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Volumn 91, Issue 1, 2000, Pages 52-58

Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: Results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2'-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity

Author keywords

DMAB; DNA adducts; Human prostate; Immunohistochemistry; PhIP

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2',3 DIMETHYL 4 BIPHENYLAMINE; ACYLTRANSFERASE; CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 1A2; DNA; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 0034011917     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00859.x     Document Type: Article
Times cited : (26)

References (30)
  • 1
    • 0023052281 scopus 로고
    • Studies on environmental chemical carcinogenesis in Japan
    • Sugimura, T. Studies on environmental chemical carcinogenesis in Japan. Science, 233, 312-318 (1986).
    • (1986) Science , vol.233 , pp. 312-318
    • Sugimura, T.1
  • 2
    • 0023735981 scopus 로고
    • Epidemiology and the prevention of cancer: Some recent developments
    • Doll, R. Epidemiology and the prevention of cancer: some recent developments. J. Cancer Res. Clin. Oncol., 114, 447-458 (1988).
    • (1988) J. Cancer Res. Clin. Oncol. , vol.114 , pp. 447-458
    • Doll, R.1
  • 3
    • 0023017251 scopus 로고
    • The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Felton, J. S., Knize, M. G., Shea, N. H., Lewis, P. R., Andersen, B. D., Happe, J. and Hatch, F. T. The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 7, 1081-1086 (1986).
    • (1986) Carcinogenesis , vol.7 , pp. 1081-1086
    • Felton, J.S.1    Knize, M.G.2    Shea, N.H.3    Lewis, P.R.4    Andersen, B.D.5    Happe, J.6    Hatch, F.T.7
  • 5
    • 0025986958 scopus 로고
    • Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP), in cigarette smoke condensate
    • Manabe, S., Tohyama, K., Wada, O. and Aramaki, T. Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP), in cigarette smoke condensate. Carcinogenesis, 12, 1945-1947 (1991).
    • (1991) Carcinogenesis , vol.12 , pp. 1945-1947
    • Manabe, S.1    Tohyama, K.2    Wada, O.3    Aramaki, T.4
  • 6
    • 0027215566 scopus 로고
    • Detection of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in beer and wine
    • Manabe, S., Suzuki, H., Wada, O. and Ueki, A. Detection of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in beer and wine. Carcinogenesis, 14, 899-901 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 899-901
    • Manabe, S.1    Suzuki, H.2    Wada, O.3    Ueki, A.4
  • 7
    • 0025768966 scopus 로고
    • A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S. and Sugimura, T. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12, 1503-1506 (1991).
    • (1991) Carcinogenesis , vol.12 , pp. 1503-1506
    • Ito, N.1    Hasegawa, R.2    Sano, M.3    Tamano, S.4    Esumi, H.5    Takayama, S.6    Sugimura, T.7
  • 10
    • 0343089923 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich, F. P. and Shimada, T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol., 4, 2946-2954 (1988).
    • (1988) Chem. Res. Toxicol. , vol.4 , pp. 2946-2954
    • Guengerich, F.P.1    Shimada, T.2
  • 11
    • 0001771998 scopus 로고
    • Xenobiotic metabolism
    • ed. L. G. Cockerham and B. S. Shane, CRC Press, Boca Raton, FL.
    • Hansen, L. G. and Shane, B. S. Xenobiotic metabolism. In "Basic Environmental Toxicology," ed. L. G. Cockerham and B. S. Shane, pp. 49-105 (1994). CRC Press, Boca Raton, FL.
    • (1994) Basic Environmental Toxicology , pp. 49-105
    • Hansen, L.G.1    Shane, B.S.2
  • 13
    • 0028069430 scopus 로고
    • CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans
