Systemic infections with Candida sp. and Aspergillus sp. in immunocompromised patients with hematological malignancies: Current serological and molecular diagnostic methods

Chemotherapy

Volumn 46, Issue 3, 2000, Pages 219-228

  Buchheidt, Dieter ^a   Skladny, Heyko ^a   Baust, Corinna ^a   Hehlmann, Rüdiger ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aspergillus sp.; Candida sp.; Hematology; Molecular methods; Polymerase chain reaction; Serological assays

Indexed keywords

BETA GLUCAN; ENOLASE; FUNGAL DNA; FUNGAL PROTEIN; FUNGUS ANTIBODY; GALACTOMANNAN; MANNAN;

ANTIBODY DETECTION; ASPERGILLOSIS; BLOOD DISEASE; BRONCHOSCOPY; CANDIDIASIS; CLINICAL TRIAL; DIAGNOSTIC ACCURACY; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNGUS CULTURE; GENE SEQUENCE; HIGH RISK POPULATION; HUMAN; IMMUNE DEFICIENCY; IMMUNOASSAY; LUNG LAVAGE; MOLECULAR BIOLOGY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVIEW; SERODIAGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING;

EID: 0034035040     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007283     Document Type: Review

References (82)

1. Bodey G, Bueltmann B, Duguid W, Gibbs D, Hanak H, Hotchi M, Mall G. Martino P, Meunier F, Milliken S: Fungal infections in cancer patients: An international autopsy survey. Eur J Clin Microbiol Infect Dis 1992;11:99.
2. Chandrasekar FH, Weinmann A, Shearer C: Autopsy-identified infections among hone marrow transplant recipients: A clinico-pathologic study of 56 patients. Bone Marrow Transplant 1995;16:675.
3. Denning DW: Treatment of invasive aspergillosis. J Infect 1994;28: 25.
4. Denning DW: Diagnosis and management of invasive aspergillosis. Curr Clin Top Infect Dis 1996;16: 277.
5. Denning DW, Mannus A, Cohen J, Spence D, Herbrecht R, Pagano L, Kibbler C, Kermery V, Offner F, Cordonnier C, Jehn U, Ellis M, Collette L, Sylvester R: An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: Diagnosis and therapeutic outcome. EORTC Invasive Fungal Infections Cooperative Group. J Infect 1998;37:173.
6. Denning DW: Invasive aspergillosis. Clin Infect Dis 1998;26:781.
7. Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K: Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J Infect 1996;33:23.
8. Horn R, Wong B, Kiehn TE, Armstrong D: Fungemia in a cancer hospital: Changing frequency, earlier onset, and results of therapy. Rev Infect Dis 1985;7:646.
9. Pfaffenbach B, Donhuijsen K, Pahnke J, Bug R, Adamek RJ, Wegener M, Ricken D: Systemic fungal infections in hematologic neoplasms. An autopsy study of 1,053 patients. Med Klin 1994;89:299.
10. Saugier-Veber P, Devergie A, Sulahian A, Ribaud P, Traore F, Bourdeau-Esperou H, Gluckman E, Derouin F: Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: Results of a 5-year retrospective study. Bone Marrow Transplant 1993;12:121.
11. Denning DW, Evans EG, Kibbler CC, Richardson MD, Roberts MM, Rogers TR, Warnock DW, Warren RE: Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. British Society for Medical Mycology. Eur J Clin Microbiol Infect Dis 1997;16: 424.
12. Chanock SJ, Pizzo PA: Infectious complications of patients undergoing therapy for acute leukemia: Current status and future prospects. Semin Oncol 1997;24:132.
13. Guiot HF, Fibbe WE, van 't Wout JW: Risk factors for fungal infection in patients with malignant hematologic disorders: Implications for empirical therapy and prophylaxis. Clin Infect Dis 1994;18:525.
