A study of the iron and HFE status of blood donors, including a group who failed the initial screen for anaemia

British Journal of Haematology

Volumn 108, Issue 2, 2000, Pages 434-439

  Boulton, Frank ^a   Collis, David ^b   Inskip, Hazel ^b   Paes, Hazel ^a   Garlick, Matthew ^a  

^a NHS BLOOD AND TRANSPLANT   (United Kingdom)

^b Natl Blood Serv Southampton Ctr ^*

Author keywords

Frequency of blood donation; HFE; sTfR; TfR F index

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCREENING; TRANSFERRIN BLOOD LEVEL;

ANEMIA; BLOOD DONORS; BODY WEIGHT; DIET; FEMALE; FERRITINS; GENOTYPE; HEMOGLOBINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IRON; MALE; MEMBRANE PROTEINS;

EID: 0034011256     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01878.x     Document Type: Article

References (23)

1. Aisen, P. (1994) The transferrin receptor and the release of iron from transferrin. In: Progress in Iron Research (ed. by C. Hershko, A.M. Konijn, P. Aisen). Plenum Press, New York, NY, pp. 31-40.
2. Beguin, Y., Clemons, G.K., Pootrakul, P. & Fillet, G. (1993) Quantitative assessment of erythropoiesis and functional classification of anaemia based on measurements of serum transferrin receptor and erythropoietin. Blood, 81, 1067-1076.
3. Boulton, F.E. (1999) Threshold concentration of haemoglobin in donor blood (letter). Vox Sanguinis, 77, 108-109.
4. Boulton, F.E., Nightingale, M.N. & Reynolds, W. (1994) Improved strategy for screening prospective blood donors for anaemia. Transfusion Medicine, 4, 221-225.
5. Council of Europe (1999) Guide to the Preparation, Use and Quality Assurance of Blood Components, 5th edn. Council of Europe Publishing, Strasbourg.
6. Dagg, J.H., Goldberg, A. & Lochhead, A. (1966) Value of erythrocyte protoporphyrin in the diagnosis of latent iron deficiency (sideropenia). British Journal of Haematology, 12, 326-331.
7. Datz, C., Haas, T., Rinner, H., Sandhofer, F., Patsch, W. & Paulweber, B. (1998) Heterozygosity for the C282Y mutation in the hemochromatosis gene is associated with increased serum iron transferrin saturation and hemoglobin in young women: a protective role against iron deficiency? Clinical Chemistry, 44, 2429-2432.
8. Guttridge, M.G., Thompson, J., Worwood, M. & Darke, C. (1998) Rapid detection of genetic mutations associated with haemochromatosis. Vox Sanguinis, 75, 253-256.
9. Lee, G.R. (1998) Iron deficiency and iron-deficiency anemia. In: Wintrobe's Clinical Hematology, 10th edn (ed. by G.R. Lee, J. Foerster, J. Lukens, F. Paraskevas, J.P. Greer, G.M. Rodgers). Williams and Williams, Baltimore, MD, pp. 808-839.
10. Merryweather-Clarke, A.T., Worwood, M., Parkinson, L., Mattock, C., Pointon, J.J., Shearman, J.D. & Robson, K.H. (1998) The effect of HFE mutations on serum ferritin and transferrin saturation in the Jersey population. British Journal of Haematology, 101, 369-373.
11. Milman, N. & Kirchhoff, M. (1991) Influence of blood donation on iron stores assessed by serum ferritin and haemoglobin in a population survey of 1433 Danish males. European Journal of Haematology, 47, 134-139.
12. Milman, N. & Sondergaard, M. (1984) Iron stores in male blood donors evaluated by serum ferritin. Transfusion, 24, 464-468.
13. Mollison, P.L. (1979) Blood Transfusion in Clinical Medicine, 6th edn, pp. 4-5. Blackwell Scientific Publications, Oxford.
14. Newman, B. (1997) Very anemic donors may pass copper sulfate screening tests. Transfusion, 37, 670-671.
15. 4 anaemia screening. Transfusion Medicine, 9 (suppl. 1), 49.
16. Phillips, R.A., van Slyke, D.D., Hamilton, P.B., Dole, V.P., Emerson, K. & Archibald, R.M. (1950) Measurement of specific gravities of whole blood and plasma by standard copper sulfate solutions. Journal of Biological Chemistry, 183, 305-330.
17. Punnonen, K. & Rajamäki, A. (1999) Evaluation of iron status of Finnish blood donors using serum transferrin receptor. Transfusion Medicine, 9, 131-134.
18. Punnonen, K., Irjala, K. & Rajamäki, A. (1998) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood, 89, 1052-1057.
19. Rees, D.C., Williams, T.N., Maitland, K., Clegg, J.B. & Weatherall, D.J. (1998) Alpha thalassaemia is associated with increased soluble transferrin receptor levels. British Journal of Haematology, 103, 365-369.
20. Simon, T.L., Carry, P.J. & Cooper, E.M. (1981) Iron stores in blood donors. Journal of the American Medical Association, 245, 2038-2043.
21. Stata Corporation (1997) Stata Statistical Software: Release 5.0. Stata Corporation, College Station, TX.
22. Wagstaff, W. (Chairman of the Liaison Group of the UKBTS/NIBSC) (1996) Guidelines for the Blood Transfusion Services in the United Kingdom, 3rd edn. HMSO, London.
23. Worwood, M., Darke, C. & Trenchard, P. (1991) Hereditary haemochromatosis and blood donation (letter). British Medical Journal, 302, 593.