A two-dimensional gel electrophoretic study of proteins synthesized and released by degenerating adult mouse sciatic nerve

Experimental Neurology

Volumn 162, Issue 1, 2000, Pages 194-200

  Golding, Jon P ^a   Tonge, David ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

2 D gel electrophoresis; Degeneration; Isoelectric point; Molecular weight; PNS; Protein secretion; Protein synthesis; Regeneration

Indexed keywords

NERVE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FEMALE; ISOELECTRIC POINT; MOLECULAR WEIGHT; MOUSE; NERVE DEGENERATION; NERVE FIBER REGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; PROTEIN SYNTHESIS; SCIATIC NERVE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 0034025534     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7332     Document Type: Article

References (43)

1. Aamar S., Saada A., Rotshenker S. Lesion-induced changes in the production of newly synthesized and secreted Apo-E and other molecules are independent of the concomitant recruitment of blood-borne macrophages into injured nerves. J. Neurochem. 59:1992;1287-1292.
2. Aaronson O. S., Golding J. P., Tonge D. A. Oriented growth of regenerating axons in axolotl forelimbs is consistent with guidance by diffusible factors from distal nerve stumps. Neuroscience. 66:1995;201-213.
3. Bates D. J., Mangelsdorf D. C., Ridings J. A. Multiple neurotrophic factors including NGF-like activity in nerve regeneration chamber fluids. Neurochem. Int. 26:1995;281-293.
4. Berry M., Carlisle J., Hunter A. Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J. Neurocytol. 25:1996;147-170.
5. Cajal S. R. May R. M. Degeneration and Regeneration of the Nervous System. 1928;Oxford Univ. Press, London.
6. Cho E. Y. P., So K. F. Characterisation of the sprouting response of axon-like processes from retinal ganglion cells after axotomy in adult hamsters: A model using intravitreal implantation of a peripheral nerve. J. Neurocytol. 21:1992;589-603.
7. Curtis R., Scherer S. S., Somogyi R., Adryan K. M., Ip N. Y., Zhu Y., Lindsay R. M., Distefano P. S. Retrograde axonal-transport of LIF is increased by peripheral-nerve injury - Correlation with increased LIF expression in distal nerve. Neuron. 12:1994;191-204.
8. De Leon M., Nahin R. L., Molina C. A., De Leon D. D., Ruda M. A. Comparison of c-jun, junB, and junD mRNA expression and protein in the rat dorsal root ganglia following sciatic nerve transection. J. Neurosci. Res. 42:1995;391-401.
9. Diamond J., Foester A., Holmes M., Coughlin M. Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF. J. Neurosci. 12:1992;1467-1476.
10. Ebadi M., Bashir R. M., Heidrick M. L., Hamada F. M., Elrefaey H., Hamed A., Helal G., Baxi M. D., Cerutis D. R., Lassi N. K. Neurotrophins and their receptors in nerve injury and repair. Neurochem. Int. 30:1997;347-374.
11. Edbladh M., Tonge D. A., Golding J., Ekstrom P. A. R., Edstrom A. Early regeneration in vitro of adult mouse sciatic axons is dependent on local protein synthesis but may not involve neurotrophins. Neurosci. Lett. 168:1994;37-40.
12. Edstrom A., Ekstrom P. A. R., Tonge D. Axonal outgrowth and neuronal apoptosis in cultured adult mouse dorsal root ganglion preparations: Effects of neurotrophins, of inhibition of neurotrophin actions and of prior axotomy. Neuroscience. 75:1996;1165-1174.
13. Ferguson I. A., Williams R., Rush R. A. Chicken NGF and non-NGF trophic factor synthesis and release by sciatic nerves in vitro. J. Neurosci. Res. 22:1989;408-417.
14. Funakoshi H., Frisen J., Barbany G., Timmusk T., Zachrisson O., Verge V. M. K., Persson H. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123:1993;455-465.
15. Gillen C., Gleichmann M., Spreyer P., Muller H. W. Differentially expressed genes after peripheral nerve injury. J. Neurosci. Res. 42:1995;159-171.
16. Golding J. P., Tonge D. A. Protein synthesis and release by normal and lesioned axolotl peripheral nerves. Exp. Neurol. 134:1995;94-101.
17. Gu X. S., Thomas P. K., King R. H. M. Chemotropism in nerve regeneration studied in tissue culture. J. Anat. 186:1995;153-163.
18. Hall S. M. Regeneration in cellular and acellular autografts in the peripheral nervous system. Neuropathol. Appl. Neurobiol. 12:1986;27-46.