14. Komshian SV, Uwaydah AK, Sobel JD, Crane LR: Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: Frequency, characteristics, and evaluation of factors influencing outcome. Rev Infect Dis 1989;11: 379.
15. Morrison VA, Haake RJ, Weisdorf DJ: The spectrum of non-Candida fungal infections following bone marrow transplantation. Medicine (Baltimore) 1993;72:78.
16. Morrison VA, Haake RJ, Weisdorf DJ: Non-Candida fungal infections after bone marrow transplantation: Risk factors and outcome. Am J Med 1994;96:497.
17. Blum U, Windfuhr M, Buitrage-Tellez C, Sigmand G, Herbst EW, Langer M: Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest 1994; 106:1156.
18. Caillot D, Casasnovas O, Bernard A, Couaillier JF, Durand C, Cuisenier B, Solary E, Piard F, Petrella T, Bonnin A, Couillault G, Dumas M, Guy H: Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J Clin Oncol 1997;15:139.
19. von Eiff, Zuhlsdorf M, Roos N, Hesse M, Schulten R, van de Loo J: Pulmonary fungal infections in patients with hematological malignancies - Diagnostic approaches. Ann Hematol 1995;70:135.
20. Rinaldi MG: Problems in the diagnosis of invasive fungal diseases. Rev Infect Dis 1991;13:493.
21. Logan PM, Primack SL, Miller RR, Muller NL: Invasive aspergillosis of the airways: Radiographic, CT, and pathologic findings. Radiology 1994;193:383.
22. Logan PM, Muller NL: CT manifestations of pulmonary aspergillosis. Crit Rev Diagn Imaging 1996;37:1.
23. Logan PM, Muller NL: High-resolution computed tomography and pathologic findings in pulmonary aspergillosis: A pictorial essay. Can Assoc Radiol J 1996;47:444.
24. Walsh TJ, Garrett K, Feurerstein E, Girton M, Allende M, Bacher J, Francesconi A, Schaufele R, Pizzo PA: Therapeutic monitoring of experimental invasive pulmonary aspergillosis by ultrafast computerized tomography, a novel, noninvasive method for measuring responses to antifungal therapy. Antimicrob Agents Chemother 1995;39:1065.
25. Cho SY, Choi HY: Opportunistic fungal infection among cancer patients. A ten-year autopsy study. Am J Clin Pathol 1979;72:617.
26. Duthie R, Denning DW: Aspergillus fungemia: Report of two cases and review. Clin Infect Dis 1995;20: 598.
27. Walsh TJ, Lee J, Lecciones J, Rubin M, Butler K, Francis P, Weinberger M, Roilides E, Marshall D, Gress J: Empiric therapy with amphotericin B in febrile granulocytopenic patients. Rev Infect Dis 1991;13:496.
28. Kappe R, Schulze-Berge A, Sonntag HG: Evaluation of eight antibody tests and one antigen test for the diagnosis of invasive aspergillosis. Mycoses 1996;39:13.
29. Patterson TF, Miniter P, Patterson JE, Rappsport JM, Andriole VT: Aspergillus antigen detection in the diagnosis of invasive aspergillosis. J Infect Dis 1995;171:1553.
30. Martino P, Girmenia C, Micozzi A, Raccah R, Gentile G, Venditti M, Mandelli F: Fungemia in patients with leukemia. Am J Med Sci 1993; 306:225.
31. Gentry LO, Wilkinson ID, Lea AS, Price MF: Latex agglutination test for detection of Candida antigen in patients with disseminated disease. Eur J Clin Microbiol 1983;2:122.
32. Gutierrez J, Maroto C, Piedrola G, Martin E, Perez JA: Circulating Candida antigens and antibodies: Useful markers of candidemia. J Clin Microbiol 1993;31:2550.
33. Obayashi T, Yoshida M, Mori T, Goto H, Yasuoka A, Iwasaki H, Teshima H, Kohno S, Horiuchi A, Ito A: Plasma (1→3)beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet 1995;345:17.
