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Volumn 7, Issue 1, 2000, Pages 64-74

Immunological and virological predictors of outcome during interferon-α therapy of chronic hepatitis C

Author keywords

Chronic hepatitis C; HCV RNA negativity at 2 days; Interferon; Lymphocyte subpopulation; Response to therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; CD11 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; RECOMBINANT ALPHA2A INTERFERON; VIRUS RNA;

EID: 0034010610     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2000.00193.x     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 0024368522 scopus 로고
    • Treatment of chronic hepatitis C with recombinant interferon alpha. A multicenter randomized, controlled trial
    • 1 Davis GL, Balart LA, Schiff ER et al. The Hepatitis International Therapy Group. Treatment of chronic hepatitis C with recombinant Interferon alpha. A multicenter randomized, controlled trial. N Engl J Med 1989; 321: 1501-1506.
    • (1989) N Engl J Med , vol.321 , pp. 1501-1506
    • Davis, G.L.1    Balart, L.A.2    Schiff, E.R.3
  • 2
    • 0024981607 scopus 로고
    • Recombinant interferon alfa therapy for chronic hepatitis C: A randomized, double-blind, placebo-controlled trial
    • 2 Bisceglie AM, Martin P, Kassianides C et al. Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N Engl J Med 1989; 321: 1506-1510.
    • (1989) N Engl J Med , vol.321 , pp. 1506-1510
    • Bisceglie, A.M.1    Martin, P.2    Kassianides, C.3
  • 3
    • 0027534328 scopus 로고
    • A randomized, controlled trial of weekly administration of lymphoblastoid interferon in patients with chronic hepatitis C
    • 3 Kawaga T, Morizane T, Saito H et al. A randomized, controlled trial of weekly administration of lymphoblastoid interferon in patients with chronic hepatitis C. J Hepatol 1993; 17: 91-96.
    • (1993) J Hepatol , vol.17 , pp. 91-96
    • Kawaga, T.1    Morizane, T.2    Saito, H.3
  • 4
    • 0031443554 scopus 로고    scopus 로고
    • Results of the multi-center natural interferon-& treatment for chronic hepatitis C: Correlation between total dose, administration periods and efficacy of therapy
    • 4 Saito H, Ebinuma H, Oda M, Ishii H. Results of the multi-center natural interferon-& treatment for chronic hepatitis C: correlation between total dose, administration periods and efficacy of therapy. Keio J Med 1997; 46: 177-183.
    • (1997) Keio J Med , vol.46 , pp. 177-183
    • Saito, H.1    Ebinuma, H.2    Oda, M.3    Ishii, H.4
  • 5
    • 7144227931 scopus 로고    scopus 로고
    • Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters
    • 5 Saito H, Ebinuma H, Takahashi M, Atsukawa K, Ohishi T, Ishii H. Short-course of interferon-β for the treatment of chronic hepatitis C: a multicenter trial for evaluating host immunological parameters. Int J Immunother 1998; 14: 115-128.
    • (1998) Int J Immunother , vol.14 , pp. 115-128
    • Saito, H.1    Ebinuma, H.2    Takahashi, M.3    Atsukawa, K.4    Ohishi, T.5    Ishii, H.6
  • 6
    • 0028204083 scopus 로고
    • Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection
    • 6 Tsubota A, Chayama K, Ikeda K et al. Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology 1994; 19: 1088-1094.
    • (1994) Hepatology , vol.19 , pp. 1088-1094
    • Tsubota, A.1    Chayama, K.2    Ikeda, K.3
  • 7
    • 9144257569 scopus 로고
    • Mutation in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • 7 Enomoto N, Sakuma I, Asahina Y et al. Mutation in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl Med 1995; 334: 77-81.
    • (1995) N Engl Med , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 8
    • 9044253702 scopus 로고    scopus 로고
    • Assessment of histological features and outcome of interferon therapy in chronic hepatitis C
    • 8 Kumagai N, Kuramochi S, Toda K et al. Assessment of histological features and outcome of interferon therapy in chronic hepatitis C. J Gastroenterol 1996; 31: 69-74.
    • (1996) J Gastroenterol , vol.31 , pp. 69-74
    • Kumagai, N.1    Kuramochi, S.2    Toda, K.3
  • 10
    • 0031783128 scopus 로고    scopus 로고
    • Hepatitic C virus infection: Virus/host interactions
    • 10 Pawlotsky J-M. Hepatitic C virus infection: virus/host interactions. J Viral Hep 1998; 5 (suppl): 3-8.
    • (1998) J Viral Hep , vol.5 , Issue.SUPPL. , pp. 3-8
    • Pawlotsky, J.-M.1
  • 11
    • 0029989024 scopus 로고    scopus 로고
    • Cloning of variable regions of an antibody that reacts with the soluble fraction of human liver cells and its possible value in chronic liver disease
    • 11 Saito H, Tada S, Ebinuma H et al. Cloning of variable regions of an antibody that reacts with the soluble fraction of human liver cells and its possible value in chronic liver disease. Hepatology 1996; 23: 1498-1506.
