Synaptophysin gene expression in schizophrenia: Investigation of synaptic pathology in the cerebral cortex

British Journal of Psychiatry

Volumn 176, Issue MAR., 2000, Pages 236-242

  Eastwood, Sharon L ^b   Cairns, Nigel J ^b   Harrison, Paul J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SYNAPTOPHYSIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MENTAL DISEASE; NEUROPATHOLOGY; PREFRONTAL CORTEX; PSYCHOSIS; SCHIZOPHRENIA;

ADULT; AGED; AGED, 80 AND OVER; AUTORADIOGRAPHY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CEREBRAL CORTEX; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RNA, MESSENGER; SCHIZOPHRENIA; SYNAPTOPHYSIN;

EID: 0034034857     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.176.3.236     Document Type: Article

References (35)

1. Aganova, E. A. & Uranova, N. A. (1992) Morphometric analysis of synaptic contacts in the anterior limbic cortex in the endogenous psychoses. Neuroscience and Behavioural Physiology, 22, 59-65.
2. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington, DC: APA.
3. Browning, M. D., Dudek, E. M., Rapler, J. L., et al (1993) Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics. Biological Psychiatry, 34, 529-535.
4. 2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology, 15, 442-445.
5. Eastwood, S. L. & Harrison, P. J. (1995) Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Neuroscience, 69, 339-343.
6. _ & _ (1998) Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia. Neuroscience, 86, 437-448.
7. _ & _ (1999) Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections. Neuroscience, 93, 99-106.
8. _, Burnet, P. W. J., McDonald, B., et al (1994) Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study. Neuroscience, 59, 881-892.
9. _, _ & Harrison, P. J. (1995) Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience, 66, 309-319.
10. Gabriel, S. M., Haroutunian, V., Powchik, P., et al (1997) Increased concentrations of presynaptic proteins in the cingulate cortex of subjects with schizophrenia. Archives of General Psychiatry, 54, 559-566.
11. Glantz, L. A. & Lewis, D. A. (1997) Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia - regional and diagnostic specificity. Archives of General Psychiatry, 54, 943-952.
12. Harrison, P. J. (1999a) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain, 122, 593-624.
13. _ (1999b) The neuropathological effects of antipsychotic drugs. Schizophrenia Research, 40, 87-99.
14. _ & Eastwood, S. L. (1998) Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. Lancet, 352, 1669-1673.
15. _ , Heath, P. R., Eastwood, S. L., et al (1995) The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: Selective mRNA vulnerability and comparison with their encoded proteins. Neuroscience Letters, 200, 151-154.
16. _, Burnet, P. W. J., Falkai, P., et al (1997) Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex. Schizophrenia Research, 26, 93-102.
17. Heffernan, J. M., Eastwood, S. L., Nagy, Z., et al (1998) Temporal cortex synaptophysin mRNA is reduced in Alzheimers disease and is negatively correlated with the severity of dementia. Experimental Neurology, 150, 235-239.
18. Highley, J. R., Esiri, M. M., McDonald, B., et al (1998) Anomalies of cerebral asymmetry in schizophrenia interact with gender and age of onset: a post-mortem study. Schizophrenia Research, 34, 13-25
19. Honer, W. G., Falkai, P., Young, C., et al (1997) Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience, 78, 99-110.
20. _ , _ , Chen, C., et al (1999) Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience, 91, 1247-1255.
21. Karson, C. N., Mrak, R. E., Schluterman, K. O., et al (1999) Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for 'hypofrontality'. Molecular Psychiatry, 4, 39-45.
22. Keshavan, M. S., Anderson, S. & Pettegrew, J. W. (1994) Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex - the Feinberg hypothesis revisited. Journal of Psychiatric Research, 28, 239-265.
23. Lawrle, S. M. & Abukmeil, S. S. (1998) Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry, 172, 110-120.
24. Masliah, E. & Terry, R. D. (1993) The role of synaptic proteins in the pathogenesis of disorders of the central nervous system. Brain Pathology, 3, 77-85.
25. Perrone-Bizzozero, N. I., Sower, A. C., Bird, E. D., et al (1996) Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 93, 14182-14187.
26. Peters, A. & Jones, E. G. (1984) Cerebral Cortex. Vol. 1. Cellular Components of the Cerebral Cortex. New York: Plenum Press.
27. Rodriguez, R. M., Weickert, C. S., Herman, M. M., et al (1998) Synaptophysin mRNA in normal postnatal prefrontal cortex development and in schizophrenic versus normal control. Society for Neuroscience Abstracts, 24, 987.
28. Selemon, L. D. & Goldman-Rakic, P. S. (1999) The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry, 45, 17-25.
29. Tcherepanov, A. A. & Sokolov, B. P. (1997) Age-related abnormalities in expression of mRNAs encoding synapsin IA, synapsin IB, and Synaptophysin in the temporal cortex of schizophrenics. Journal of Neuroscience Research, 49, 639-644.
30. Thompson, P. M., Sower, A. C. & Perrone-Bizzozero, N. I. (1998) Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia. Biological Psychiatry, 43, 239-243.
31. Vawter, M. P., Howard, A. L., Hyde, T. M., et al (1999) Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia. Molecular Psychiatry, 4, 467-475.
32. Weinberger, D. R. & Berman, K. F. (1996) Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London: Series B, Biological Sciences, 351, 1495-1503.
33. Woo, T. U., Whitehead, R. E., Melchitzky, D. S., et al (1998) A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 95, 5341-5346.
34. World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Geneva: WHO.
35. Young, C. E., Arima, K., Xie, J., et al (1998) SNAP-25 deficit and hippocampal connectivity in schizophrenia. Cerebral Cortex, 8, 261-268.