메뉴 건너뛰기




Volumn 46, Issue 1, 2000, Pages 71-80

Prognostic value of the expression of tumor suppressor genes p53, p21, p16 and pRb, and Ki-67 labelling in high grade astrocytomas treated with radiotherapy

Author keywords

Astrocytoma; Immunohistochemistry; p16; p21; p53; pRb

Indexed keywords

KI 67 ANTIGEN; PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 0034036394     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006473320474     Document Type: Article
Times cited : (54)

References (34)
  • 1
    • 0030271752 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors in 106 patients with malignant glioma
    • Salminen E, Nuutinen J, Huhtala S: Multivariate analysis of prognostic factors in 106 patients with malignant glioma. Eur J Cancer 32: 1918-1923, 1996
    • (1996) Eur J Cancer , vol.32 , pp. 1918-1923
    • Salminen, E.1    Nuutinen, J.2    Huhtala, S.3
  • 2
    • 0025738929 scopus 로고
    • A medical research council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma
    • The Medical Research Council Brain Tumour Working Party
    • Bleehen N, Stenning S: A medical research council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party. Br J Cancer 64: 769-774, 1991
    • (1991) Br J Cancer , vol.64 , pp. 769-774
    • Bleehen, N.1    Stenning, S.2
  • 4
    • 0029992897 scopus 로고    scopus 로고
    • Molecular genetics and molecular biology advances in brain tumors
    • James C, Olson J: Molecular genetics and molecular biology advances in brain tumors. Curr Opinion Onc 8: 188-195, 1996
    • (1996) Curr Opinion Onc , vol.8 , pp. 188-195
    • James, C.1    Olson, J.2
  • 5
    • 0028725419 scopus 로고
    • Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples
    • Sallinen P, Haapasalo H, Visakorpi T, Helen PT, Rantala IS, Isola JJ, Helin HJ: Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples. J Pathol 174: 275-282, 1994
    • (1994) J Pathol , vol.174 , pp. 275-282
    • Sallinen, P.1    Haapasalo, H.2    Visakorpi, T.3    Helen, P.T.4    Rantala, I.S.5    Isola, J.J.6    Helin, H.J.7
  • 6
    • 0025810796 scopus 로고
    • Immunobiochemical and molecular biologic characterization of the cell proliferation associated nuclear antigen that is defined by monoclonal antibody Ki-67
    • Gerdes J, Li L, Schlueter C, Duchrow MC, Wohlenberg C, Gerlach C: Immunobiochemical and molecular biologic characterization of the cell proliferation associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 138: 867-873, 1991
    • (1991) Am J Pathol , vol.138 , pp. 867-873
    • Gerdes, J.1    Li, L.2    Schlueter, C.3    Duchrow, M.C.4    Wohlenberg, C.5    Gerlach, C.6
  • 7
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin-embedded sections
    • Cattoretti G, Becker MHG, Key G, Duchrow M, Schluter C, Galle J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin-embedded sections. J Pathol 168: 357-363, 1992
    • (1992) J Pathol , vol.168 , pp. 357-363
    • Cattoretti, G.1    Becker, M.H.G.2    Key, G.3    Duchrow, M.4    Schluter, C.5    Galle, J.6    Gerdes, J.7
  • 8
    • 0022516999 scopus 로고
    • The use of monoclonal antibody Ki-67 in the identification of proliferating cells
    • Burger PC, Shibata T, Kleihues P: The use of monoclonal antibody Ki-67 in the identification of proliferating cells. Surg Pathol 10: 611-617, 1986
    • (1986) Surg Pathol , vol.10 , pp. 611-617
    • Burger, P.C.1    Shibata, T.2    Kleihues, P.3
  • 9
    • 0028865984 scopus 로고
    • Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK 4A in archival human solid tumors, correlation with retinoblastoma protein expression
    • Geradts J, Kratzke R, Niehans G, Wohlenberg C, Gerlach C: Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK 4A in archival human solid tumors, correlation with retinoblastoma protein expression. Cancer Res 55: 6006-6011, 1995
    • (1995) Cancer Res , vol.55 , pp. 6006-6011
    • Geradts, J.1    Kratzke, R.2    Niehans, G.3    Wohlenberg, C.4    Gerlach, C.5
  • 10
    • 0030910239 scopus 로고    scopus 로고
    • A molecular genetic model of astrocytoma histopathology
    • Louis D: A molecular genetic model of astrocytoma histopathology. Brain Pathol 7: 755-764, 1997
    • (1997) Brain Pathol , vol.7 , pp. 755-764
    • Louis, D.1
  • 12
    • 0028970955 scopus 로고
    • Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines
    • He J, Olson J, James C: Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 55: 4833-4836, 1995
    • (1995) Cancer Res , vol.55 , pp. 4833-4836
    • He, J.1    Olson, J.2    James, C.3
  • 14
    • 0030056824 scopus 로고    scopus 로고
    • Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas
    • Tsuzuki T, Tsunoda S, Sakaki T, Konishi N, Hiasa Y, Nakamura M: Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas. Cancer 78: 287-293, 1996
    • (1996) Cancer , vol.78 , pp. 287-293