    • Boobis, A. R., Lynch, A. M., Murray, S., de la Torre, R., Solans, A., Farre, M., Segura, J., Gooderham, N. J. and Davies, D. S. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer Res., 54, 89-94 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 89-94
    • Boobis, A.R.1    Lynch, A.M.2    Murray, S.3    De La Torre, R.4    Solans, A.5    Farre, M.6    Segura, J.7    Gooderham, N.J.8    Davies, D.S.9
  • 14
    • 0025013470 scopus 로고
    • Role of sulfation and acetylation in the activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA
    • Buonarati, M. H., Turteltanb, K. W., Shen, N. H. and Felton, J. S. Role of sulfation and acetylation in the activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA. Mutat. Res., 245, 185-190 (1990).
    • (1990) Mutat. Res. , vol.245 , pp. 185-190
    • Buonarati, M.H.1    Turteltanb, K.W.2    Shen, N.H.3    Felton, J.S.4
  • 15
    • 17044456908 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in paraffin-embedded sections and tissue distribution
    • Takahashi, S., Tamano, S., Hirose, M., Kimoto, N., Ikeda, Y., Sakakibara, M., Tada, M., Kadlubar, F. F., Ito, N. and Shirai, T. Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution. Cancer Res., 58, 4307-4313 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4307-4313
    • Takahashi, S.1    Tamano, S.2    Hirose, M.3    Kimoto, N.4    Ikeda, Y.5    Sakakibara, M.6    Tada, M.7    Kadlubar, F.F.8    Ito, N.9    Shirai, T.10
  • 16
    • 0031659021 scopus 로고    scopus 로고
    • Characteristics of nonneoplastic human prostate tissue transplanted into nude mice
    • Yamada, Y., Tozawa, K., Cui, L., Takahashi, S., Shirai, T. and Kohri, K. Characteristics of nonneoplastic human prostate tissue transplanted into nude mice. Prostate, 37, 109-115 (1998).
    • (1998) Prostate , vol.37 , pp. 109-115
    • Yamada, Y.1    Tozawa, K.2    Cui, L.3    Takahashi, S.4    Shirai, T.5    Kohri, K.6
  • 17
    • 17444448902 scopus 로고    scopus 로고
    • Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis
    • Shirai, T., Takahashi, S., Cui, L., Yamada, Y., Tada, M., Kadlubar, F. F. and Ito, N. Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis. Toxicol. Lett., 102-103, 441-446 (1998).
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 441-446
    • Shirai, T.1    Takahashi, S.2    Cui, L.3    Yamada, Y.4    Tada, M.5    Kadlubar, F.F.6    Ito, N.7
  • 18
    • 0024382140 scopus 로고
    • Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA
    • Tada, M., Aoki, H., Kojima, M., Morita, T., Shirai, T., Yamada, H. and Ito, N. Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA. Carcinogenesis, 10, 1397-1402 (1989).
    • (1989) Carcinogenesis , vol.10 , pp. 1397-1402
    • Tada, M.1    Aoki, H.2    Kojima, M.3    Morita, T.4    Shirai, T.5    Yamada, H.6    Ito, N.7
  • 19
    • 0024445437 scopus 로고
    • Human CYP1A2: Sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression
    • Ikeya, K., Jaiswal, A. K., Owens, R. A., Jones, J. E., Nebert, D.W. and Kimura, S. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol. Endocrinol., 3, 1399-1408 (1989).
    • (1989) Mol. Endocrinol. , vol.3 , pp. 1399-1408
    • Ikeya, K.1    Jaiswal, A.K.2    Owens, R.A.3    Jones, J.E.4    Nebert, D.W.5    Kimura, S.6
  • 20
    • 0025237412 scopus 로고
    • Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver
    • Ohsako, S. and Deguchi, T. Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver. J. Biol. Chem., 265, 4630-4634 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 4630-4634
    • Ohsako, S.1    Deguchi, T.2
  • 21
    • 0023723497 scopus 로고
    • Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene
