메뉴 건너뛰기




Volumn 75, Issue 4, 1996, Pages 1165-1174

Axonal outgrowth and neuronal apoptosis in cultured adult mouse dorsal root ganglion preparations: Effects of neurotrophins, of inhibition of neurotrophin actions and of prior axotomy

Author keywords

apoptosis; DRG; K 252a; mouse; neurotrophins; regeneration

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; K 252A; NERVE GROWTH FACTOR; NEUROTROPHIN 3; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

EID: 0030297807     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00324-7     Document Type: Article
Times cited : (59)

References (42)
  • 2
    • 0023789640 scopus 로고
    • Selective neuronal destruction by Ricinus communis agglutinin I and its use for the quantitative determination of sciatic nerve dorsal root ganglion cell numbers
    • 2. Aldskogius H., Wiesenfeld-Hallin Z. and Kristensson K. (1988) Selective neuronal destruction by Ricinus communis agglutinin I and its use for the quantitative determination of sciatic nerve dorsal root ganglion cell numbers. Brain Res. 461, 215-220.
    • (1988) Brain Res. , vol.461 , pp. 215-220
    • Aldskogius, H.1    Wiesenfeld-Hallin, Z.2    Kristensson, K.3
  • 3
    • 0028931552 scopus 로고
    • Neurotrophic factors and their receptors
    • 3. Barbacid M. (1995) Neurotrophic factors and their receptors. Curr. Opin. Cell Biol. 7, 148-155.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 148-155
    • Barbacid, M.1
  • 5
    • 0023415045 scopus 로고
    • Evidence that endogenous β-nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats
    • 5. Diamond J., Coughlin M., Macintyre L., Holmer M. and Vischaeu B. (1987) Evidence that endogenous β-nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats. Proc. natn. Acad. Sci. U.S.A. 84, 6596-6600.
    • (1987) Proc. Natn. Acad. Sci. U.S.A. , vol.84 , pp. 6596-6600
    • Diamond, J.1    Coughlin, M.2    Macintyre, L.3    Holmer, M.4    Vischaeu, B.5
  • 6
    • 0026559892 scopus 로고
    • Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF
    • 6. Diamond J., Foester A., Holmes M. and Coughlin M. (1992) Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF. J. Neurosci. 12, 1467-1476.
    • (1992) J. Neurosci. , vol.12 , pp. 1467-1476
    • Diamond, J.1    Foester, A.2    Holmes, M.3    Coughlin, M.4
  • 7
    • 0022621457 scopus 로고
    • Ecto-protein kinase activity on the external surface of neural cells
    • 7. Ehrlich Y. H., Davis T. B., Bock E., Kornecki E. and Lenox R. H. (1986) Ecto-protein kinase activity on the external surface of neural cells. Nature 320, 67-70.
    • (1986) Nature , vol.320 , pp. 67-70
    • Ehrlich, Y.H.1    Davis, T.B.2    Bock, E.3    Kornecki, E.4    Lenox, R.H.5
  • 8
    • 0029039160 scopus 로고
    • Neurones and glia cells of the mouse sciatic nerve undergo apoptosis after injury in vivo and in vitro
    • 8. Ekström P. A. R. (1995) Neurones and glia cells of the mouse sciatic nerve undergo apoptosis after injury in vivo and in vitro. NeuroReport 6, 1029-1032.
    • (1995) NeuroReport , vol.6 , pp. 1029-1032
    • Ekström, P.A.R.1
  • 9
    • 0027399026 scopus 로고
    • Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy
    • 9. Ernfors P., Rosario C. M., Merlio J.-P., Grant G., Alskogius H. and Persson H. (1993) Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. Molec. Brain Res. 17, 217-226.
    • (1993) Molec. Brain Res. , vol.17 , pp. 217-226
    • Ernfors, P.1    Rosario, C.M.2    Merlio, J.-P.3    Grant, G.4    Alskogius, H.5    Persson, H.6
  • 10
    • 0028274040 scopus 로고
    • Mice lacking brain-derived neurotrophic factor develop with sensory deficits
    • 10. Ernfors P., Lee K. F. and Jaenisch R. (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147-150.
    • (1994) Nature , vol.368 , pp. 147-150
