Neural mediation of food aversions and anorexia induced by tumor necrosis factor and tumors

Neuroscience and Biobehavioral Reviews

Volumn 20, Issue 1, 1996, Pages 177-181

  Bernstein, Ilene L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Capsaicin; Cytokines area postrema; Learned food aversions; Tumor anorexia Cachexia; Vagus nerve

Indexed keywords

TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; AREA POSTREMA; AVERSIVE BEHAVIOR; BODY WEIGHT; CACHEXIA; CONFERENCE PAPER; CONTROLLED STUDY; FOOD INTAKE; FOOD PREFERENCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VAGOTOMY; ANIMAL; DRUG EFFECT; EATING; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ANOREXIA; EATING; RATS; TUMOR NECROSIS FACTOR-ALPHA; VAGOTOMY;

EID: 0029656263     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/0149-7634(95)00046-H     Document Type: Article

References (27)

1. Bernstein, I. L.; Courtney, L.; Braget, D. J. Estrogens and the Leydig LTW(m) tumor syndrome: anorexia and diet aversions attenuated by area postrema lesions. Physiol. Behav. 38:159-163; 1986.
2. Bernstein, I. L.; Goehler, L.E. Vagotomy produces learned food aversions in the rat. Behav. Neurosci. 97:585-594; 1983.
3. Bernstein, I. L.; R. A. Sigmundi. Tumor anorexia: A learned food aversion? Science 209:416418; 1980.
4. Bernstein, I. L.; Taylor, E. M.; Bentson, K.L. TNF-induced anorexia and learned food aversions are attenuated by area postrema lesions. Am. J. Physiol. 260:R906-R910; 1991.
5. Bernstein, I. L.; Treneer, C. M.; Goehler, L. E.; Murowchick, E. Tumor growth in rats: conditioned suppression of food intake and preference. Behav. Neurosci. 99:818-830; 1985.
6. Bernstein, I. L.; Treneer, C. M.; Kott, J. N. Area postrema mediates tumor effects on food intake, body weight, and learned aversions. Am. J. Physiol. 249:R296-R300; 1985.
7. Beutler, B.; Cerami, A. Cachectin: more than a tumor necrosis factor. New Engl. J. Med. 316:379-385; 1987.
8. Borison, H. L. Area postrema: chemoreceptor circumventricular organ of the medulla oblongata. Prog. Neurobiol. 32:351-390; 1989.
9. Darling, G.; Fraker, D. L.; Jensen, C.; Gorschboth, C. M.; Norton, J. A. Cachectic effects of recombinant human tumor necrosis factor in rats. Cancer Res. 50, 4008-4013; 1990.
10. Edwards, G. L.; Ritter; R. C. Ablation of the area postrema causes exaggerated consumption of preferred food in the rat. Brain Res. 216:265-276; 1981.
11. Garrattini, S.; Bizzi, A.; Donelli, M. G.; Guaitani, A.; Samanin, R.; Spreafico, F. Anorexia and cancer in animals and man. Cancer Treat. Rep. 7:115-140.
12. Mahony, S .M.; Beck, S. A.; Tisdale, M. J. Comparison of weight loss induced by recominant tumour necrosis factor with that produced by a cachexia-inducing tumour. Br. J. Cancer 57:385-389; 1988.
13. Martin, J. R.; Rogers, R. C.; Novin, D.; Van der Weele, D. A. Excessive gastric retention by vagotomized rats and rabbits given a solid diet. Bull. Psychconom. Soc. 10:291-294; 1977.
14. Moldawer, L. L.; Lowry, S. F.; Cerami, A. Cachectin: its impact on metabolism and nutritional status. A. Rev. Nutr. 8:585-609; 1988.
15. Mordes, J. P., Longscope, C.; Flatt, J. P. MacLean, D. B.; Rossini, A. A. The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. Endocrinology 115:167-173; 1984.
16. Mordes, J. P.; Rossini, A. A. Tumor-induced anorexia in the Wistar rat. Science 213:565-567; 1981.
17. Morrison, S. D. Control of food intake in cancer cachexia: a challenge and a tool. Physiol. Behav. 17:705-714; 1976.
18. Patton, J. S.; Peters, P. M.; McCabe, J.; Crase, J. D.; Hansen, S.; Chen, A. B.; Liggitt, D. Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents. J. Clin. Invest. 80:1587-1596; 1987.
19. Ritter, S.; McGlone. J. J.; Kelley, K. W. Absence of lithium-induced taste aversion after area postrema lesion. Brain Res. 201:501-506; 1980.
20. Ritter, S.; Dinh, T. T. Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat. J. Comp. Neurol. 271:79-90; 1988.
21. Ritter, R. C.; Ladenheim, E. E. Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin. Am. J. Physiol. 248:R501-R504; 1985.
22. Smith, B. K.; Kluger, M. J. AntiTNFantibodies normalized body temperature and enhanced food intake in tumor-bearing rats. Am. J. Physiol. 265:R615-619; 1993.
23. Socher, S. H.; Friedman, A.; Martinez, D. Recombinant human tumor necrosis factor induces acute reactions in food intake and body weight in mice. J. Exp. Med. 167:1957-1962; 1988.
24. South, E. H.; Ritter, R. C. Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety. Peptides 9:601-612; 1988.
25. Stovroff, M. C.; Fraker, D. L.; Swedenborg, J. A.; Norton, J. A. Cachectin/tumor necrosis factor: a possible mediator of cancer anorexia in the rat. Cancer Res. 48:4567-4572; 1988.
26. Wang, A., Creasy, A. A.; Ladner, M. B.; Lin, L. S.; Strickler, J.; Van Arsdell, J. N.; Yamamoto, R.; Mark, D. F. Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 228:149-154; 1985.
27. Watkins, L. R.: Maier, S. F.; Goehler, L. E. Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci., in press.