A randomised, double-blind comparison of the efficacy and safety of citalopram compared to mianserin in elderly, depressed patients with or without mild to moderate dementia

International Journal of Geriatric Psychiatry

Volumn 15, Issue 4, 2000, Pages 295-305

  Karlsson, Ingvar ^a   Godderis, Jan ^b   De Mendonça Lima, Carlos Augusto ^c   Nygaard, Harald ^g   Simányi, Margarete ^d   Taal, Maarja ^e   Eglin, Mirjam ^f  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d Geriatriezentum am Wienerwald   (Austria)

^e Tallinn's Children Hospital   (Estonia)

^f H LUNDBECK A S   (Denmark)

^g NONE

Author keywords

Citalopram; Dementia; Depression; Elderly; Mianserin

Indexed keywords

CITALOPRAM; MIANSERIN; SEROTONIN UPTAKE INHIBITOR;

AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DEPRESSION; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; DRUG TOLERABILITY; EMOTIONAL STRESS; FATIGUE; FEMALE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL;

EID: 0034021991     PISSN: 08856230     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1166(200004)15:4<295::AID-GPS105>3.0.CO;2-C     Document Type: Article

References (49)

1. Ahlfors, U. G., Elovaara, S., Harma, P., Suoniemi, I., Heikkila, L., Nummi, K., Vartiainen, A., Vartiainen, H., Tamminen, T., Elgen, K. and Sundman, K. (1988) Clinical multicentre study of citalopram compared double-blindly with mianserin in depressed patients in Finland. Nord. Psykiatr. Tidsskr 42(3), 201-210.
2. Alexopoulos, G. S. (1991) Heterogeneity and comorbidity in dementia-depression syndromes. Int. J. Geriatr. Psychiat. 6, 125-127.
3. Alexopoulos, G. S., Young, R. C. and Meyers, B. S. (1993) Geriatric depression: age of onset and dementia. Biol. Psychiat. 34, 141-145.
4. Alexopoulos, G. S., Meyers, B. S., Young, R. C., Campbell, S., Silbersweig, D. and Charlson, M. (1997a) 'Vascular depression' hypothesis. Arch. Gen. Psychiat. 54, 915-922.
5. Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kakuma, T., Silbersweig, D. and Charlson, M. (1997b) Clinically defined vascular depression. Am. J. Psychiat. 154, 562-565.
6. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. revised (DSM-III-R). APA, Washington, DC.
7. Baldwin, R. C. (1993) Late life depression and structural brain changes: a review of recent magnetic resonance imaging research. Int. J. Geriatr. Psychiat. 8, 115-123.
8. Baldwin, D. and Johnson, F. N. (1995) Tolerability and safety of citalopram. Rev. Contemp. Pharmacother. 6. 315-325.
9. Blake, A. J., Mogan, K., Bendall, M. J., Dallosso, H., Ebrahim, S. B. J., Arie, T. H. D., Fentem, P. H. and Bassey, E. J. (1988) Falls by elderly people at home: prevalence and associated factors. Age Ageing 17(6), 365-372.
10. Blazer, D. (1989) Current concepts. Depression in the elderly. New Engl. J. Med. 320(3), 164-166.
11. Bonne, O., Shalev, A. Y. and Bloch, M. (1995) Delirium associated with mianserin. Eur. Neuropsychopharmacol. 5, 147-149.
12. Bradley, C. and Lewis, K. S. (1990) Measures of psychological well-being and treatment satisfaction developed from the response of people with tablet-treated diabetes. Diabetic Med. 7(5), 445-451.
13. Burgess, C. D., Turner, P. and Wadsworth, J. (1978) Cardiovascular response to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs. Br. J. Clin. Pharmacol. 5(Suppl. 1), 21S-28S.
14. Burrows, G. D., Davies, B., Hamer, A. and Vohra, J. (1979) Effect of mianserin on cardiac conduction. Med. J. Aust. 2, 97-98.
15. Fisch, R. Z. and Alexandrowitz, A. (1988) Delirium in a patient treated with mianserin. Br. Med. J. 296, 137.
16. Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975) 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J. Psychiat. Res. 12(3), 189-198.
17. Gottfries, C. G. (1990) Neurochemical aspects on aging and diseases with cognitive impairment. J. Neurosci. Res. 27(4), 541-547.
18. Gottfries, C. G. (1996) Scandinavian experience with citalopram in the elderly. Int. Clin. Psychopharmacol. 11(Suppl. 1), 41-44.
19. Gottfries, C. G., Bråne, G., Gullberg, B. and Steen, G. (1982) A new rating scale for dementia syndromes. Arch. Gerontol. Geriatr. 1, 311-330.
20. Hyttel, J., Arnt, J. and Sanchez, C. (1995) The pharmacology of citalopram. Rev. Contemp. Pharmacother. 6, 271-285.
21. ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use) (1998) Statistical Principals for Clinical Trials. ICH E9, Step 4.
22. Jones, B. N. and Reifler, B. V. (1994) Depression coexisting with dementia. Evaluation and treatment. Med. Clin. North Am. 78(4), 823-840.
23. Knegtering, H., Eijck, M. and Huijsman, A. (1994) Effects of antidepressants on cognitive functioning of elderly patients. Drugs Aging 5(3), 192-199.
24. Kopera, H. (1978) Anticholinergic and blood pressure effects of mianserin amitriptyline and placebo. Br. J. Clin. Pharmacol. 5(Suppl. 1), 29S-34S.