    • Tsuzuki, T.1    Tsunoda, S.2    Sakaki, T.3    Konishi, N.4    Hiasa, Y.5    Nakamura, M.6
  • 16
    • 0028123442 scopus 로고
    • The p53 gene and protein in human brain tumors
    • Louis D: The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53: 11-21, 1994
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 11-21
    • Louis, D.1
  • 18
    • 0023839245 scopus 로고
    • Identification of proliferating cells in human gliomas using the monoclonal antibody Ki-67
    • Zuber P, Hamou MF, de Tribolet N: Identification of proliferating cells in human gliomas using the monoclonal antibody Ki-67. Neurosurgery 22: 364-368, 1988
    • (1988) Neurosurgery , vol.22 , pp. 364-368
    • Zuber, P.1    Hamou, M.F.2    De Tribolet, N.3
  • 19
    • 0027742856 scopus 로고
    • Aberrant p53 expression in astrocytic neoplasms of the brain, association with proliferation
    • Haapasalo H, Isola J, Sallinen P, Kalimo H, Helin H, Rantala I: Aberrant p53 expression in astrocytic neoplasms of the brain, association with proliferation. Am J Pathol 142: 1347-1351, 1993
    • (1993) Am J Pathol , vol.142 , pp. 1347-1351
    • Haapasalo, H.1    Isola, J.2    Sallinen, P.3    Kalimo, H.4    Helin, H.5    Rantala, I.6
  • 20
    • 0030064838 scopus 로고    scopus 로고
    • Prognostic significance of Ki-67 labelling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas
    • Wakimoto H, Aoyagi M, Nakayama T, Nagashima G, Yamamoto S, Tamaki M, Hirakawa K: Prognostic significance of Ki-67 labelling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas. Cancer 77: 373-380, 1996
    • (1996) Cancer , vol.77 , pp. 373-380
    • Wakimoto, H.1    Aoyagi, M.2    Nakayama, T.3    Nagashima, G.4    Yamamoto, S.5    Tamaki, M.6    Hirakawa, K.7
  • 21
    • 0030756094 scopus 로고    scopus 로고
    • Use of MIB-1 (Ki-67) immunoreactivity in differentiating grade II and grade III gliomas
    • Hsu D, Louis D, Efird J, Hedley-Whyte E: Use of MIB-1 (Ki-67) immunoreactivity in differentiating grade II and grade III gliomas. J Neuropathol Exp Neurol 56: 857-865, 1997
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 857-865
    • Hsu, D.1    Louis, D.2    Efird, J.3    Hedley-Whyte, E.4
  • 22
    • 0029397307 scopus 로고
    • The p53 gene and its role in human brain tumors
    • Bögler O, Huang HJ, Kleihues P, Cavenee WK: The p53 gene and its role in human brain tumors. Glia 15: 308-327, 1995
    • (1995) Glia , vol.15 , pp. 308-327
    • Bögler, O.1    Huang, H.J.2    Kleihues, P.3    Cavenee, W.K.4
  • 24
    • 0028087884 scopus 로고
    • Pathways leading to glioblastoma multiforme, a molecular analysis of genetic alterations in 65 astrocytic tumors
    • Lang F, Miller D, Koslow M, Newcomb E: Pathways leading to glioblastoma multiforme, a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 81: 427-436, 1994
    • (1994) J Neurosurg , vol.81 , pp. 427-436
    • Lang, F.1    Miller, D.2    Koslow, M.3    Newcomb, E.4
  • 26
    • 0000180377 scopus 로고    scopus 로고
    • Genetics of glioma progression and the definition of primary and secondary glioblastoma
    • Kleihues P, Ohgaki H: Genetics of glioma progression and the definition of primary and secondary glioblastoma. Brain Pathol 7: 1131-1136, 1997
    • (1997) Brain Pathol , vol.7 , pp. 1131-1136
    • Kleihues, P.1    Ohgaki, H.2
  • 27
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually excusive in the evolution of primary and secondary glioblastomas
    • Watanabe K, Tachibana O, Sato K, Yonekawa Y, Kleihues P, Ohgaki H: Overexpression of the EGF receptor and p53 mutations are mutually excusive in the evolution of primary and secondary glioblastomas. Brain Pathol 6: 217-224, 1996
    • (1996) Brain Pathol , vol.6 , pp. 217-224
    • Watanabe, K.1    Tachibana, O.2    Sato, K.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 29
    • 0027313366 scopus 로고
    • A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme
    • Newcomb EW, Madonia WJ, Pisharody S, Lang FF, Koslow M, Miller DC: A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme. Brain Pathol 3: 229-235, 1993
    • (1993) Brain Pathol , vol.3 , pp. 229-235
    • Newcomb, E.W.1    Madonia, W.J.2    Pisharody, S.3    Lang, F.F.4    Koslow, M.5    Miller, D.C.6
  • 31
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson J, Efird J, von Deimling A, Louis D: CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56: 150-153, 1996
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.3    Efird, J.4    Von Deimling, A.5    Louis, D.6
  • 34
    • 0030909375 scopus 로고    scopus 로고
    • Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4A genes in astrocytomas
    • Rao LS, Miller DC, Newcomb EW: Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4A genes in astrocytomas. Diagn Mol Pathol 6: 115-122, 1997
    • (1997) Diagn Mol Pathol , vol.6 , pp. 115-122
    • Rao, L.S.1    Miller, D.C.2    Newcomb, E.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.