Synthesis and evaluation of poly(ethylene glycol)-polylysine block copolymers as carriers for gene delivery

Journal of Bioactive and Compatible Polymers

Volumn 15, Issue 2, 2000, Pages 115-138

  Vanderkerken, S ^a   Vanheede, T ^a   Toncheva, V ^a   Schacht, E ^a   Wolfert, M A ^b   Seymour, L ^b   Urtti, A ^c  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CHLORINE COMPOUNDS; CONTROLLED DRUG DELIVERY; DNA; GENES; PARTICLES (PARTICULATE MATTER); POLYELECTROLYTES; POLYETHYLENE GLYCOLS; SYNTHESIS (CHEMICAL); TOXICITY;

CHLOROQUINE; ETHIDIUM BROMIDE FLUORESCENCE TECHNIQUE; RED BLOOD CELLS; TRANSFECTION EFFICIENCY;

BLOCK COPOLYMERS;

CHLOROQUINE; COPOLYMER; MACROGOL; POLYLYSINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG DNA BINDING; DRUG SYNTHESIS; GENE TARGETING; GENE THERAPY; HEMAGGLUTINATION; HEMOLYSIS; HUMAN; HUMAN CELL; NONHUMAN; PARTICLE SIZE;

EID: 0034035326     PISSN: 08839115     EISSN: None     Source Type: Journal    
DOI: 10.1106/MVEK-KHWR-QUDG-CTYA     Document Type: Article

References (28)

1. S.L. Eck, J.M. Wilson, Goodman & Gilman's. 1996. The Pharmaceutical Basis of Therapeutics 9/e Chapter 5 Gene-Based Therapy. ed. Mc Graw-Hill.
2. S.I. Michael, D.T. Curiel. Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway. 1994. Gene Therapy, 1:223-232.
3. T. Friedmann. Progress Toward Human Gene Therapy. 1989. Science 244:1275-1281.
4. P.L. Felgner. Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. 1990. Advanced Drug Delivery Reviews, 5:163-187.
5. J.P. Behr. Synthetic Gene-Transfer Vectors. 1993. Acc. Chem. Res., 26:274-278.
6. A.V. Kabanov, S.V. Vinogradov, Y.G. Suzdaltseva, V.Y. Alakhov. Water-soluble block polycations as carriers for oligonucleotide delivery. 1995. Bioconjugate Chemistry, 6:639-643.
7. E. Tomlinson, A.P. Rolland. Controllable gene therapy. Pharmaceutics of non-viral gene delivery systems. 1996. Journal of Controlled Release, 39:357-372.
8. R.M. Straubinger, D. Papahadjopoulos. Liposomes as carriers for intracellular delivery of nucleic acids. 1983. Methods in Enzymology, 101:512-527.
9. G.Y. Wu, C.H. Wu. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. 1987. J. Biol. Chem., 262:4429-4432.
10. E. Wagner, M. Cotten, R. Foisner, M.L. Birnstiel. Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells. 1991. Proc. Natl. Acad. Sci., 88:4255-4259.
11. O. Boussif, F. Lezoualc'H, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, J.P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine.1995. Proc. Natl. Acad. Sci. USA, 92:7297-7301.
12. M.A. Wolfert, E. Schacht, V. Toncheva, K. Ulbrich, O. Nazarova, L.W. Seymour. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. 1996. Human Gene Therapy, 7:2123-2133.
13. P.R. Dash, V. Toncheva, E. Schacht, L.W. Seymour. Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro. 1997. Journal of Controlled Release, 48:269-276.
14. V. Toncheva, M.A. Wolfert, P.R. Dash, D. Oupicky, K. Ulbrich, L.W. Seymour, E.H. Schacht. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. 1998. Biochemica et Biophysica Acta, 1380:354-368.
15. S. Vanderkerken, V. Toncheva, T. Vanheede, L. Seymour, M. Wolfert, E. Schacht. Synthesis and evaluation of poly(ethylene oxide)-polyamine block co-polymers. 1998. 3rd International Symposium on Polymer Therapeutics at the University of London, January 7th-9th:p. 65.
16. K. Kataoka, H. Togawa, A. Harada, K. Yasugi, T. Matsumoto, S. Katayose. Spontaneous formation of poly-ion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline. 1996. Macromolecules, 29:8556-8557.
17. S. Katayose, K. Kataoka. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer. 1997. Bioconj. Chem., 8:702-707.
18. S. Katayose, K. Kataoka. Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer. 1998. Journal of Pharmaceutical Sciences, 87:160-162.
19. F. Fuertges, A. Abuchowski. The clinical efficacy of poly(ethylene glycol)-modified proteins. 1990. Journal of Controlled Release, 11:139-148.
20. M.K. Pratten, J.B. Lloyd, G. Hörpel, H. Ringsdorf. Micelle-forming block copolymers-pinocytosis by macrophages and interaction with model membranes. 1985. Makromol. Chem., 186:725-733.
21. W.D. Fuller, M.S. Verlander, M. Goodman. A procedure for the facile synthesis of amino acid N-carboxyanhydrides. 1976. Biopolymers, 15:1869-1871.
22. H. Kricheldorf. 1987. α-Amino Acid-n-Carboxyanhydrides and Related Heterocycles. Springer-Verlag, Berlin, 88-92.
23. J. Loccufier, J. Crommen, J. Vandorpe, E. Schacht. End-group modification of α-hydroxy-ω-methoxy poly(oxyethylene) II. 1991. Makromol. Chem. Rapid Commun., 12:159-165.
24. M. Bodansky. 1984. The Practice of Peptide Synthesis. Springer-Verlag Berlin, 187.
25. A. Nevo, A. De Vries, A. Katchalsky. Interaction of basic polyamino acids with the red blood cell. I. Combination of polylysine with single cells. 1955. Biochemica et Biophysica Acta, 17:536-547.
26. M. Bhakoo, T.H. Birkbeck, J.H. Freer. Phospholipid-dependent changes in membrane permeability induced by staphylococcal δ-lysin and bee venom melittin. 1985. Can. J. Biochem. Cell Biol., 63:1-6.
27. A. Katchalsky, D. Danon, A. Nevo. Interaction of basic polyelectrolytes with the red blood cell. II. Agglutination of red blood cells by polymeric bases. 1959. Biochemica et Biophysica Acta, 33:120-138.
28. P. Erbacher, A.C. Roche, M. Monsigny, P. Midoux. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes. 1996. Experimental Cell Research, 225:186-194.