5-hydroxytryptamine(1B) receptors modulate the effect of cocaine on c- fos expression: Converging evidence using 5-hydroxytryptamine(1B) knockout mice and the 5-hydroxytryptamine(1B/1D) antagonist GR127935

Molecular Pharmacology

Volumn 51, Issue 5, 1997, Pages 755-763

  Lucas, José J ^a   Segu, Louis ^a,b   Hen, René ^a,c  

^a Columbia University ^*  (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDINYL)1H INDOLE; 5-METHOXY 3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)1H INDOLE; INDOLE DERIVATIVE; OXADIAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SEROTONIN 1D RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DEPENDENCE; DRUG EFFECT; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; ANIMAL; CORPUS STRIATUM; GENETICS; METABOLISM; MOUSE MUTANT; ONCOGENE; PHYSIOLOGY;

ANIMALS; COCAINE; CORPUS STRIATUM; GENE EXPRESSION REGULATION; GENES, FOS; INDOLES; MICE; MICE, KNOCKOUT; OXADIAZOLES; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030609867     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.5.755     Document Type: Article

References (44)

1. Ritz, M. C., E. J. Cone, and M. J. Kuhar. Cocaine inhibition of ligand binding at dopamine, norepinephrine, and serotonin transporters: a structure-activity study. Life Sci. 46:635-645 (1990).
2. Koob, G. F. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13:177-184 (1992).
3. Gawin, F. H. Cocaine addiction: psychology and neurophysiology. Science (Washington D. C.) 251:1580-1586 (1991).
4. Loh, E. A., and D. C. S. Roberts. Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin. Psychopharmacology 101:262-266 (1990).
5. Cunningham, K. A., and P. M. Callahan. Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat. Psychopharmacology 104:177-180 (1991).
6. Peltier, R., and S. Schenk. The effects of serotonergic manipulations on cocaine self-administration in rats. Psychopharmacology 110:390-394 (1993).
7. Aronson, S. C., J. E. Black, C. J. McDougle, B. E. Scanley, P. Jatlow, T. R. Kosten, G. R. Heninger, and L. H Price. Serotonergic mechanisms of cocaine effects in humans. Psychopharmacology 119:179-185 (1995).
8. Satel, S. L., J. H. Krystal, P. L. Delgado, T. R. Kosten, and D. S. Charmey. Tryptophan depletion and attenuation of cue-induced craving for cocaine. Am. J. Psychiatry 152:778-783 (1995).
9. Guan, X.-M., and W. J. McBride. Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain Res. Bull. 23:541-547 (1989).
10. Benloucif, S. B., M. J. Keegan, and M. P. Galloway. Serotonin-facilitated dopamine release in vivo: pharmacological characterization. J. Pharmacol. Exp. Ther. 265:373-377 (1993).
11. Hartig, P. R., T. A. Branchek, and R. L. Weinshank. A subfamily of 5-HT1D receptor genes. Trends Pharmacol. Sci. 13:152-159 (1992).
12. Boschert, U., D. Aït Amara, L. Segu, and R. Hen. The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals. Neuroscience 58:167-182 (1993).
13. Hoyer, D., D. E. Clarke, J. R. Fozard, P. R. Hartig, G. R. Martin, E. J. Mylecharane, P. R. Saxena, and P. P. Humphrey. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:157-203 (1994).
14. B synaptic potential in rat dopamine neurons. J. Neurosci. 12:2000-2006 (1992).
15. Cameron, D. L., and J. T. Williams. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. J. Neurosci. 14:6733-6767 (1994).
16. Higgins, G. A., C. C. Jordan, and M. Skingle. Evidence that the unilateral activation of 5-HT1D receptors in the substantia nigra of the guinea-pig elicits contralateral rotation. Br. J. Pharmacol. 102:305-310 (1991).
17. Morgan, J. I., and T. Curran. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:421-451 (1991).
18. Graybiel, A. M., R. Moratalla, and H. A. Robertson. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl. Acad. Sci. USA 87:6912-6916 (1990).
19. Young, S. T., L. J. Porrino, and M. J. Iadarola. Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl. Acad. Sci. USA 88:1291-1295 (1991).
20. Self, D. W., and E. J. Nestler. Molecular mechanisms of drug reinforcement and addiction. Annu. Rev. Neurosci. 18:463-495 (1995).
