Sane genetics for schizophrenia

Nature Medicine

Volumn 6, Issue 3, 2000, Pages 253-255

  Riley, Brien ^a   Williamson, Robert ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 15Q; CHROMOSOME 6P; GENE LOCATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SHORT SURVEY;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 9; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RISK FACTORS; SCHIZOPHRENIA;

EID: 0034021893     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/73085     Document Type: Short Survey

References (16)

1. Kendler, K.S. & Diehl, S.R. The genetics of schizophrenia: A current, genetic-epidemiologic perspective. Schizophr. Bull. 19, 261-285 (1993).
2. Risch, N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46, 222-228 (1990).
3. Gottesman, I. in Schizophrenia Genesis (W.H. Freeman, New York, 1991).
4. Riley, B.P. et al. A linkage study of the N-methyl-D-aspartate receptor subunit gene loci and schizophrenia in southern African Bantu-speaking families. Psychiatr. Genet. 7, 57-74 (1997).
5. Sherrington, R. et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164-167 (1988).
6. Pulver, A.E. et al. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. Neuropsychiatric Genet. 60, 252-260 (1995).
7. Riley, B.P. & McGuffin, P. Linkage and associated studies of schizophrenia. Sem. Med. Genet. (in press).
8. Freedman, R. et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. USA 94, 587-592 (1997).
9. Arolt, V. et al. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am. J. Med. Genet. Neuropsychiatric Genet. 67, 564-579 (1996).
10. Jakob, K. & Beckmann, H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural Transm. 65, 303-326 (1986).
11. Murphy, K.C., Jones, L.A. & Owen, M.J. High rates of schizophrenia in adults with velocardial-facial syndrome. Arch. Gen. Psychiatry 56, 940-945 (1999).
12. Bassett, A.S. & Chow, E.W.C. 22q11 deletion syndrome: A genetic subtype of schizophrenia. Biol. Psychiatry 46, 882-891 (1999).
13. Mohn, A.R., Gainetdinov, R.R., Caron, M.G. & Koller, B.H. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98, 427-436 (1999).
14. Kaufmann, C.A. et al. NIMM genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees. Am. J. Med. Genet. Neuropsychiatric Genet. 81, 282-289 (1998).
15. Riley, B.P. et al. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in southern African Bantu families. Am. J. Med. Genet. Neuropsychiatric Genet. (in press).
16. Cox, N.J. et al. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nature Genet. 21, 213-215 (1999).