Interaction between the serotoninergic and dopaminergic systems in d- fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1363-1373

  Gardier, A M ^a,c   Moratalla, R ^d,e   Cuellar B ^d   Sacerdote, M ^d   Guibert, B ^a   Lebrec, H ^b   Graybiel, A M ^e  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^d INSTITUTO CAJAL   (Spain)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

C Fos; Dexfenfluramine; Dynorphin; Jun B; P Chloroamphetamine; Striatum

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CHLORAMPHETAMINE; COCAINE; DEXFENFLURAMINE; DOPAMINE; DYNORPHIN; METITEPINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SEROTONIN; SEROTONIN 1 ANTAGONIST;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG BINDING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONIN RELEASE; SURVIVAL TIME;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; COCAINE; CORPUS STRIATUM; DOPAMINE; DOPAMINE ANTAGONISTS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DYNORPHINS; FENFLURAMINE; GENE EXPRESSION; MALE; METHIOTHEPIN; NEURONS; P-CHLOROAMPHETAMINE; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN; SEROTONIN AGENTS; SEROTONIN ANTAGONISTS; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 0034022075     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741363.x     Document Type: Article

References (57)

1. Appel N. M., Owens M. J., Culp S., Zaczek R., Contrera J. F., Bissette G., Nemeroff C. B., and De Souza E. B. (1991) Role of brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats. Endocrinology 128, 3237-3246.
2. Auerbach S. B., Minzenberg M. J., and Wilkinson L. O. (1989) Extracellular serotonin and 5-hydroxyindoleacetic acid in hypothalamus of the unanesthetized rat measured by in vivo dialysis coupled to high-performance liquid chromatography with electrochemical detection: dialysate serotonin reflects neuronal release. Brain Res. 499, 281-290.
3. Balcioglu A. and Wurtman R. J. (1998) Dexfenfluramine enhances striatal dopamine release in conscious rats via a serotoninergic mechanism. J. Pharmacol. Exp. Ther. 284, 991-997.
4. Benloucif S. B. and Galloway M. P. (1991) Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis. Eur. J. Pharmacol. 200, 1-8.
5. Benloucif S. B., Keegan M. J., and Galloway M. P. (1993) Serotonin-facilitated dopamine release in vivo: pharmacological characterization. J. Pharm. Pharmacol. 265, 373-377.
6. Berretta S., Robertson H. A., and Graybiel A. M. (1992) Dopamine and glutamate agonists stimulate neuron-specific expression of Foslike protein in the striatum. J. Neurophysiol. 68, 767-777.
7. Bettini E., Ceci A., Spinelli R., and Samanin R. (1987) Neuroleptic-like effects of the l-isomer of fenfluramine on striatal dopamine release in freely moving rats. Biochem. Pharmacol. 36, 2387-2391.
8. Bhat R. V. and Baraban J. M. (1993) Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. J. Pharmacol Exp. Ther. 267, 496-505.
9. Bischoff S., Heinrich M., Sonntag J.-M., and Krauss J. (1986) The D-1 dopamine receptor antagonist SCH23390 also interacts potently with brain serotonin (5-HT2) receptors. Eur. J. Pharmacol. 129, 367-370.
10. Bouaboula M., Legoux P., Pességué B., Delpech B., Dumont X., Piechaczyk M., Casellas P., and Shire D. (1992) Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control. J. Biol. Chem. 267, 21830-21838.
11. Boulenguez P., Rawlins J. N. P., Chauveau J., Joseph M. H., Mitchell S. N., and Gray J. A. (1996) Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway. Neuropharmacology 35, 1521-1529.
12. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
