Efficacy and safety of a novel beclomethasone dipropionate dry powder inhaler (Clickhaler®) for the treatment of adult asthma

Journal of Asthma

Volumn 37, Issue 2, 2000, Pages 183-190

  Stradling, J R ^a   Pearson, M G ^b   Morice, A H ^c   Peake, M D ^e   Barnes, N C ^d  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^c CASTLE HILL HOSPITAL   (United Kingdom)

^d LONDON CHEST HOSPITAL   (United Kingdom)

^e NONE

Author keywords

Beclomethasone dipropionate; Dry powder inhaler; Metered dose inhaler; Peak expiratory flow

Indexed keywords

BECLOMETASONE DIPROPIONATE;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; PEAK EXPIRATORY FLOW; RANDOMIZED CONTROLLED TRIAL;

EID: 0034012341     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.3109/02770900009055441     Document Type: Article

References (21)

1. Newman SP: Scintigraphic assessment of therapeutic aerosols. Crit Rev Ther Drug Carrier Syst 10:65 (1993).
2. Newman SP, Clark AR, Talaee N, Clarke SW: Pressurised aerosol deposition in the human lung with and without an "open" spacer. Thorax 44:706 (1989).
3. Brown PH, Blundell G, Greening AP, Crompton GK: Do large volume spacer devices reduce the systemic effects of high dose inhaled corticosteroids? Thorax 45:736 (1990).
4. Meeran K, Burrin JM, Noonan KA, Price CP, Ind PW: A large volume spacer significantly reduces the effect of inhaled steroids on bone formation. Postgrad Med J 71:156 (1995).
5. Bell J: International development of portable inhalers. J Invest Allergol Clin Immunol 7:417 (1997).
6. Ganderton D: General factors influencing drug delivery to the lung. Respir Med 91(Suppl A):13 (1997).
7. Morice AH, Peake MD, Allen MB, Campbell JH, Parry-Billings M: Reproducibility of bronchodilator response for a reservoir dry powder inhaler following routine clinical use. J Asthma 37:81 (2000).
8. O'Callaghan C, Everard ML, Ross Russell RI, Bush A, O'Keeffe P: Efficacy and safety of salbutamol delivered by a novel multidose dry powder inhaler (DPI) and a pressurized metered dose inhaler (MDI) in paediatric asthma. Eur Respir J 16(Suppl):126 (1997).
9. Newhouse MT, Nantel NP, Chambers C, Pratt B, Parry-Billings M: Clickhaler (a novel dry powder inhaler) provides similar bronchodilation to pressurized metered-dose inhaler, even at low flow rates. Chest 115:952 (1999).
10. Stradling JR, Pearson MG: Efficacy of beclomethasone dipropionate delivered via a novel dry powder inhaler (Clickhaler™). Am J Respir Crit Care Med 157: A639 (1998).
11. Kamada AK, Szefler SJ: How should inhaled glucocorticoids be compared? J Allergy Clin Immunol 99: 735 (1997).
12. Bootsma GP, Dekhuijzen PNR, Festen J, Mulder PGH, van Herwaarden CLA: Comparison of fluticasone propionate and beclomethasone diproprionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. Thorax 50:1044 (1995).
13. Kharitonov SA, Yates DH, Chung KF, Barnes PJ: Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J 9:196 (1996).
14. Venge P: Monitoring of asthma inflammation by serum measurements of eosinophil cationic protein (ECP). A new clinical approach to asthma management. Respir Med 89:1 (1995).
15. Pavord ID, Pizzichini MMM, Pizzichini E, Hargreave FE: The use of induced sputum to investigate airway inflammation. Thorax 52:498 (1997).
16. Barnes NC, Marone G, Di Maria GU, Visser S, Utama I, Payne SL: A comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. Eur Respir J 6:877 (1993).
17. Holliday SM, Faulds D, Sorkin EM: Inhaled fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma. Drugs 47:318 (1994).
18. Society of Pharmaceutical Medicine: Clinical development of drugs against asthma. J Pharm Med 3:193 (1993).
19. Morice AH, Stradling J, Barnes NC: Assessment of the acceptability of a new multidose dry powder inhaler in patients with asthma. Eur Respir J 16(Suppl): 126 (1997).
20. Allen MB, Ward MJ, Morice AH: Clickhaler™, a novel multidose dry powder inhaler has high acceptability in patients with asthma. Thorax 52(Suppl):105 (1997).
21. Adler LM, Clarke IC: Efficacy and safety of beclomethasone diproprionate (BDP) delivered via a novel dry powder inhaler (Clickhaler™) in paediatric patients with asthma. Thorax 52(Suppl):106 (1997).