Subcutaneously administered prolactin and 20K hGH, but not rGH or 22K hGH, prevent restraint stress-induced gastric ulcers in rats

Endocrine Journal

Volumn 47, Issue SUPPL., 2000, Pages

  Fujikawa, Takahiko ^a   Fukuoka, Hidenori ^a   Alam, Khorshed S M ^a   Yoshizato, Hideo ^a   Higashimoto, Yoshifumi ^a   Soya, Hideaki ^b   Tanaka, Minoru ^a   Nakashima, Kunio ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

20K hGH; 22K hGH; PRL; Stress induced gastric ulcer; Subcutaneous administration

Indexed keywords

PROLACTIN;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFECT; IMMOBILIZATION STRESS; KIDNEY CAPSULE; NEUROMODULATION; NONHUMAN; RAT; STOMACH MUCOSA; STOMACH ULCER;

EID: 0034011143     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.47.supplmarch_s49     Document Type: Article

References (14)

1. McCarter J, Shaw MA, Winer LA, Baumann WG (1990) The 20,000 Da variant of human growth hormone does not bind to growth hormone receptors in human liver. Mol Cell Endocrinol 73: 11-14.
2. Smal J, Closset J, Hennen G, DeMeyts P (1985) Receptor-binding and down-regulatory properties of 22,000-Mr human growth hormone and its natural 20,000-Mr variant on IM-9 human lymphocytes. Biochem J 225: 283-289.
3. Hansen BS, Hjorth S, Welinder BS, Skeriver L, DeMeyts P (1993) The growth hormone (GH)-binding protein cloned from human IM-9 lymphocytes modulates the down-regulation of GH receptors by 22-and 20-kilodalton human GH in IM-9 lymphocytes and the biological effects of the hormone in Nb2 lymphoma cells. Endocrinology 133: 2809-2817.
4. Wada M, Uchida H, Ikeda M, Tsunekawa B, Naito N, Banba S, Tanaka E, Hishimoto Y, Honjo M (1998) The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formation with cell surface hGH receptor and hGH-binding protein circulating in human plasma. Mol Endocrinol 12: 146-156.
5. Yirmiya R, Shiavit Y, Ben-Eliyahu, Gale RP, Liebeskind Jc, Taylor AN, Weiner H (1991) Modulation of immunity and neoplasia by neuropeptides released by stressors. In: McCubbin JA, Kaufmann PG, Nemeroff CB, (eds) Stress, neuropeptides, and systemic disease, Academic Press, New York, pp. 261-286.
6. Kelly PA, Djiane J, Postel-Uiray M-C, Edery M (1991) The prolactin/growth hormone receptor family. Endocrine Rev 12: 235-251.
7. Bole-feysot C, Goffin V, Edery M, Binart N, Kelly PA (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocrine Rev 19: 225-268.
8. Dutt A, Kaplitt MG, Kow L-M, Pfaff DW (1994) Prolactin, central nervous system and behavior: a critical review. Neuroendocrinology 59: 413-419.
9. Thoman EB, Wetzel A, Levine S (1968) Lactation prevents disruption of temperature regulation and suppresses adrenocortical activity in rats. Commun Behav Biol 2: 165-171.
10. Drago F, Continella G, Conforto G, Scapagnini U (1985) Prolactin inhibits the development of stress-induced ulcers in the rats. Life Sci 36: 191-197.
11. Drago F, Montonero C (1997) Influence of growth hormone on cysteamine-induced gastro-duodenal lesions in rats: the involvement of somatostatin. Life Sci 61: 21-28.
12. Szabo S, Reichlin S, (1981) Somatostatin in rat tissues is depleted by cysteamine administration. Endocrinology 109: 2255-2257.
13. Fujikawa T, Soya H, Yoshizato H, Sakaguchi K, Doh-Ura K, Tanaka M, Nakashima K (1995) Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus. Endocrinology 136: 5608-5613.
14. Fujikawa T, Yamaguchi A, Morita I, Takeda H, Nishibe S (1996) Protective effects of Acanthopanax senticosus HARMS from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol Pharm Bull 19: 1227-1230.