The ubiquitin/proteasome pathway;Le systeme ubiquitine/proteasome: Un ensemble (de) complexe(s) pour degrader les proteines

Medecine/Sciences

Volumn 16, Issue 5, 2000, Pages 623-629

  Coux, Olivier ^a   Piechaczyk, Marc ^b  

^a CNRS   (France)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PEPTIDE; PROTEASOME; UBIQUITIN;

APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL STIMULATION; COVALENT BOND; NONHUMAN; PROTEIN DEGRADATION; REVIEW;

EUKARYOTA;

EID: 0034027286     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/1705     Document Type: Review

References (24)

1. Ciechanover A, Schwartz AL. The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci USA 1998; 95: 2727-30.
2. Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998; 67: 425-79.
3. Margottin F, Lassot I, Durand H, et al. Phosphorylation et ciblage au protéasome: la F-box connection. Med Sci 1999; 15: 1008-14.
4. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993; 75: 495-505.
5. Hicke L. Gettin' down with ubiquitin : turning off cell-surface receptors, transporters and channels. Trends Cell Biol 1999; 9: 107-12.
6. Beaudenon SL, Huacani MR, Wang G, McDonnell DP, Huibregtse JM. Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in saccharomyces cerevisiae. Mol Cell Biol 1999; 19: 6972-9.
7. Marti A, Wirbelauer C, Scheffner M, Krek W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. 1999; 1: 14-9.
8. Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W. The von hippel-lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev 1999; 13: 1822-33.
9. Singer JD, Gurian-West M, Clurman B, Roberts JM. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev 1999; 13: 2375-87.
10. Zachariae W, Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 1999; 13: 2039-58.
11. Varshavsky A. The N-end rule pathway of protein degradation. Genes Cells 1997; 2: 13-28.
12. Bordallo J, Plemper RK, Finger A, Wolf DH. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 1998; 9: 209-22.
13. Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420: 25-7.
14. Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-Dependent ubiquitin-protein Ligase. Science 1999; 286: 309-12.
15. Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci USA 1999; 96: 11364-9.
16. Coux O, Tanaka K, Goldberg AL. Structure and Functions of the 20S and 26S proteasomes. Annu Rev Biochem 1996; 65: 801-47.
17. Voges D, Zwickl P, Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 1999; 68: 1015-68.
18. Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 1998; 8: 397-403.
19. Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol 1999; 17: 739-79.
20. Braun BC, Glickman M, Kraft R, et al. The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol 1999; 1: 221-6.
21. Kam YA, Xu W, Demartino GN, Cohen RE. Editing of ubiquitin conjugates by an isopeptidase In the 26S proteasome. Nature 1997; 385: 737-740.
22. Schwartz AL, Ciechanover A. The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 1999; 50: 57-74.
23. Adams J, Palombella VJ, Sausville EA. et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999; 59: 2615-22.
24. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 1999; 96: 635-44.