Effect of polymethylene and phenylene linking groups on the DNA cleavage specificity of distamycin-linked hydroxamic acid-vanadyl complexes

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 5, 2000, Pages 603-609

  Hashimoto, Shigeki ^a   Inui, Takahiro ^a   Nakamura, Yushin ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Distamycin; DNA cleavage; Hydroxamic acid; Pyrrolepeptide; Sequence specific cleavage; Vanadyl ion

Indexed keywords

4 [[[4 [[[4 [[2 (HYDROXYAMINOCARBONYL)PHENYLENECARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[3 (HYDROXYAMINOCARBONYL)PHENYLENECARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[4 (HYDROXYAMINOCARBONYL)BUTYRYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[4 (HYDROXYAMINOCARBONYL)PHENYLENECARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[5 (HYDROXYAMINOCARBONYL)VALERYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[6 (HYDROXYAMINOCARBONYL)HEXANOYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; 4 [[[4 [[[4 [[7 (HYDROXYAMINOCARBONYL)HEPTANOYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL 2 PYRROLYL]CARBONYL]AMINO] 1 METHYL N [3 (N,N DIMETHYLAMINO)PROPYL] 2 PYRROLECARBOXAMIDE; ANTINEOPLASTIC AGENT; DISTAMYCIN A DERIVATIVE; DNA; HYDROXAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VANADYL DERIVATIVE;

ARTICLE; DNA BASE COMPOSITION; DNA CLEAVAGE; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR RECOGNITION; STRUCTURE ACTIVITY RELATION;

EID: 0034037383     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.603     Document Type: Article

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