    • Ernfors, P.1    Lee, K.F.2    Jaenisch, R.3
  • 12
    • 0027360908 scopus 로고
    • Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve
    • 12. Funakoshi H., Frisén J., Barnaby G., Timmusk T., Zachrisson O., Verge V. M. K. and Persson H. (1993) Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123, 455-465.
    • (1993) J. Cell Biol. , vol.123 , pp. 455-465
    • Funakoshi, H.1    Frisén, J.2    Barnaby, G.3    Timmusk, T.4    Zachrisson, O.5    Verge, V.M.K.6    Persson, H.7
  • 13
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • 13. Gavrieli Y., Sherman Y. and Ben-Sasson S. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.3
  • 14
    • 0025944712 scopus 로고
    • Regulation of axonal caliber, neurofilament content and nuclear localization in mature sensory neurons by nerve growth factor
    • 14. Gold B. G., Mobley W. C. and Matheson S. F. (1991) Regulation of axonal caliber, neurofilament content and nuclear localization in mature sensory neurons by nerve growth factor. J. Neurosci. 11, 943-955.
    • (1991) J. Neurosci. , vol.11 , pp. 943-955
    • Gold, B.G.1    Mobley, W.C.2    Matheson, S.F.3
  • 15
    • 0023256354 scopus 로고
    • Changes of nerve growth factor synthesis in non-neuronal cells in response to sciatic nerve transection
    • 15. Heumann R., Korsching S., Bandtlow C. and Thoenen H. (1987) Changes of nerve growth factor synthesis in non-neuronal cells in response to sciatic nerve transection. J. Cell Biol. 104, 1623-1631.
    • (1987) J. Cell Biol. , vol.104 , pp. 1623-1631
    • Heumann, R.1    Korsching, S.2    Bandtlow, C.3    Thoenen, H.4
  • 16
    • 0026088477 scopus 로고
    • NGF enhances neurite regeneration from nerve-transected terminals of young adult and aged mouse dorsal root ganglia in vitro
    • 16. Horie H., Bando Y., Chi H. and Takenaka T. (1991) NGF enhances neurite regeneration from nerve-transected terminals of young adult and aged mouse dorsal root ganglia in vitro. Neurosci. Lett. 121, 125-128.
    • (1991) Neurosci. Lett. , vol.121 , pp. 125-128
    • Horie, H.1    Bando, Y.2    Chi, H.3    Takenaka, T.4
  • 17
    • 0028607992 scopus 로고
    • Neurite outgrowth and GAP-43 mRNA expression in cultured adult rat dorsal root ganglion neurons: Effects of NGF or prior peripheral axotomy
    • 17. Hu-Tsai M., Winter J., Emson P. C. and Woolf C. J. (1994) Neurite outgrowth and GAP-43 mRNA expression in cultured adult rat dorsal root ganglion neurons: effects of NGF or prior peripheral axotomy. J. Neurosci. Res. 39, 634-645.
    • (1994) J. Neurosci. Res. , vol.39 , pp. 634-645
    • Hu-Tsai, M.1    Winter, J.2    Emson, P.C.3    Woolf, C.J.4
  • 18
    • 0027315407 scopus 로고
    • An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin
    • 18. Ibanez C. F., Hag L. L., Murray-Rust J. and Persson H. (1993) An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin. Eur. molec. Biol. Org. J. 12, 2281-2293.
    • (1993) Eur. Molec. Biol. Org. J. , vol.12 , pp. 2281-2293
    • Ibanez, C.F.1    Hag, L.L.2    Murray-Rust, J.3    Persson, H.4
  • 19
    • 0011991405 scopus 로고
    • K-252a, a potent inhibitor of protein kinase C from microbial origin
    • 19. Kase H., Iwahashi K. and Matsuda Y. (1986) K-252a, a potent inhibitor of protein kinase C from microbial origin. J. Antibiot., Tokyo 142, 436-440.
    • (1986) J. Antibiot., Tokyo , vol.142 , pp. 436-440
    • Kase, H.1    Iwahashi, K.2    Matsuda, Y.3
  • 20
    • 0028343266 scopus 로고
    • Role of neurotrophins in mouse neuronal development
    • 20. Klein R. (1994) Role of neurotrophins in mouse neuronal development. Proc. Fedn Am. Socs exp. Biol. 8, 738-744.
    • (1994) Proc. Fedn Am. Socs Exp. Biol. , vol.8 , pp. 738-744
    • Klein, R.1
  • 22
    • 0026314778 scopus 로고
