Inhibitory action of troglitazone, an insulin-sensitizing agent, on the calcium current in cardiac ventricular cells of guinea pig

Japanese Journal of Pharmacology

Volumn 82, Issue 2, 2000, Pages 102-109

  Katoh, Yoko ^a   Hashimoto, Shigeatsu ^a   Kimura, Junko ^a   Watanabe, Tsuyoshi ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Ca2+ channel; Cardiac myocyte; Diabetes; Patch clamp; Troglitazone

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; TROGLITAZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ANTAGONISM; DRUG INHIBITION; GUINEA PIG; HEART MUSCLE CELL; HEART PROTECTION; IC 50; MALE; NONHUMAN; PATCH CLAMP;

EID: 0034015780     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.82.102     Document Type: Article

References (30)

1. Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I and Horikoshi H: Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes 37, 1549-1558 (1988)
2. Suter SL, Nolan JJ, Wallace P, Gumbiner B and Olefsky JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15, 193-203 (1992)
3. Berger J, Bailey P, Biswas C, Cullinan CA, Doebber TW, Hayes NS, Saperstein R, Smith RG and Leibowitz MD: Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology 137, 4189-4195 (1996)
4. Yoshioka S, Nishino H, Shiraki T, Ikeda K, Koike H, Okuno A, Wada M, Fujiwara T and Horikoshi H: Antihypertensive effects of CS-045 treatment in obese Zucker rats. Metabolism 42, 75-80 (1993)
5. Lee MK, Miles PD, Khoursheed M, Gao KM, Moossa AR and Olefsky JM: Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 43, 1435-1439 (1994)
6. Ogihara T, Rakugi H, Ikegami H, Mikami H and Masuo K: Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens 8, 316-320 (1995)
7. Ren J, Dominguez LJ, Sowers JR and Davidoff AJ: Troglitazone attenuates high-glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes. Diabetes 45, 1822-1825 (1996)
8. Zhang F, Sowers JR, Ram JL, Standley PR and Peuler JD: Effects of pioglitazone on calcium channels in vascular smooth muscle. Hypertension 24, 170-175 (1994)
9. Yazawa K, Kaibara M, Ohara M and Kameyama M: An improved method for isolating cardiac myocytes useful for patch-clamp studies. Jpn J Physiol 40, 157-163 (1990)
10. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100 (1981)
11. 2+ currents and not endothelial nitric oxide production. Diabetes 46, 659-664 (1997)
12. Nakamura Y, Ohya Y, Onaka U, Fujii K, Abe I and Fujishima M: Inhibitory action of insulin-sensitizing agents on calcium channels in smooth muscle cells from resistance arteries of guinea-pig. Br J Pharmacol 123, 675-682 (1998)
13. Ikeda S and Watanabe T: Effects of troglitazone and pioglitazone on the action potentials and membrane currents of rabbit ventricular myocytes. Eur J Pharmacol 357, 243-250 (1998)
14. Kuriyama H, Kitamura K and Nabata H: Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev 47, 387-573 (1995)
15. Nakajima T, Iwasawa K, Oonuma H, Imuta H, Hazama H, Asano M, Morita T, Nakamura F, Suzuki J, Suzuki S, Kawakami Y, Omata M and Okuda Y: Troglitazone inhibits voltage-dependent calcium currents in guinea pig cardiac myocytes. Circulation 99, 2942-2950 (1999)
16. 2+ channel by stimulation of protein kinase C in isolated guinea pig ventricular cardiomyocytes. Gen Pharmacol 23, 1097-1102 (1992)
17. Bahr M, Spelleken M, Bock M, von Holtey M, Kiehn R and Eckel J: Acute and chronic effects of troglitazone (CS-045) on isolated rat ventricular cardiomyocytes. Diabetologia 39, 766-774 (1996)
18. 2+ channel current by phorbol esters. Am J Physiol 270, H620-H627 (1996)
19. Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y and Kadowaki T: Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101, 1354-1361 (1998)
20. Satoh H, Tsukamoto K, Hashimoto Y, Hashimoto N, Togo M, Hara M, Maekawa H, Isoo N, Kimura S and Watanabe T: Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. Biochem Biophys Res Commun 254, 757-763 (1999)
21. Buchanan TA, Meehan WP, Jeng YY, Yang D, Chan TM, Nadler JL, Scott S, Rude RK and Hsueh WA: Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. J Clin Invest 96, 354-360 (1995)
22. Shibata H, Nu S, Kobayashi M, Izumi T, Sasahara K and Yamaguchi K: Phase I study of a new hypoglycemic agent CS-045 in healthy volunteers - safety and phaemacokinetics in reported administration-. Rinsho Iyaku 9, 1519-1537 (1993) (in Japanese with English abstract)
23. 2+] and pH in rat skinned cardiac myocytes. Am J Physiol 269, H1656-H1663 (1995)
24. Rodrigues B and McNeill HJ: The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovasc Res 26, 913-922 (1992)
25. Schaffer SW: Cardiomyopathy associated with noninsulin-dependent diabetes. Mol Cell Biochem 107, 1-20 (1991)
26. Mahgoub MA and Abd-Elfattah AS: Diabetes mellitus and cardiac function. Mol Cell Biochem 180, 59-64 (1998)
27. Brown RA, Sundareson AM, Lee MM and Savage AO: Differential effects of chronic calcium channel blocker treatment on the inotropic response of diabetic rat myocardium to acute ethanol exposure. Life Sci 59, 835-847 (1996)
28. Afzal N, Ganguly KP, Dhalla K, Pierce NG, Singal KP and Dhalla SN: Beneficial effects of verapamil in diabetic cardiomyopathy. Diabetes 37, 936-942 (1988)
29. 2+ channels in beta-cell line. Diabetes 38, 188-193 (1989)
30. Masuda K, Okamoto Y, Tsuura Y, Kato S, Miura T, Tsuda K, Horikoshi H, Ishida H and Seino Y: Effects of troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia 38, 24-30 (1995)