21. Saudou, F., D. Aït Amara, M. LeMeur, S. Ramboz, L. Segu, M. Buhot, and R. Hen. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science (Washington D. C.) 265:1875-1878 (1994).
22. Crabbe, J., T. Phillips, D. Feller, R. Hen, C. Wenger, C. Lessov, and G. Schafer. Elevated alcohol consumption in null mutant mice lacking 5-HT1B receptors. Nat. Genet. 13:98-101 (1996).
23. Ramboz, S., F. Saudou, D. Aït Amara, C. Belzung, F. Misslin, L. Segu, M. Buhot, and R. Hen. 5-HT1B receptor knockout: physiological and behavioral consequences. Behav. Brain. Res. 73:305-312 (1996).
24. Slotnick, B. M., and C. M. Leonard. A Stereotaxic Atlas of the Albino Mouse Forebrain. U. S. Department of Health, Education, and Welfare, Rockville, MD (1975).
25. 1D binding sites. J. Neurochem. 58:951-959 (1992).
26. Couceyro, P., K. M. Pollock, K. Drews, and J. Douglass. Cocaine differentially regulates activator protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum. Mol. Pharmacol. 46:667-676 (1994).
27. Dragunow, M., G. S. Robertson, R. L. Faull, H. A. Robertson, and K. Jansen. D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience 37:287-294 (1990).
28. Iadarola, M. J., E. J. Chuang, C.-L. Yeung, Y. Hoo, M. Silverthorn, and G. Draisci. Induction and suppression of proto-oncogenes in the rat striatum after single or multiple treatments with cocaine or GBR-12909. NIDA Res. Monograph 125:181-211 (1993).
29. Torres, G., and C. Rivier. Cocaine-induced expression of striatal c-fos in the rat is inhibited by NMDA receptor antagonists. Brain Res. Bull. 30:173-176 (1993).
30. Skingle, M., D. I. C. Scopes, W. Feniuk, H. E. Connor, M. C. Carter, M. C. Clitherow, and M. B. Tyers. GR 127935: a potent and orally active 5-HT1D receptor antagonist. Br. J. Pharmacol. 110:9P (1993).
31. Pauwels, P. J., and C. Palmier. Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT 1Dalpha, 5-HT1Dbeta, 5-HT1A and opossum 5-HT1B receptors. Eur. J. Pharmacol. 290:95-103 (1995).
32. Starkey, S. J., and M. Skingle. 5-HT1D as well as 5-HT1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology 33:393-402 (1994).
33. 1B binding sites in the rat brain. Naunyn Schmiedebergs Arch. Pharmacol. 347:569-582 (1993).
34. Boulenguez, P., J. Abdelkefi, R. Pinard, A, Christolomme, and L. Segu. Effects of retinal deafferentation on serotonin receptor types in the superficial grey layer of the superior colliculus of the rat. J. Chem. Neuroanat. 6:167-175 (1993).
35. Kalivas, P. W., P. Duffy, and H. Eberhardt. Modulation of A10 dopamine neurons by γ-aminobutyric acid agonists. J. Pharmacol. Exp. Ther. 253: 858-866 (1990).
36. Konradi, C., J.-C. Leveque, and S. E. Hyman. Amphetamine and dopamine induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J. Neurosci. 16:4231-4239 (1996).
37. Chen, N. H., and M. E. Reith. Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships. J. Neurochem. 63:1701-1713 (1994).
38. Bhat, R. V., and J. M. Baraban. Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. J. Pharmacol. Exp. Ther. 267:496-505 (1993).
39. Robbins T. W., and B. J. Everitt. Function of dopamine in the dorsal and ventral striatum. Semin. Neurosci. 4:119-127 (1992).
40. Wise, R. A., and M. A. Bozarth. A psychomotor stimulant theory of addiction. Psychol. Rev. 94:469-492 (1987).
41. Castanon N., J. J. Lucas, K. Scearce, and R. Hen. The 5-HT1B/1D antagonist GR127935 decreases the effects of cocaine on c-fos expression and locomotion. Soc. Neurosci. Abstr. 25:361.11 (1996).
42. Parsons, L. H., F. Weiss, and G. F. Koob. Serotonin-1B receptor stimulation enhances dopamine-mediated reinforcement. Psychopharmacology 128:150-160 (1996).
43. Callahan, P. M., and K. A. Cunningham. Modulation of the discriminative stimulus properties of cocaine by 5-HT1B and 5-HT2C receptors. J. Pharmacol. Exp. Ther. 274:1414-1424 (1995).
44. Crabbe, J. C., J. K. Belknap, and K. J. Buck. Genetic animal models of alcohol and drug abuse. Science (Washington D. C.) 264:1715-1723 (1994).