34. Walsh TJ, Lee JW, Sien T, Schaufele R, Bacher J, Switchenko AC, Goodman TC, Pizzo PA: Serum D-arabinitol measured by automated quantitative enzymatic assay for detection and therapeutic monitoring of experimental disseminated candidiasis: Correlation with tissue concentrations of Candida albicans. J Med Vet Mycol 1994;32:205.
35. Walsh TJ, Merz WG, Lee JW, Schaufele R, Sein T, Whitcomb PO, Ruddel M, Burns W, Wingard JR, Switchenko AC: Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum D-arabinitol. Am J Med 1995;99:164.
36. Matthews RC, Burnie JP, Tabaqchali S: Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans. J Clin Microbiol 1987;25:230.
37. Walsh TJ, Hathorn JW, Sobel JD, Merz WG, Sanchez V, Maret SM, Buckley HR, Pfaller MA, Schaufele R, Silva C: Detection of circulating Candida enolase by immunoassay in patients with cancer and invasive candidiasis. N Engl J Med 1991; 324:1026.
38. Mitsutake K, Miyazaki T, Tashiro T, Yamamoto Y, Kakeya H, Otsubo T, Kawamura S, Hossain MA, Noda T, Hirakata Y, Kohno S: Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia. J Clin Microbiol 1996;34:1918.
39. Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N: Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis 1988;158:1185.
40. Huppertz HI, Schmidt H, Karch H: Detection of Borrelia burgdorferi by nested polymerase chain reaction in cerebrospinal fluid and urine of children with neuroborreliosis. Eur J Pediatr 1993;152:414.
41. Burg JL, Grover CM, Pouletty P, Boothroyd JC: Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol 1989;27:1787.
42. Makimura K, Murayama SY, Yamaguchi H: Specific detection of Aspergillus and Penicillium species from respiratory specimens by polymerase chain reaction (PCR). Jpn J Med Sci Biol 1994;47:141.
43. Makimura K, Murayama SY, Yamaguchi H: Detection of a wide range of medically important fungi by the polymerase chain reaction. J Med Microbiol 1994;40:358.
44. Melchers WJ, Verweij PE, van den Hurk P, van Belkum A, de Pauw BE, Hoogkamp-Korstanje JA, Meis JF: General primer-mediated PCR for detection of Aspergillus species. J Clin Microbiol 1994;32:1710.
45. Spreadbury C, Holden D, Aufauvre-Brown A, Bainbridge B, Cohen J: Detection of Aspergillus fumigatus by polymerase chain reaction. J Clin Microbiol 1993;31:615.
46. Tang CM, Holden DW, Aufauvre-Brown A, Cohen J: The detection of Aspergillus spp. by the polymerase chain reaction and its evaluation in bronchoalveolar lavage fluid. Am Rev Respir Dis 1993;148:1313.
47. Aufauvre-Brown A, Cohen J, Holden DW: Use of randomly amplified polymorphic DNA markers to distinguish isolates of Aspergillus fumigatus. J Clin Microbiol 1992;30: 2991.
48. Birch M, Nolard N, Shankland GS, Denning DW: DNA typing of epidemiologically-related isolates of Aspergillus fumigatus. Epidemiol Infect 1995;114:161.
49. Radford SA, Johnson EM, Leeming JP, Millar MR, Cornish JM, Foot AB, Warnock DW: Molecular epidemiological study of Aspergillus fumigatus in a bone marrow transplantation unit by PCR amplification of ribosomal intergenic spacer sequences. J Clin Microbiol 1998;36: 1294.
50. Haynes KA, Westerneng TJ: Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species-specific PCR of large subunit ribosomal DNA. J Med Microbiol 1996;44:390.
51. Walsh TJ, Francesconi A, Kasai M, Chanock SJ: PCR and single-strand conformational polymorphism for recognition of medically important opportunistic fungi. J Clin Microbiol 1995;33:3216.