13. Cook D. F. and Wirtshafter D. (1998) Quinpirole attenuates c-fos induction by 5-HT, opioid and muscarinic receptor agonists. Eur. J. Pharmacol. 349, 41-47.
14. Crunelli V., Bernasconi S., and Samanin R. (1980) Effects of d- and l-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin. Pharmacol. Res. Commun. 12, 215-223.
15. 3H]i-mipramine. J. Pharmacol Exp. Ther. 242, 364-371.
16. Dawson T. M., Bredt D. S., Fotuhi M., Hwang P. M., and Snyder S. H. R. (1991) Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissue. Proc. Natl. Acad. Sci. USA 88, 7797-7801.
17. De Deurwaerdère P., Bonhomme N., Le Moal M., and Spampinato U. (1995) d-Fenfluramine increases striatal extracellular dopamine in vivo independently of serotonergic terminals or dopamine uptake sites. J. Neurochem. 65, 1100-1108.
18. 1B binding sites. Naunyn Schmiedebergs Arch. Pharmacol. 357, 1-7.
19. Garattini S., Buczko W., Jori A., and Samanin R. (1975) On the mechanism of action of fenfluramine. Postgrad. Med. J. 51, 27.
20. Gardier A. M., Kaakkola S., Erfurth A., and Wurtman R. J. (1992) Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotoninergic drugs. Brain Res. 588, 67-74.
21. Gardier A. M., Lepoul E., Chanut E., Trouvin J. H. R., and Jacquot C. (1994) Changes in dopamine metabolism in rat forebrain regions after cessation of long-term fluoxetine treatment: correlation with brain concentrations of fluoxetine and norfluoxetine. Life Sci. 54, 51-56.
22. Gerfen C. R., Engber T. M., Mahan L. C., Susel Z., Chase T. N., Monsma F. J. Jr., and Sibley D. R. (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250, 1429-1432.
23. 3H]dopa in various regions of the brain. J. Neurochem. 13, 655-669.
24. Graybiel A. M. and Moratalla R. (1989) Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments. Proc. Natl. Acad. Sci. USA 86, 9020-9024.
25. Graybiel A. M., Moratalla R., and Robertson H. A. (1990) Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl. Acad. Sci. USA 87, 6912-6916.
26. Guerra M. J., Liste I., and Labandeira-Garcia J. L. (1998) Interaction between the serotoninergic, dopaminergic and glutamatergic systems in fenfluramine-induced Fos expression in striatal neurons. Synapse 28, 71-82.
27. Hughes P. and Dragunow M. (1995) Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev. 47, 133-178.
28. Invernizzi R., Berettera C., Garattini S., and Samanin R. (1986) d- and l-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat. Eur. J. Pharmacol. 120, 9-17.
29. Javed A., Van de Kar L. D., and Gray T. S. (1998) The 5-HT1A and 5-HT2A/2C receptor antagonists WAY 100635 and ritanserin do not attenuate d-fenfluramine-induced Fos expression in the brain. Brain Res. 791, 67-74.
30. Jori A. and Bernardi D. (1972) Further studies on the increase of striatal homovanillic acid induced by amphetamine and fenfluramine. Eur. J. Pharmacol. 19, 276-280.
31. Kerdine S., Lebrec H., Bertoglio J., and Pallardy M. (1996) Interleukin-4 plays a dominant role in Th1-or Th2-like responses during the primary immune response to the hapten penicillin. Mol. Immunol. 33, 71-77.
32. Kirby L. G., Kreiss D. S., Singh A., and Lucki I. (1995) Effect of destruction of serotonin neurons on basal and fenfluramine-induced serotonin release in striatum. Synapse 20, 99-105.
33. Laferrere B. and Wurtman R. J. (1989) Effect of dexfenfluramine on serotonin release in brain of anesthetized rats. Brain Res. 504, 258-263.
34. Leslie R. A., Moorman J. M., and Grahame-Smith D. G. (1993a) Lithium enhances 5-HT2A receptor-mediated c-fos expression in rat cerebral cortex. Neuroreport 5, 241-244.
35. 2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres. Neuroscience 53, 457-463.