    • K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons
    • 22. Knüsel B. and Hefti F. (1991) K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. J. Neurochem. 57, 955-962.
    • (1991) J. Neurochem. , vol.57 , pp. 955-962
    • Knüsel, B.1    Hefti, F.2
  • 23
    • 0029065517 scopus 로고
    • Potentiated necrosis of cultured cortical neurons by neurotrophins
    • 23. Koh J.-Y., Gwag J. G., Lobner D. and Choi D. W. (1995) Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268, 573-575.
    • (1995) Science , vol.268 , pp. 573-575
    • Koh, J.-Y.1    Gwag, J.G.2    Lobner, D.3    Choi, D.W.4
  • 25
    • 0023684176 scopus 로고
    • Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
    • 25. Lindsay R. M. (1988) Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J. Neurosci. 8, 2394-2408.
    • (1988) J. Neurosci. , vol.8 , pp. 2394-2408
    • Lindsay, R.M.1
  • 26
    • 0001423870 scopus 로고
    • The role of neurotrophic factors in functional maintenance of mature sensory neurons
    • (ed. Scott S. A.), Oxford University Press, New York
    • 26. Lindsay R. M. (1992) The role of neurotrophic factors in functional maintenance of mature sensory neurons. In Sensory Neurons. Development, Diversity, and Plasticity (ed. Scott S. A.), pp. 404-420. Oxford University Press, New York.
    • (1992) Sensory Neurons. Development, Diversity, and Plasticity , pp. 404-420
    • Lindsay, R.M.1
  • 27
    • 0028289478 scopus 로고
    • Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets
    • 27. McMahon S. B., Armanini M. P., Ling L. H. and Phillips H. S. (1994) Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12, 1161-1171.
    • (1994) Neuron , vol.12 , pp. 1161-1171
    • McMahon, S.B.1    Armanini, M.P.2    Ling, L.H.3    Phillips, H.S.4
  • 28
    • 0025986893 scopus 로고
    • Inhibition of nerve growth-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane
    • 28. Nagashima K., Nakanishi S. and Matsuda Y. (1991) Inhibition of nerve growth-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane. Fedn Eur. biochem. Socs Lett. 293, 119-123.
    • (1991) Fedn Eur. Biochem. Socs Lett. , vol.293 , pp. 119-123
    • Nagashima, K.1    Nakanishi, S.2    Matsuda, Y.3
  • 29
    • 0023475279 scopus 로고
    • Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia
    • 29. Otto D., Unsicker K. and Grothe C. (1987) Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia. Neurosci. Lett. 83, 156-160.
    • (1987) Neurosci. Lett. , vol.83 , pp. 156-160
    • Otto, D.1    Unsicker, K.2    Grothe, C.3
  • 30
    • 0027265263 scopus 로고
    • Peripheral nerve regeneration: Role of growth factors and their receptors
    • 30. Raivich G. and Kreutzberg G. W. (1993) Peripheral nerve regeneration: role of growth factors and their receptors. Int. J. devl Neurosci. 11, 311-324.
    • (1993) Int. J. Devl Neurosci. , vol.11 , pp. 311-324
    • Raivich, G.1    Kreutzberg, G.W.2
  • 31
    • 0023275887 scopus 로고
    • Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury
    • 31. Rich K. M., Luszczynski J. R., Osborne P. A. and Johnson E. M. (1987) Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury. J. Neurocytol. 16, 261-268.
    • (1987) J. Neurocytol. , vol.16 , pp. 261-268
    • Rich, K.M.1    Luszczynski, J.R.2    Osborne, P.A.3    Johnson, E.M.4
  • 32
    • 0019982746 scopus 로고
    • Nerve growth activities in rat peripheral nerve
    • 32. Richardson P. M. and Ebendal T. (1982) Nerve growth activities in rat peripheral nerve. Brain Res. 246, 57-64.
    • (1982) Brain Res. , vol.246 , pp. 57-64
    • Richardson, P.M.1    Ebendal, T.2
  • 33
    • 0028933576 scopus 로고
    • Effects of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice
