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Volumn 11, Issue 2, 2000, Pages 135-140

N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1

Author keywords

Drug resistance; HIV; Reverse transcriptase; Thiourea

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HI 238; HI 243; HI 244; HI 255; HI 256; HI 275; RNA DIRECTED DNA POLYMERASE INHIBITOR; TROVIRDINE; UNCLASSIFIED DRUG;

EID: 0034012087     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020001100205     Document Type: Article
Times cited : (25)

References (16)
  • 1
    • 85038041645 scopus 로고    scopus 로고
    • San Diego: Molecular Simulation
    • Anonymous (1996) InsightII, computer program. San Diego: Molecular Simulation.
    • (1996) InsightII, Computer Program
  • 3
    • 0027027467 scopus 로고
    • LUDI: Rule-based automatic design of new substituents for enzyme inhibitor leads
    • Bohm HJ (1992) LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads. Journal of Computer-Aided Molecular Design 6:593-606.
    • (1992) Journal of Computer-Aided Molecular Design , vol.6 , pp. 593-606
    • Bohm, H.J.1
  • 4
    • 0028454828 scopus 로고
    • The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure
    • Bohm HJ (1994) The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure. Journal of Computer-Aided Molecular Design 8:243-256.
    • (1994) Journal of Computer-Aided Molecular Design , vol.8 , pp. 243-256
    • Bohm, H.J.1
  • 5
    • 0021107965 scopus 로고
    • Solvent-accessible surfaces of proteins and nucleic acids
    • Connolly ML (1983) Solvent-accessible surfaces of proteins and nucleic acids. Science 221:709-713.
    • (1983) Science , vol.221 , pp. 709-713
    • Connolly, M.L.1
  • 8
    • 0027486945 scopus 로고
    • Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro
    • Larder BA, Kellam P & Kemp SD (1993) Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro. Nature 365:451-453.
    • (1993) Nature , vol.365 , pp. 451-453
    • Larder, B.A.1    Kellam, P.2    Kemp, S.D.3
  • 9
    • 0033532653 scopus 로고    scopus 로고
    • Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus
    • Mao C, Sudbeck EA, Venkatachalam TK & Uckun FM (1999) Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus. Bioorganic and Medicinal Chemistry Letters 9:1593-1598.
    • (1999) Bioorganic and Medicinal Chemistry Letters , vol.9 , pp. 1593-1598
    • Mao, C.1    Sudbeck, E.A.2    Venkatachalam, T.K.3    Uckun, F.M.4
  • 10
    • 0032544145 scopus 로고    scopus 로고
    • Structure-based design of N-2-(1-piperidinylethyl)-N′-[2-(5-bromopyridyl)]-thiourea and N-2-(1-piperazinylethyl)-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
    • Mao C, Vig R, Venkatachalam TK, Sudbeck EA & Uckun FM (1998) Structure-based design of N-[2-(1-piperidinylethyl)-N′-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic and Medicinal Chemistry Letters 8:2213-2218.
    • (1998) Bioorganic and Medicinal Chemistry Letters , vol.8 , pp. 2213-2218
    • Mao, C.1    Vig, R.2    Venkatachalam, T.K.3    Sudbeck, E.A.4    Uckun, F.M.5
  • 13
    • 0031729622 scopus 로고    scopus 로고
    • Structure-based design of novel dihydroalkoxybenzyloxopyrimidine (DABO) derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase
    • Sudbeck EA, Mao C, Vig R, Venkarachalam TK, Tuel-Ahlgren L & Uckun FM (1998) Structure-based design of novel dihydroalkoxybenzyloxopyrimidine (DABO) derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Antimicrobial Agents and Chemotherapy 3225-3233.
    • (1998) Antimicrobial Agents and Chemotherapy , pp. 3225-3233
    • Sudbeck, E.A.1    Mao, C.2    Vig, R.3    Venkarachalam, T.K.4    Tuel-Ahlgren, L.5    Uckun, F.M.6
  • 15
    • 0031788490 scopus 로고    scopus 로고
    • Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase
    • Vig R, Mao C, Venkatachalam TK, Tuel-Ahlgren L, Sudbeck EA & Uckun FM (1998) Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Bioorganic and Medicinal Chemistry Letters 6:1789-1797.
    • (1998) Bioorganic and Medicinal Chemistry Letters , vol.6 , pp. 1789-1797
    • Vig, R.1    Mao, C.2    Venkatachalam, T.K.3    Tuel-Ahlgren, L.4    Sudbeck, E.A.5    Uckun, F.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.