36. Li B.-H. and Rowland N. E. (1993) Dexfenfluramine induces Fos-like immunoreactivity in discrete brain regions in rats. Brain Res. Bull. 31, 43-48.
37. Li B.-H., Spector A. C., and Rowland N. E. (1994) Reversal of dexfenfluramine-induced anorexia and c-fos/c-jun expression by lesion in the lateral parabrachial nucleus. Brain Res. 640, 255-267.
38. Lucas J. J., Segu L., and Hen R. (1997) 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Mol. Pharmacol 51, 755-763.
39. Lucas J. J., Yamamoto A., Scearce-Levie K., Saudou F., and Hen R. (1998) Absence of fenfluramine-induced anorexia and reduced c-fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knockout mice. J. Neurosci. 18, 5537-5544.
40. McGeorge A. J. and Faull R. L. M. K. (1989) The organisation of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29, 503-537.
41. Moratalla R., Vickers E. A., Robertson H. A., Cochran B. H., and Graybiel A. M. (1993) Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaine. J. Neurosci. 13, 423-433.
42. Moratalla R., Elibol B., Vallejo M., and Graybiel A. M. (1996a) Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron 17, 147-156.
43. 1 dopamine receptor. Proc. Natl. Acad. Sci. USA 93, 14928-14933.
44. Richard D., Rivest S., and Rivier C. (1992) The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain. Brain Res. 594, 131-137.
45. Rouillard C., Bovetto S., Gervais J., and Richard D. (1996) Fenfluramine-induced activation of the immediate-early gene c-fos in the striatum: possible interaction between serotonin and dopamine. Mol. Brain Res. 37, 105-115.
46. Sabol K. E., Richards J. B., and Seiden L. S. (1992) Fluoxetine attenuates the D,L-fenfluramine-induced increase in extracellular serotonin as measured by in vivo microdialysis. Brain Res. 529, 294-301.
47. Samanin R. and Garattini S. (1990) The pharmacology of serotoninergic drugs affecting appetite, in Nutrition and the Brain, Vol. 8 (Wurtman R. J. and Wurtman J. J., eds), pp. 163-192. Raven Press, New York.
48. Simpson C. S. and Morris B. J. (1994) Haloperidol and fluphenazine induce junB gene expression in rat striatum and nucleus accumbens. J. Neurochem. 63, 1955-1961.
49. Soubrié P., Reisine T. D., and Glowinski J. (1984) Functional aspects of serotonin transmission in the basal ganglia: a review and in vivo approach using push-pull cannula technique. Neuroscience 13, 605-625.
50. Steinbusch H. W. (1984) Serotonin-immunoreactive neurons and their projections in the CNS, in Handbook of Chemical Neuroanatomy, Vol. 3 (Björklund A. and Hökfelt T., eds), pp. 68-125. Elsevier, New York.
51. Torres G. (1995) Fenfluramine-induced c-fos in the striatum and hypothalamus: a tract-tracing study. Neuroreport 6, 1679-1683.
52. Torres G. and Rivier C. (1993) Regional effects of NMDA receptor antagonists on the induction of striatal c-fos by fenfluramine. Mol. Cell Neurosci. 4, 231-236.
53. Torres G. and Rivier C. (1994) Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study. Brain Res. 647, 1-9.
54. Van der Kooy D. and Hattori D. (1980) Dorsal raphe cells with collateral projections to the caudate-putamen and substantia nigra: a fluorescent retrograde double labeling study in the rat. Brain Res. 186, 1-7.
55. Wirtshafter D. and Cook D. F. (1998) Serotonin 1B agonists induce compartmentally organized striatal Fos expression in rats. Neuroreport 9, 1217-1221.
56. Xu M., Moratalla R., Gold L. H., Hiroi N., Koob G. F., Graybiel A. M., and Tonegawa S. (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79, 729-742.
57. Yadid G., Pacak K., Kopin I. J., and Goldstein D. S. (1994) Endogenous serotonin stimulates dopamine striatal release in conscious rats. J. Pharmacol. Exp. Ther. 270, 1158-1165.