Synthesis of enantiopure 3,4-disubstituted piperidines. An asymmetric synthesis of (+)-paroxetme

Tetrahedron Asymmetry

Volumn 7, Issue 6, 1996, Pages 1591-1594

  Amat, Mercedes ^a   Hidalgo, José ^a   Bosch, Joan ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PAROXETINE; PIPERIDINE DERIVATIVE; SEROTONIN RECEPTOR;

ARTICLE; DECARBOXYLATION; DRUG SYNTHESIS; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; SEROTONIN UPTAKE;

EID: 0030009989     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/0957-4166(96)00189-9     Document Type: Article

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3. a) Christensen, J. A.; Squires, R. F., Ger. Patent 2,404,113, 1974; Chem. Abs. 1974, 81, 152011q.
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11. All yields are from material purified by column chromatography. Satisfactory analytical and/or spectral data were obtained for all new compounds.
12. Lactams 3 proved to be somewhat unstable, giving the corresponding 2-pyridones by opening of the oxazolidine ring.
13. 2).
14. 2).
15. 2).
16. 22 +31.4 (c 0.5, MeOH).
17. Saito, S.; Nakajima, H.; Inaba, M.; Moriwake, T. Tetrahedron Lett. 1989, 30, 837.
18. 2a 136-138°C (EtOH-ether)].