25. Koponen, H., Honkonen, S., Partanen, J. and Riekkinen, P. J. (1990) Epileptic attack, delirium, and a Creutzfeldt-Jakob-like syndrome during mianserin treatment. Neuropsychobiology 23, 164-168.
26. Kramer-Ginsberg, E., Greenwald, B. S., Krishnan, K. R., Christiansen, B., Hu, J., Ashtari, M., Patel, M. and Pollack, S. (1999) Neuropsychological functioning and MRI signal hyperintensities in geriatric depression. Am. J. Psvchiat. 156, 438-444.
27. Krishnan, K. R. and Gadde, K. M. (1996) The pathophysiological basis for late-life depression. Imaging studies of the aging brain. Am. J. Geriatr. Psychiat. 4(Supp. 1), S22-S33.
28. Kyle, C. J., Høpfner Petersen, H. F. and Overø, K. F. (1998) Comparison of the tolerability and efficacy of citalopram and amitriptyline in elderly depressed patients treated in general practice. Depression and Anxiety 8, 147-153.
29. La Pia, S., Giorgio, D., Ciriello, R., Sannino, A., De Simone, L., Paoletti, C. and Colonna, C. V. (1992) Evaluation of the efficacy, tolerability, and therapeutic profile of fluoxetine versus mianserin in the treatment of depressive disorders in the elderly. Current Therap. Res. 52, 847-858.
30. Lavergne, F., Berlin, I. and Ohie, J. P. (1996) Clinical differences in response to mianserin and fluvoxamine in depressive patients. Poster presented at 9th Annual Congress of the European Committee on Neuropsychopharmacology, Amsterdam, September 27.
31. Leonard, B. E. (1988) Pharmacological effects of serotonin reuptake inhibitors. J. Clin. Psychiat. 49(Suppl. 8), 12-17.
32. Montgomery, S. A. (1994) Clinically relevant effect sizes in depression. Eur. Neuropsychopharmacol. 4(3), 283-284.
33. Montgomery, S. A. and Åsberg, M. (1979) A new depression scale designed to be sensitive to change. Br. J. Psychiat. 134, 382-389.
34. Montgomery, S. A. and Johnson, F. N. (1995) Citalopram in the treatment of depression. Rev. Contemp. Pharmacother. 6, 297-306.
35. Montgomery, S. A., Rasmussen, J. G. C., Lyby, K., Connor, P. and Tanghoj, P. (1992) Dose response relationship of citalopram 20mg, citalopram 40mg and placebo in the treatment of moderate and severe depression. Int. Clin. Psychopharmacol. 6(Suppl. 5), 65-70.
36. Moon, C. A. L. and Jesinger, D. K. (1991) The effects of psychomotor performance of fluvoxamine versus mianserin in depressed patients in general practice. Br. J. Clin. Pract. 45(4), 259-262.
37. Muijen, M., Roy, D., Silverstone, T., Mehmet, A. and Christie, M. (1988) A comparative clinical trial of fluoxetine, mianserin and placebo in depressed out-patients. Acta Psychiatr. Scand. 78, 384-390.
38. Muldoon, C. (1996) The safety and tolerability of citalopram. Int. Clin. Psychopharmacol. 11(Suppl. 1), 35-40.
39. Nyth, A. L. and Gottfries, C. G. (1990) The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. A Nordic multicentre study. Br. J. Psychiat. 157, 894-901.
40. Nyth, A. L., Gottfries, C. G., Lyby, K., Smedegaard-Andersen, L., Gylding-Sabroe, J., Kristensen, M., Refsum, H.-E., Öfsti, E., Eriksson, S. and Syversen, S. A. (1992) A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia. Acta Psychiatr. Scand. 86, 138-145.
41. O'Brien, J., Ames, D., Chiu, E., Schweitzer, I., Desmond, P.-R. and Tress, B. (1998) Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study. Brit. Med. J. 317, 982-984.
42. Quitkin, F. M., Rabkin, J. G., Ross, D. and McGrath, P. J. (1984) Duration of antidepressant drug treatment. What is an adequate trial? Arch. Gen. Psvchiat. 41(3), 238-245.
43. Ragneskog, H., Eriksson, S., Karlsson, I. and Gottfries, C. G. (1996) Long-term treatment of elderly individuals with emotional disturbances: an open study with citalopram. Int. Pxychogeriatr. 84(4), 659-668.
44. Reynolds, C. F. III, Lebowitz, B. D. and Schneider, L. S. (1993) Diagnosis and treatment of depression in late life. The NIH consensus development conference on the diagnosis and treatment of depression in late life: an overview. Psychopharmacol. Bull. 29(1), 83-85.
45. Roberts, R. E., Kaplan, G. A., Shema, S. J. and Strawbridge, W. J. (1997) Does growing old increase the risk for depression? Am. J. Psychiat. 154, 1384-1390.
46. Schuirmann, D. J. (1987) A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. J. Pharmacokinet. Biopharm. 15, 657-680.
47. Steffens, D. C. and Krishnan, K. R. (1998) Structural neuroimaging and mood disorder: recent findings, implications for classification, and future directions. Biol. Psychiat. 43, 705-712.
48. de Wilde, J., Mertens, C., Fredericson, K. O. and Høpfner Petersen, H. E. (1985) Citalopram versus mianserin. A controlled, double-blind trial in depressed patients. Acta Psychiatr. Scand. 72, 89-96.
49. Williamson, G. M. and Schulz, R. (1995) Symptoms of depression in elderly persons: beyond the effects of physical illness and disability. Facts Res. Gerontology (Suppl.), 9-19.