, multicenter, double-blind, placebo-controlled evaluation of amlodipine in patients with mild-to-moderate heart failure. J Am Coll Cardiol 1991;17:Suppl A:274A. abstract.
9. Smith WB, DeAbate AC, Gollub SB, et al. Beneficial long term hemodynamic and clinical effects of amlodipine in chronic heart failure: results of a multicenter randomized, double-blind, placebo-controlled, dose-ranging study. Circulation 1994;90:Suppl;I-603. abstract.
10. Packer M, Lee WH, Medina N, Yushak M, Bernstein JL, Kessler PD. Prognostic importance of the immediate hemodynamic response to nifedipine in patients with severe left ventricular dysfunction. J Am Coll Cardiol 1987;10:1303-11.
11. Lan KKG, DeMets DL. Discrete sequential boundaries of clinical trials. Biometrika 1983;70:659-63.
12. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979;35:549-56.
13. Kaplan EL, Meier P Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958:53:457-81.
14. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972;34: 187-202.
15. Packer M, Rouleau J-L, Swedberg K, et al. Effect of flosequinan on survival in chronic heart failure: preliminary results of the PROFILE Study. Circulation 1993;88:Suppl:I-301. abstract.
16. Packer M, Kukin ML. Management of patients with heart failure and angina: do coexistent diseases alter the response to cardiovascular drugs? J Am Coll Cardiol 1991;17:740-2.
17. Witchitz S, Haiat R, Tarrade T, Chiche P. Accidents cardio-vasculaires au cours des traitements par le vérapamil: a propos de 6 observations. Nouv Press Med 1975;4:337-8.
18. Elkayam U, Weber L, McKay C, Rahimtoola S. Spectrum of acute hemodynamic effects of nifedipine in severe congestive heart failure. Am J Cardiol 1985;56:560-6.
19. Packer M, Lee WH, Medina N, Yushak M. Comparative negative inotropic effects of nifedipine and diltiazem in patients with severe left ventricular dysfunction. Circulation 1985;72:Suppl III:III-275. abstract.
20. Ferlinz J, Gallo CT. Responses of patients in heart failure to long-term oral verapamil administration. Circulation 1984;70:Suppl II:II-305. abstract.
21. Packer M. Pathophysiological mechanisms underlying the adverse effects of calcium channel-blocking drugs in patients with chronic heart failure. Circulation 1989;80:Suppl IV:IV-59-IV-67.
22. Gheorghiade M, Hall V, Goldberg AD, Levine TB, Goldstein S. Long term clinical and neurohormonal effects of nicardipinc in patients with severe heart failure on maintenance therapy with angiotensin converting enzyme inhibitors. J Am Coll Cardiol 1991;17:Suppl A:274A. abstract.
23. Mohindra SK, Udeani GO. Long-acting verapamil and heart failure. JAMA 1989;261:994.
24. Singh SN, Fletcher RD, Fisher SG, et al. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. N Engl J Med 1995;333:77-82.
25. CIBIS Investigators and Committees. A randomized trial of β-blockade in heart failure: the Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation 1994;90:1765-73.
26. Gillmer DJ, Kark P. Pulmonary oedema precipitated by nifedipine. BMJ 1980;280:1420-1.
27. Batra AK, Segall PH, Ahmed T. Pulmonary edema with nifedipine in primary pulmonary hypertension. Respiration 1985;47:161-3.
28. Yoran C, Glassman E. The paradoxic effect of tolazoline hydrochloride on pulmonary hypertension of mitral stenosis. Chest 1973;63:843-6.
29. Semigran MJ, Cockrill BA, Kacmarek R, et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol 1994;24:982-8.
30. Haywood GA, Sneddon JF, Bashir Y, Jennison SH, Gray HH, McKenna WJ. Adenosine infusion for the reversal of pulmonary vasoconstriction in biventricular failure: a good test but a poor therapy. Circulation 1992;86:896-902.