52. Einsele H, Hebart H, Roller G, Loffler J, Rothenhofer I, Muller CA, Bowden RA, van Burik J, Engelhard D, Kanz L, Schumacher U: Detection and identification of fungal pathogens in blood by using molecular probes. J Clin Microbiol 1997; 35:1353.
53. Kappe R, Fauser C, Okeke CN, Maiwald M: Universal fungus-specific primer systems and group-specific hybridization oligonucleotides for 18S rDNA. Mycoses 1996;39: 25.
54. Kappe R, Okeke CN, Fauser C, Maiwald M, Sonntag HG: Molecular probes for the detection of pathogenic fungi in the presence of human tissue. J Med Microbiol 1998;47: 811.
55. Van Burik JA, Myerson D, Schreckhise RW, Bowden RA: Panfungal PCR assay for detection of fungal infection in human blood specimens. J Clin Microbiol 1998;36: 1169.
56. Robinson LA, Reed EC, Galbraith TA, Alonso A, Moulton AL, Fleming WH: Pulmonary resection for invasive Aspergillus infections in immunocompromised patients. J Thorac Cardiovasc Surg 1995;109: 1182.
57. Manso E, Montillo M, De Sio G, D'Amico S, Discepoli G, Leoni P: Value of antigen and antibody detection in the serological diagnosis of invasive aspergillosis in patients with hematological malignancies. Eur J Clin Microbiol Infect Dis 1994;13:756.
58. Hearn VM, Pinel C, Blachier S, Ambroise-Thomas P, Grillot R: Specific antibody detection in invasive aspergillosis by analytical isoelectrofocusing and immunoblotting methods. J Clin Microbiol 1995;33:982.
59. Andrews CP, Weiner MH: Aspergillus antigen detection in bronchoalveolar lavage fluid from patients with invasive aspergillosis and aspergillomas. Am J Med 1982;73: 372.
60. Rogers TR, Haynes KA, Barnes RA: Value of antigen detection in predicting invasive pulmonary aspergillosis. Lancet 1990;336:1210.
61. Sulahian A, Tabouret M, Ribaud P, Sarfati J, Gluckman E, Latge JP, Derouin F: Comparison of an enzyme immunoassay and latex agglutination test for detection of galactomannan in the diagnosis of invasive aspergillosis. Eur J Clin Microbiol Infect Dis 1996;15:139.
62. Rath PM, Oeffelke R, Muller KD, Ansorg R: Non-value of Aspergillus antigen detection in bronchoalveolar lavage fluids of patients undergoing bone marrow transplantation. Mycoses 1996;39:367.
63. Haynes K, Rogers TR: Retrospective evaluation of a latex agglutination test for diagnosis of invasive aspergillosis in immunocompromised patients. Eur J Clin Microbiol Infect Dis 1994;13:670.
64. Stynen D, Goris A, Sarfati J, Latge JP: A new sensitive sandwich enzyme-linked immunosorbent assay to detect galactofuran in patients with invasive aspergillosis. J Clin Microbiol 1995;33:497.
65. Verweij PE, Rijs AJ, de Pauw BE, Horrevorts AM, Hoogkamp-Korstanje JA, Meis JF: Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis. J Clin Pathol 1995;48:474.
66. Verweij PE, Latge JP, Rijs AJ, Melchers WJ, de Pauw BE, Hoogkamp-Korstanje JA, Meis JF: Comparison of antigen detection and PCR assay using bronchoalveolar lavage fluid for diagnosing invasive pulmonary aspergillosis in patients receiving treatment for hematological malignancies. J Clin Microbiol 1995;33:3150.
67. Swanink CM, Meis JF, Rijs AJ, Donnelly JP, Verweij PE: Specificity of a sandwich enzyme-linked immunosorbent assay for detecting Aspergillus galactomannan. J Clin Microbiol 1997;35:257.
