Irniine, a pyrrolidine alkaloid, isolated from Arisarum vulgare can induce apoptosis and/or necrosis in rat hepatocyte cultures

Toxicon

Volumn 38, Issue 10, 2000, Pages 1389-1402

  Rakba, N ^a,b   Melhaoui, A ^b   Rissel, M ^a   Morel, I ^a   Loyer, P ^a   Lescoat, G ^a  

^a INSERM   (France)

^b FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Arisarum vulgare; Irniine; Liver cell toxicity; Pyrrolidine alkaloid

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALKALOID; ARISARUM VULGARE EXTRACT; DNA; IRNIINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PLANT EXTRACT; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ELECTRON MICROSCOPY; ENZYME RELEASE; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER CELL DAMAGE; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALKALOIDS; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA DAMAGE; ELECTROPHORESIS, AGAR GEL; EPITHELIAL CELLS; L-LACTATE DEHYDROGENASE; LIVER; MALE; MALONDIALDEHYDE; MITOCHONDRIA; NECROSIS; NEUTRAL RED; PLANTS, TOXIC; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS; THIAZOLES;

ANIMALIA; ARISARUM VULGARE;

EID: 0034025040     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(99)00232-9     Document Type: Article

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