19. Handelmann G. E., Boyles J. K., Weisgraber K. H., Mahley R. W., Pitas R. E. Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on extension of neurites by rabbit dorsal root ganglion neurons in vitro. J. Lipid Res. 33:1992;1677-1688.
20. Ignatius M. J., Gebicke-Harter P. J., Skene J. H., Schilling J. W., Weisgraber K. H., Mahley R. W., Shooter E. M. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc. Natl. Acad. Sci. USA. 83:1986;1125-1129.
21. Ishii D. N., Glazner G. W., Pu S. F. Role of insulin-like growth factors in peripheral nerve regeneration. Pharmacol. Ther. 62:1994;125-144.
22. Jo S. A., Wang E., Benowitz L. I. Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. Neuroscience. 89:1998;579-591.
23. Kuffler D. P., Megwinoff O. Neurotrophic influence of denervated sciatic nerve on adult dorsal root ganglion neurons. J. Neurobiol. 25:1994;1267-1282.
24. Le Beau J. M., Lacorbiere M., Powell H. C., Ellisman M. H., Schubert D. Extracellular fluid conditioned during peripheral nerve regeneration stimulates Schwann cell adhesion, migration and proliferation. Brain Res. 459:1988;93-104.
25. Lindholm D., Heumann R., Meyer M., Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells. Nature. 330:1987;658-659.
26. Longo F. M., Hayman E. G., Davis G. E., Ruoslahti E., Engvall E., Manthorpe M., Varon S. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res. 309:1984;105-117.
27. Longo F. M., Skaper S. D., Manthorpe M., Williams L. R., Lundborg G., Varon S. Temporal changes of neurotrophic activities accumulating in vivo within nerve regeneration chambers. Exp. Neurol. 81:1983;756-769.
28. Mahley R. W. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science. 240:1988;622-630.
29. McMahon S. B., Armanini M. P., Ling L. H., Phillips H. S. Expression and co-expression of Trk receptors in sub-populations of adult primary sensory neurons projecting to identified peripheral targets. Neuron. 12:1994;1161-1171.
30. Meyer M., Matsuoka I., Wetmore C., Olsen L., Thoenen H. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119:1992;45-54.
31. Muller H. W., Ignatius M. J., Hangen D. H., Shooter E. M. Expression of specific sheath cell proteins during peripheral nerve growth and regeneration in mammals. J. Cell Biol. 102:1986;393-402.
32. Nadim W., Anderson P. N., Turmaine M. The role of Schwann cells and basal lamina tubes in the regeneration of axons through long lengths of freeze-killed nerve grafts. Neuropathol. Appl. Neurobiol. 16:1990;411-421.
33. Nathan B. P., Bellosta S., Sanan D. A., Weisgrager K. H., Mahley R. W., Pitas R. E. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 264:1994;850-852.
34. Perry V. H., Brown M. C., Gordon S. The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. J. Exp. Med. 165:1987;1218-1223.
35. Politis M., Ederle K., Spencer P. S. Tropism in nerve regeneration in vivo. Attraction of regenerating axons by diffusible factors derived from cells in distal nerve stumps of transected peripheral nerves. Brain Res. 253:1982;1-12.
36. Popko B., Goodrum J. F., Bouldin T. W., Zhang S. H., Maeda N. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J. Neurochem. 60:1993;1155-1158.
37. Richardson P. M., Ebendal T. Nerve growth activities in rat peripheral nerve. Brain Res. 246:1982;57-64.
38. Righetti P. G. Isoelectric focusing: Theory, methodology and applications. Work T. S., Burdon R. H. Laboratory Techniques in Biochemistry and Molecular Biology. 1988;148-267 Elsevier, Amsterdam.
39. Schagger H., Von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:1987;368-379.
40. Tonge D. A., Aaronson O. S., Golding J. P., Jaggers D. Cellular migration and axonal outgrowth from adult mammalian peripheral nerves in vitro. J. Neurobiol. 29:1996;151-164.
41. Trupp M., Rydén M., Jörnvall H., Funakoshi H., Timmusk T., Arenas E., Ibanéz C. F. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol. 130:1995;137-148.
42. Williams L. R., Powell H. C., Lundborg G., Varon S. Competence of nerve tissue as distal insert promoting nerve regeneration in a silicone chamber. Brain Res. 293:1984;201-211.
43. Windebank A. J., Poduslo J. F. Neuronal growth factors produced by adult peripheral nerve after injury. Brain Res. 385:1986;197-200.