68. Machetti M, Feasi M, Mordini N, Van Lint MT, Bacigalupo A, Latge JP, Sarfati J, Viscoli C: Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipients. Bone Marrow Transplant 1998;21: 917.
69. Siemann M, Koch-Dorfler M, Gaude M: False-positive results in premature infants with the Platelia Aspergillus sandwich enzyme-linked immunosorbent assay. Mycoses 1998;41:373.
70. Verweij PE, Erjavec Z, Sluiters W, Goessens W, Rozenberg-Arska M, Debets-Ossenkopp YJ, Guiot HF, Meis JF: Detection of antigen in sera of patients with invasive aspergillosis: Intra- and interlaboratory reproducibility. The Dutch Interuniversity Working Party for Invasive Mycoses. J Clin Microbiol 1998;36: 1612.
71. Paugam A, Sarfati J, Romieu R, Viguier M, Dopouy-Camet J, Latge JP: Detection of Aspergillus galactomannan: Comparison of an enzyme-linked immunoassay and a europium-linked time-resolved fluoro-immunoassay. J Clin Microbiol 1998;36:3079.
72. Reddy LV, Kumar A, Kurup VP: Specific amplification of Aspergillus fumigatus DNA by polymerase chain reaction. Mol Cell Probes 1993;7:121.
73. Bretagne S, Costa JM, Marmorat-Khuong A, Poron F, Cordonnier C, Vidaud M, Fleury-Feith J: Detection of Aspergillus species DNA in bronchoalveolar lavage samples by competitive PCR. J Clin Microbiol 1995;33:1164.
74. Yamakami Y, Hashimoto A, Tokimatsu I, Nasu M: PCR detection of DNA specific for Aspergillus species in serum of patients with invasive aspergillosis. J Clin Microbiol 1996; 34:2464.
75. Jones ME, Fox AJ, Barnes AJ, Oppenheim BA, Balagopal P, Morgenstern GR, Scarffe JH: PCR-ELISA for the early diagnosis of invasive pulmonary aspergillus infection in neutropenic patients. J Clin Pathol 1998;51:652.
76. Einsele H, Quabeck K, Muller KD, Hebart H, Rothenhofer I, Loffler J, Schaefer UW: Prediction of invasive pulmonary aspergillosis from colonisation of lower respiratory tract before marrow transplantation. Lancet 1998;352:1443.
77. Bretagne S, Costa JM, Bart-Delabesse E, Dhedin N, Rieux C, Cordonnier C: Comparison of serum galactomannan antigen detection and competitive polymerase chain reaction for diagnosing invasive aspergillosis. Clin Infect Dis 1998;26: 1407.
78. Bretagne S, Costa JM, Bart-Delabesse E, Dhedin N, Rieux C, Cordonnier C: Comparison of serum galactomannan antigen detection and competitive polymerase chain reaction for diagnosing invasive aspergillosis. Clin Infect Dis 1998;26: 1407.
79. Yamakami Y, Hashimoto A, Yamagata E, Kamberi P, Karashima R, Nagai H, Nasu M: Evaluation of PCR for detection of DNA specific for Aspergillus species in sera of patients with various forms of pulmonary aspergillosis. J Clin Microbiol 1998;36:3619.
80. Kawamura S, Maesaki S, Noda T, Hirakata Y, Tomono K, Tashiro T, Kohno S: Comparison between PCR and detection of antigen in sera for diagnosis of pulmonary aspergillosis. J Clin Microbiol 1999; 37:218.
81. Kami M, Shirouzu I, Mitani K, Ogawa S, Matsumura T, Kanda Y, Masumoto T, Saito T, Tanaka Y, Maki K, Honda H, Chiba S, Ohtomo K, Hirai H, Yazaki Y: Early diagnosis of central nervous system aspergillosis with combination use of cerebral diffusion-weighted echo-planar magnetic resonance image and polymerase chain reaction of cerebrospinal fluid. Intern Med 1999;38:45.
82. Skladny H, Buchheidt D, Baust C, Krieg-Schneider F, Seifarth W, Leib-Mösch C, Hehlmann R: Specific detection of Aspergillus species in blood and BAL samples of immunocompromised patients by two-step PCR. J Clin Microbiol 1999;37: 3865.