A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro

Bone

Volumn 26, Issue 5, 2000, Pages 451-459

  Johansson, L ^a   Grubb, A ^b   Abrahamson, M ^b   Kasprzykowski, F ^c   Kasprzykowska, R ^c   Grzonka, Z ^c   Lerner, U H ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF GDA SK   (Poland)

Author keywords

Bone resorption; Cystatins; Cysteine proteinases; Osteoclasts

Indexed keywords

CALCITONIN; CYSTATIN C; CYSTATITIN C DERIVATIVE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BONE MATRIX; CALCIUM TRANSPORT; CALVARIA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME BINDING; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; OSTEOLYSIS;

ANIMALS; BONE AND BONES; BONE RESORPTION; CYSTATINS; DIAZOMETHANE; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; ORGAN CULTURE TECHNIQUES; PROTEIN BIOSYNTHESIS; TUMOR CELLS, CULTURED;

EID: 0034032289     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00261-1     Document Type: Article

References (48)

1. Abrahamson M., Ritonja A., Brown M., Grubb A., Machleidt W., Barrett A.J. Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem. 262:1987;9688-9694.
2. Barrett A.J., Kembhavi A.A., Brown M.A., Kirschke H., Knight C.G., Tamai M., Hanada K. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J. 201:1982;189-198.
3. Barrett A.J., Fritz H., Grubb A., Isemura S., Järvinen M., Katunuma N., Machleidt W., Muller-Esterl W., Sasaki M., Turk V. Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin. Biochem J. 236:1986;312.
4. Bode W., Engh R., Musil D., Thiele U., Huber R., Karshikov A., Brzin J., Kos J., Turk V. The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. Eur Med Biol Org J. 7:1988;2593-2599.
5. Bossard M.J., Tomaszek T.A., Thompson S.K., Amegadzie B.Y., Hanning C.R., Jones C., Kurdyla J.T., McNulty D.E., Drake F.H., Gowen M., Levy M.A. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem. 271:1996;12517-12524.
6. Brand J.S., Raisz L.G. Effect of thyrocalcitonin and phosphate ion on the parathyroid hormone stimulated resorption. Endocrinology. 90:1972;479-487.
7. Brömme D., Okamoto K. Human cathepsin O2, a novel cysteine proteinase highly expressed in osteoclastomas and ovary. Molecular cloning, sequencing and tissue distribution. Biol Chem Hoppe-Seyler. 376:1995;379-384.
8. Chen P.S., Toribara T.Y., Warner H. Microdetermination of phosphorus. Anal Chem. 28:1956;1758-1768.
9. Dalböge H., Jensen E.B., Töttrup H., Grubb A., Abrahamson M., Olafsson I., Carlsen S. High-level expression of active human cystatin C in Escherichia coli. Gene. 79:1989;325-332.
10. Delaissé J.M., Boyde A., Maconnachie E., Ali N.N., Sear C.H.J., Eeckhout Y., Vaes G., Jones S.J. The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts. Bone. 8:1987;305-313.
11. Delaissé J.M., Eeckhout Y., Vaes G. Inhibition of bone resorption in culture by inhibitors of thiol proteinases. Biochem J. 192:1980;365-368.
12. Delaissé J.M., Eeckhout Y., Vaes G. In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption. Biochem Biophys Res Commun. 125:1984;441-447.
13. Delaissé J.-M., Ledent P., Vaes G. Collagenolytic cysteine proteinases of bone tissue. Biochem J. 279:1991;167-174.
14. Drake F.H., Dodds R.A., James I.E., Connor J.R., Debouck C., Richardson S., Lee-Rykaczewski E., Coleman L., Rieman D., Barthlow R., Hastings G., Gowen M. Cathepsin K., but not cathepsin B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem. 271:1996;12511-12516.