    • Ercolani, L., Florence, B., Denaro, M. and Alexander, M. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. J. Biol. Chem., 263, 15335-15341 (1988).
    • (1988) J. Biol. Chem. , vol.263 , pp. 15335-15341
    • Ercolani, L.1    Florence, B.2    Denaro, M.3    Alexander, M.4
  • 23
    • 0025739669 scopus 로고
    • Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation
    • Ushiyama, H., Wakabayashi, K., Hirose, M., Itoh, H., Sugimura, T. and Nagao, M. Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation. Carcinogenesis, 12, 1417-1422 (1991).
    • (1991) Carcinogenesis , vol.12 , pp. 1417-1422
    • Ushiyama, H.1    Wakabayashi, K.2    Hirose, M.3    Itoh, H.4    Sugimura, T.5    Nagao, M.6
  • 24
    • 0030846542 scopus 로고    scopus 로고
    • Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: Relationship to cytochrome P4501A2 and N-acetyltransferase activity
    • Stillwell, W. G., Kidd, L. C. R., Wishnok, J. S., Tannenbaum, S. R. and Sinha, R. Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity. Cancer Res., 57, 3457-3464 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 3457-3464
    • Stillwell, W.G.1    Kidd, L.C.R.2    Wishnok, J.S.3    Tannenbaum, S.R.4    Sinha, R.5
  • 25
    • 0027207764 scopus 로고
    • Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP
    • Murray, B. P., Edwards, R. J., Murray, S., Singleton, A. M., Davies, D. S. and Boobis, A. R. Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. Carcinogenesis, 14, 585-592 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 585-592
    • Murray, B.P.1    Edwards, R.J.2    Murray, S.3    Singleton, A.M.4    Davies, D.S.5    Boobis, A.R.6
  • 26
    • 0028301237 scopus 로고
    • Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human liver microsomes
    • Zhao, K., Murray, S., Davies, D. S., Boobis, A. R. and Gooderham, N. J. Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human liver microsomes. Carcinogenesis, 15, 1285-1288 (1994).
    • (1994) Carcinogenesis , vol.15 , pp. 1285-1288
    • Zhao, K.1    Murray, S.2    Davies, D.S.3    Boobis, A.R.4    Gooderham, N.J.5
  • 28
    • 0026783540 scopus 로고
    • Identification of N-(deoxyguanosin-8-yl) -2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA
    • Lin, D., Kaderlik, K. R., Turesky, R. J., Miller, D. W., Lay, J. O. J. and Kadlubar, F. F. Identification of N-(deoxyguanosin-8-yl) -2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA. Chem. Res. Toxicol., 5, 691-697 (1992).
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 691-697
    • Lin, D.1    Kaderlik, K.R.2    Turesky, R.J.3    Miller, D.W.4    Lay, J.O.J.5    Kadlubar, F.F.6
  • 29
    • 0026469750 scopus 로고
    • Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine with 2′-deoxyguanosine and its phosphate esters
    • Nagaoka, H., Wakabayashi, K., Kim, S.-B., Kim, I.-S., Tanaka, Y., Ochiai, M., Tada, A., Nukaya, H., Sugimura, T. and Nagao, M. Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine with 2′-deoxyguanosine and its phosphate esters. Jpn. J. Cancer Res., 83, 1025-1029 (1992).
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 1025-1029
    • Nagaoka, H.1    Wakabayashi, K.2    Kim, S.-B.3    Kim, I.-S.4    Tanaka, Y.5    Ochiai, M.6    Tada, A.7    Nukaya, H.8    Sugimura, T.9    Nagao, M.10
  • 30
    • 0026536377 scopus 로고
    • Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse
    • Dooley, K. L., von Tungeln, L. S., Bucci, T., Fu, P. P. and Kadlubar, F. F. Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse. Cancer Lett., 62, 205-209 (1992).
    • (1992) Cancer Lett. , vol.62 , pp. 205-209
    • Dooley, K.L.1    Von Tungeln, L.S.2    Bucci, T.3    Fu, P.P.4    Kadlubar, F.F.5


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