Nitric oxide inhibits the secretion of T-helper 1- and T-helper 2-associated cytokines in activated human T cells

Immunology

Volumn 90, Issue 2, 1997, Pages 205-211

  Bauer, H ^a   Jung, T ^a   Tsikas, D ^b   Stichtenoth, D O ^b   Frolich J C ^b   Neumann, C ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LINSIDOMINE; MONOCLONAL ANTIBODY; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

ADULT; ARTICLE; CELL CLONE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031030722     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00161.x     Document Type: Article

References (29)

1. PALMER R.M., FERRIGE A.G. & MONCADA S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524.
2. GARTHWAITE J. (1991) Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 14, 60.
3. CHAN J., XING Y., MAGLIOZZO R.S. & BLOOM B.R. (1992) Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 175, 1111.
4. CUI S., REICHNER J.S., MATEO R.B. & ALBINA J.E. (1994) Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res 54, 2462.
5. NATHAN C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J 6, 3051.
6. MACNAUL K.L. & HUTCHINSON N.I. (1993) Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions. Biochem Biophys Res Commun 196, 1330.
7. ZEMBALA M., SIEDLAR M., MARCINKIEWICZ J. & PRYJMA J. (1994) Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide. Eur J Immunol 24, 435.
8. REILING N., ULMER A.J., DUCHROW M., ERNST M., FLAD H.D. & HAUSCHILDT S. (1994) Nitric oxide synthase: mRNA expression of different isoforms in human monocytes/macrophages. Eur J Immunol 24, 1941.
9. YAN L., VANDIVIER R.W., SUFFREDINI A.F. & DANNER R.L. (1994) Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity. J Immunol 153, 1825.
10. 2+ calmodulin-dependent isoform in human B and T lymphocytes. Eur J Immunol 26, 511.
11. TAYLOR ROBINSON A.W., LIEW F.Y., SEVERN A. et al. (1994) Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol 24, 980.
12. WEI X.Q., CHARLES I.G., SMITH A. et al. (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375, 408.
13. ROMAGNANI S. (1994) Lymphokine production by human T cells in disease states. Annu Rev Immunol 12, 227.
14. JUNG T., SCHAUER U., HEUSSER C, NEUMANN C. & RIEGER C. (1993) Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159, 197.
15. SAGER N., FELDMANN A., SCHILLING G., KREITSCH P. & NEUMANN C. (1992) House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 89, 801.
16. GUTGESELL C., YSSEL H., SCHEEL D., GERDES J. & NEUMANN C. (1994) IL-10 secretion of allergen-specific skin-derived T cells correlates positively with that of the Th2 cytokines IL-4 and IL-5. Exp Dermatol 3, 304.
17. JUNG T., SCHAUER U., RIEGER C. et al. (1995) Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells. Eur J Immunol 25, 2413.
18. TSIKAS D., BOGER R.H., BODE-BOGER S.M., GUTZKI F.M. & FROLICH J.C. (1994) Quantification of nitrite and nitrate in human urine and plasma as pentafluorobenzyl derivatives by gas chromatography-mass spectrometry using their 15N-labelled analogs. J Chromatogr B Biomed Appl 661, 185.
19. CHOMCZYNSKI P. & SACCHI N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156.
20. DING A.H., NATHAN C.F. & STUEHR D.J. (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141, 2407.
21. NUSSLER A.K., DI SILVIO M., BILLIAR T.R. et al. (1992) Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. (4).
22. FEELISCH M. (1991) The biochemical pathways of nitric oxide formation from nitrovasodilators: appropriate choice of exogenous NO donors and aspects of preparations and handling of aqueous NO solutions. J Cardiovasc Pharmacol 17, S25.
23. BARNES P.J. & LIEW F.Y. (1995) Nitric oxide and asthmatic inflammation. Immunol Today 16, 128.
24. MARCINKIEWICZ J. & CHAIN B.M. (1993) Differential regulation of cytokine production by nitric oxide. Immunology 80, 146.
25. KWON N.S., STUEHR D.J. & NATHAN C.F. (1996) Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med 174, 761.
26. GEIGER J., NOLTE C. & WALTER U. (1994) Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors. Am J Physiol 267, C236.
27. GAJEWSKI T.F., SCHELL S.R. & FITCH F.W. (1990) Evidence implicating utilization of different T cell receptor-associated signalling pathways by Th1 and Th2 clones. J Immunol 144, 4110.
28. LOS M., DROGE W., STRICKER K., BAEUERLE P.A. & SCHULZE OSTHOFF K. (1995) Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur J Immunol 25, 159.
29. NAKAZAWA M. & IMAI S. (1994) Rp-8-Br-guanosine-3′,5′-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta. Eur J Pharmacol 253, 179.