    • 33. Schmidt Y., Unger J. W., Bartke I. and Reiter R. (1995) Effects of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice. Expl Neurol. 132, 16-23.
    • (1995) Expl Neurol. , vol.132 , pp. 16-23
    • Schmidt, Y.1    Unger, J.W.2    Bartke, I.3    Reiter, R.4
  • 34
    • 0027363111 scopus 로고
    • Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury
    • 34. Sebert M. E. and Shooter E. M. (1993) Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury. J. Neurosci. Res. 36, 357-367.
    • (1993) J. Neurosci. Res. , vol.36 , pp. 357-367
    • Sebert, M.E.1    Shooter, E.M.2
  • 35
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    • 35. Smeyne R. J., Klein R., Schnapp A., Long L. K., Bryant S., Lewin A., Lira S. A. and Barbacid M. (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368, 246-249.
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3    Long, L.K.4    Bryant, S.5    Lewin, A.6    Lira, S.A.7    Barbacid, M.8
  • 36
    • 0026563244 scopus 로고
    • K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
    • 36. Tapley P., Lamballe F. and Barbacid M. (1992) K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene 7, 371-381.
    • (1992) Oncogene , vol.7 , pp. 371-381
    • Tapley, P.1    Lamballe, F.2    Barbacid, M.3
  • 37
    • 0001768678 scopus 로고
    • An extracellular matrix extract (Matrigel) supports axonal growth of adult mammalian and amphibian sensory neurons in vitro
    • 37. Tonge D. A., Golding J. P., Edbladh M. and Edström A. (1994) An extracellular matrix extract (Matrigel) supports axonal growth of adult mammalian and amphibian sensory neurons in vitro. J. Physiol. 475, 4-5.
    • (1994) J. Physiol. , vol.475 , pp. 4-5
    • Tonge, D.A.1    Golding, J.P.2    Edbladh, M.3    Edström, A.4
  • 38
    • 0024549604 scopus 로고
    • Nerve growth factor receptors on normal and injured sensory neurons
    • 38. Verge V. M. K., Riopelle R. J. and Richardson P. M. (1989) Nerve growth factor receptors on normal and injured sensory neurons. J. Neurosci. 9, 914-922.
    • (1989) J. Neurosci. , vol.9 , pp. 914-922
    • Verge, V.M.K.1    Riopelle, R.J.2    Richardson, P.M.3
  • 39
    • 0025239360 scopus 로고
    • Correlation between GAP43 and nerve growth receptors in rat sensory neurons
    • 39. Verge V. M., Tetzlaff W., Richardson P. M. and Bisby M. A. (1990) Correlation between GAP43 and nerve growth receptors in rat sensory neurons. J. Neurosci. 10, 926-934.
    • (1990) J. Neurosci. , vol.10 , pp. 926-934
    • Verge, V.M.1    Tetzlaff, W.2    Richardson, P.M.3    Bisby, M.A.4
  • 40
    • 0028795367 scopus 로고
    • Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
    • 40. Wetmore C. and Olsen L. (1995) Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions. J. comp. Neurol. 353, 143-159.
    • (1995) J. Comp. Neurol. , vol.353 , pp. 143-159
    • Wetmore, C.1    Olsen, L.2
  • 41
    • 0000727279 scopus 로고
    • Degenerative and regenerative responses of sensory neurones to capsaicin-induced damage
    • (ed. Wood J.), Academic, London
    • 41. Winter J. and Woolf B. and Lynn B. (1993) Degenerative and regenerative responses of sensory neurones to capsaicin-induced damage. In Capsaicin in the Study of Pain (ed. Wood J.), pp. 139-160. Academic, London.
    • (1993) Capsaicin in the Study of Pain , pp. 139-160
    • Winter, J.1    Woolf, B.2    Lynn, B.3
  • 42
    • 0028936395 scopus 로고
    • Neurotrophin receptor expression defines distinct subpopulations of neurons in rat dorsal root ganglia
    • 42. Wright D. E. and Snider W. D. (1995) Neurotrophin receptor expression defines distinct subpopulations of neurons in rat dorsal root ganglia. J. comp. Neurol. 351, 329-338.
    • (1995) J. Comp. Neurol. , vol.351 , pp. 329-338
    • Wright, D.E.1    Snider, W.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.