15. Everts V., Aronson D.C., Beertsen W. Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis. Calcif Tissue Int. 37:1985;25-31.
16. Everts V., Delaissé J.-M., Korper W., Niehof A., Vaes G., Beertsen W. Degradation of collagen in the bone-resorbing compartment underlying the osteoclasts involves both cysteine-proteinases and matrix metalloproteinases. J Cell Physiol. 150:1992;221-231.
17. Gelb B.D., Shi G.-P., Chapman H.A., Desnick R.J. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science. 273:1996;1236-1238.
18. Goto T., Kiyoshima T., Moroi R., Tsukuba T., Nishimura Y., Himeno M., Yamamoto K., Tanaka T. Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and electron microscopy. Histochemistry. 101:1994;33-40.
19. Goto T., Tsukuba T., Kiyoshima T., Nishimura Y., Kato K., Yamamoto K., Tanaka T. Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast. Histochemistry. 99:1993;411-414.
20. Grubb, A. In: Haeberli, A., Ed. Human Protein Data. Weinheim: VCH; 1993.
21. Hall A., Abrahamson M., Grubb A., Trojnar J., Kania P., Kasprzykowska R., Kasprzykowski F. Cystatin C based peptidyl diazomethanes as cysteine proteinase inhibitors Influence of the peptidyl chain length . J Enz Inhib. 6:1995;113-123.
22. Hall A., Håkansson K., Mason R.W., Grubb A., Abrahamson M. Structural basis for the biological specificity of cystatin C. J Biol Chem. 270:1995;5115-5121.
23. Hill P.A., Buttle D.A., Jones S.J., Boyde A., Murata M., Reynolds J.J., Meikle M.C. Inhibition of bone resorption by selective inactivators of cysteine proteinases. J Cell Biochem. 56:1994;118-130.
24. Inaoka T., Bilbe G., Ishibashi O., Tezuka K.-I., Kumegawa M., Kokubo T. Molecular cloning of human cDNA for cathepsin K Novel cysteine proteinase predominantly expressed in bone . Biochem Biophys Res Commun. 206:1995;89-96.
25. Inui T., Ishibashi O., Inaoka T., Origane Y., Kumegawa M., Kokubo T., Yamamura T. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. J Biol Chem. 272:1997;8109-8112.
26. Jeppsson J.D., Laurell C.B., Franzén B. Agarose gel electrophoresis. Clin Chem. 25:1979;629-638.
27. Kakegawa H., Nikawa T., Tagami K., Kamioka H., Sumitani K., Kawata T., Drobnic-Kosorok M., Lenarcic B., Turk V., Katunuma N. Participation of cathepsin L on bone resorption. FEBS Lett. 321:1993;247-250.
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the need of bacteriophage T4. Nature. 227:1970;680-685.
29. Lerner U.H. Modifications of the mouse calvarial technique improve the responsiveness to stimulators of bone resorption. J Bone Miner Res. 2:1987;375-383.
30. Lerner U.H., Grubb A. Human cystatin C, a cysteine proteinase inhibitor inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy. J Bone Miner Res. 7:1992;433-440.
31. Lerner U.H., Johansson L., Ransjö M., Rosenquist J.B., Reinholt F.P., Grubb A. Cystatin C, an inhibitor of bone resorption produced by osteoblasts. Acta Physiol Scand. 161:1997;81-92.
32. Leung-Tack J., Tavera C., Gensac M.C., Martinez J., Colle A. Modulation of phagotycosis-associated respiratory burst by human cystatin C Role of the N-terminal tetrapeptide Lys-Pro-Pro-Arg . Exp Cell Res. 188:1990;16-22.
33. Leung-Tack J., Tavera C., Martinez J., Colle A. Neutrophil chemotactic activity is modulated by human cystatin C, an inhibitor of cysteine proteases. Inflammation. 14:1990;247-258.
