Pocket 4 in the HLA-DRB1 antigen-binding groove: An association with atopy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 55, Issue 4, 2000, Pages 398-401

  Torres Galván, María José ^a   Quiralte, J ^b   Blanco, C ^a   Castillo, R ^a   Carrillo, T ^a   Perez Aciego P ^a   Sanchez Garcia F ^a  

^a HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^b Hosp Univ Ciudad de Jaén   (Spain)

Author keywords

Atopy; Dermatophagoides pteronyssinus; Genetic markers; HLA DRB1; Pocket 4

Indexed keywords

ALLERGEN; HLA DR ANTIGEN;

ADULT; ALLELE; ARTICLE; ATOPY; DERMATOPHAGOIDES PTERONYSSINUS; FEMALE; GENETIC MARKER; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; ALLERGENS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CONJUNCTIVITIS; DNA; FEMALE; GENE FREQUENCY; GENES, MHC CLASS II; GLYCOPROTEINS; HLA-DR ANTIGENS; HUMANS; MALE; MITES; POLYMERASE CHAIN REACTION; RHINITIS, ALLERGIC, PERENNIAL;

EID: 0034027767     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2000.00524.x     Document Type: Article

References (20)

1. 1. GARCÍA-RAMOS ALONSO E, FERNÁNDEZ-CALDAS E, SELEZNICK MJ, LOCKEY RF. Respiratory allergies and skin test reactivity in high school students in Tenerife, Canary Islands, Spain. J Investig Allergol Clin Immunol 1992;2:19-26.
2. 2. GARCÍA ROBAINA JC, TORRE MORÍN F, BONNET MORENO CG, ANTOLÍN ARIAS J, PÉREZ SANTOS C, SÁNCHEZ COVISA A. House dust mites and Der p I in Tenerife (Canary Islands, Spain): the relative importance of other non-Dermatophagoides spp mites. Allergol Immunopathol (Madr) I996;24:135-138.
3. 3. SÁNCHEZ PALACIOS A, SCHAMANN F, GARCÍA JA, SÁNCHEZ MA. Epidemiological aspects of asthma in the Canary Islands. J Investig Allergol Clin Immunol 1997;7:298-299.
4. 4. BOUSQUET J, BURNEY P. Evidence for an increase in atopic disease and possible causes. Clin Exp Allergy 1993;23:484-492.
5. 5. LAU S, FALKENHORST G, WEBER A, et al. High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. J Allergy Clin Immunol 1989;84:718-725.
6. 6. SPORIK R, HOLGATE ST, PLATTS-MILLS TA, COGSWELL JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med I990;323:502-507.
7. 7. YOUNG RP, HART BJ, MERRETT TG, READ AF, HOPKIN JM. House dust mite sensitivity: interaction of genetics and allergen dosage. Clin Exp Allergy 1992;22:205-211.
8. 8. HUANG SK, ZWOLLO P, MARSH DG. Class II major histocompatibility complex restriction of human T cell responses to short ragweed allergen, Amb a V. Eur J Immunol 1991;21:1469-1473.
9. 9. FREIDHOFF LR, EHRLICH E, MEYERS DA, ANSARI AA, BIAS WB, MARSH DG. Association of HLA-DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects. Tissue Antigens 1988;31:211-219.
10. 10. CÁRDABA B, VILCHES C, MARTÍN E, et al. DR7 and DQ2 are positively associated with immunoglobulin-E response to the main antigen of olive pollen (Ole e I) in allergic patients. Hum Immunol 1993;38:293--299.
11. 11. YOUNG RP, DEKKER JW, WORDSWORTH BP, et al. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994;24:431-439.
12. 12. HOLLOWAY JW, DOULL T, BEGISHVILI B, BEASLEY R, HOLGATE ST, HOWELL WM. Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy. Clin Exp Allergy 1996;26:1142-1149.
13. 13. STEPHAN V, SCHMID V, FRISCHER T, et al. Mite allergy, clinical atopy, and restriction by HLA class II immune response genes. Pediatr Allergy Immunol 1996;7:28-34.
14. 14. LARA-MÁRQUEZ ML, YUNIS JJ, LAYRISSE Z, et al. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoidea spp.-sensitive asthma in a sample of the Venezuelan population. Clin Exp Allergy 1999;29:60-71.
15. 15. TORRES-GALVÁN MJ, QUIRALTE J, BLANCO C, et al. Linkage of house dust mite allergy with the HLA region. Ann Allergy Asthma Immunol 1999;82:198-203.
16. 16. VERHOEF A, HIGGINS JA, THORPE CJ, et al. Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993;5:1589-1597.
17. 17. HIGGINS JA, THORPE CJ, HAYBALL JD, O'HEHIR RE, LAMB JR. Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and -DR class II molecules. J Allergy Clin Immunol 1994;93:891-899.
18. 18. STERN LJ, BROWN JH, JARDETZKY TS, et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994;368:215-221.
19. 19. FU XT, BONO CP, WOULFE SL, et al. Pocket 4 of the HLA-DR(αβ1*0401) molecule is a major determinant of T cell recognition of peptide. J Exp Med I995;181:915-926.
20. 20. OU D, MITCHELL LA, TINGLE AJ. A new categorization of HLA-DR alleles on a functional basis. Hum Immunol I998;59:665-676.