34. Ljunggren Ö., Ransjö M., Lerner U.H. In vitro studies on bone resorption in neonatal mouse calvariae using a modified dissection technique giving four samples of bone from each calvarium. J Bone Miner Res. 6:1991;543-550.
35. Page A.E., Warburton M.J., Chambers T.J., Pringle J.A.S., Hayman A.R. Collagenolytic cysteine proteinases of bone tissue. Biochim Biophys Acta. 1116:1992;57-66.
36. Rifkin B.R., Vernillo A.T., Kleckner A.P., Auszmann J.M., Rosenberg L.R., Zimmerman M. Cathepsin B and L activities in isolated osteoclasts. Biochem Biophys Res Commun. 179:1991;63-69.
37. Saftig P., Hunzicker E., Wehmeyer O., Jones S., Boyde A., Rommerskirch W., Moritz J.D., Schu P., von Figura K. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin K-deficient mice. Proc Natl Acad Sci USA. 95:1998;13453-13458.
38. Sannes P.L., Shofield B.H., McDonald D.F. Histochemical localization of cathepsin B, dipeptidyl peptidase I, and dipeptidyl peptidase II in rat bone. J Histochem Cytochem. 34:1986;983-988.
39. Sasaki T., Ueno-Matsuda E. Cysteine-proteinase localization in osteoclasts An immunohistochemical study . Cell Tissue Res. 271:1993;177-179.
40. Shi G.-P., Chapman H.A., Bhairi S.M., DeLeeuw C., Reddy V.Y., Weiss S.J. Molecular cloning of human cathepsin O, a novel endopeptidase and homologue of rabbit OC2. FEBS Lett. 357:1995;129-134.
41. Suda T., Takahashi N., Martin T.J. Cells of bone Osteoclast generation . Bilizikian J.P., Raisz L.G., Rodan G.A. Principles of Bone Biology. 1996;97-102 Academic, New York.
42. Tezuka K.-I., Tezuka Y., Maejima A., Sato T., Nemoto K., Kamioka H., Hakeda Y., Kumegawa M. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J Biol Chem. 269:1994;1106-1109.
43. Thompson S.K., Halbert S.M., Bossard M.J., Tomaszek T.A., Levy M.A., Zhao B., Smith W.W., Abdel-Meguid S.S., Janson C.A., D'Alessio K.J., McQueney M.S., Amegadzie B.Y., Hanning C.R., DesJarlais R.L., Briand J., Sarkar S.K., Huddleston M.M., Ijames C.F., Carr S.A., Garnes K.T., Shu A., Heys J.R., Bradbeer J., Zembryki D., Lee-Rykaczewski L., James I.E., Lark M.W., Drake F.H., Gowen M., Gleason J.G., Veber D.F. Design of active and selective human cathepsin K inhibitors that span the active site. Proc Natl Acad Sci USA. 94:1997;14249-14254.
44. Vaananen K. Osteoclast function Biology and mechanisms . Bilzikian J.P., Raisz L.G., Rodan G.A. Principles of Bone Biology. 1996;103-114 Academic, New York.
45. Verdot L., Lalmanach G., Vercruysse V., Hartman S., Lucius R., Hoebeke J., Gauthier F., Vray B. Cystatins up-regulate nitric oxide release from interferon-gamma-activated mouse peritoneal macrophages. J Biol Chem. 271:1996;28077-28081.
46. Votta B.J., Levy M.A.A., Bradbeer J., Dodds R.A., James I.E., Thompson S., Bossard M.J., Carr T., Connor J.R., Tomaszek T.A., Szewczuk L., Drake F.H., Veber D.F., Gowen M. Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo. J Bone Miner Res. 12:1997;1396-1406.
47. Wener J.A., Gorton S.J., Raisz L.G. Escape from inhibition of resorption in cultures of fetal bone treated with calcitonin and parathyroid hormone. Endocrinology. 90:1972;752-759.
48. Willis J.B. Atomic absorption spectrometry. Mavrodineanu R. Analytical Flame Spectroscopy. 1970;525-594 Philips Technical Library, Eindhoven, The Netherlands.