    • (1996) Hepatology , vol.23 , pp. 1498-1506
    • Saito, H.1    Tada, S.2    Ebinuma, H.3
  • 12
    • 0025912864 scopus 로고
    • Immunophenotyping of lymphocytes in liver tissue of patients with chronic liver diseases by flow cytometry
    • 12 Li X, Jeffers LJ. Reddy R et al. Immunophenotyping of lymphocytes in liver tissue of patients with chronic liver diseases by flow cytometry. Hepatology 1991; 14: 121-127.
    • (1991) Hepatology , vol.14 , pp. 121-127
    • Li, X.1    Jeffers, L.J.2    Reddy, R.3
  • 13
    • 6844258183 scopus 로고    scopus 로고
    • Phenotyping of intrahepatic and peripheral blood lymphocytes in patients with chronic hepatitis C
    • 13 Tran A, Yang G, Doglio A et al. Phenotyping of intrahepatic and peripheral blood lymphocytes in patients with chronic hepatitis C. Dig Dis Sci 1997; 42: 2495-2500.
    • (1997) Dig Dis Sci , vol.42 , pp. 2495-2500
    • Tran, A.1    Yang, G.2    Doglio, A.3
  • 14
    • 0031056420 scopus 로고    scopus 로고
    • Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity
    • 14 Khakoo SI, Soni PN, Savage KA et al. Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity. Am J Pathol 1997; 150: 963-970.
    • (1997) Am J Pathol , vol.150 , pp. 963-970
    • Khakoo, S.I.1    Soni, P.N.2    Savage, K.A.3
  • 15
    • 0026756333 scopus 로고
    • Peripheral blood lymphocyte subsets in patients with chronic hepatitis C - Effects of interferon treatment
    • 15 Wejstal R, Norkrans G, Lenkei R, Weiland O, Schvarcz R, Fryden A. Peripheral blood lymphocyte subsets in patients with chronic hepatitis C - effects of interferon treatment. Liver 1992; 12: 161-167.
    • (1992) Liver , vol.12 , pp. 161-167
    • Wejstal, R.1    Norkrans, G.2    Lenkei, R.3    Weiland, O.4    Schvarcz, R.5    Fryden, A.6
  • 16
    • 0026549851 scopus 로고
    • Lymphocyte subsets and β2-microglobulin expression in chronic hepatitis C/non-A, non-B. Effects of interferon-a treatment
    • 16 Wejstal R, Norkrans G, Weiland O et al. Lymphocyte subsets and β2-microglobulin expression in chronic hepatitis C/non-A, non-B. Effects of interferon-a treatment. Clin Exp Immunol 1992; 87: 340-345.
    • (1992) Clin Exp Immunol , vol.87 , pp. 340-345
    • Wejstal, R.1    Norkrans, G.2    Weiland, O.3
  • 17
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b: Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • 17 Enomoto N, Sakuma I, Asahina Y et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b: sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224-230.
    • (1995) J Clin Invest , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 18
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • 18 Gale MJ, Korth MJ, Tang NM et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997; 230: 217-227.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale, M.J.1    Korth, M.J.2    Tang, N.M.3
  • 19
    • 0025200429 scopus 로고
    • Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region
    • 19 Okamoto H, Okada S, Sugiyama YA et al. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region. Jpn J Exp Med 1990; 60: 215-222.
    • (1990) Jpn J Exp Med , vol.60 , pp. 215-222
    • Okamoto, H.1    Okada, S.2    Sugiyama, Y.A.3
  • 20
    • 0017785902 scopus 로고
    • Acute and chronic hepatitis revisited. Review by an international group
    • 20 Bianchi L, DeGroote J, Desmet VJ et al. Acute and chronic hepatitis revisited. Review by an international group. Lancet 1977; 2: 914-915.
    • (1977) Lancet , vol.2 , pp. 914-915
    • Bianchi, L.1    DeGroote, J.2    Desmet, V.J.3
  • 21
    • 0027167523 scopus 로고
    • Quantification of hepatitis C virus by competitive reverse transcription-polymerase chain reaction: Increase of the virus in advanced liver disease
    • 21 Kato N, Yokosuka O, Hosoda K et al. Quantification of hepatitis C virus by competitive reverse transcription-polymerase chain reaction: increase of the virus in advanced liver disease. Hepatology 1993; 18: 16-20.
    • (1993) Hepatology , vol.18 , pp. 16-20
    • Kato, N.1    Yokosuka, O.2    Hosoda, K.3
  • 22
    • 0028942769 scopus 로고
    • The role of autoimmunity in hepatitis C infection
    • 22 Meyer, zum Büchenfelde KH, Lohse AW et al. The role of autoimmunity in hepatitis C infection. J Hepatol 1995; 22 (suppl): 93-96.
    • (1995) J Hepatol , vol.22 , Issue.SUPPL. , pp. 93-96
    • Meyer1    Zum Büchenfelde, K.H.2    Lohse, A.W.3
  • 23
    • 0029117193 scopus 로고
    • Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection
    • 23 Iwata K, Wakita T, Okumura AA et al. Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection. Hepatology 1995; 22: 1057-1064.
    • (1995) Hepatology , vol.22 , pp. 1057-1064
    • Iwata, K.1    Wakita, T.2    Okumura, A.A.3
  • 24
    • 0028822075 scopus 로고
    • Significance of human leukocyte antigens DR3 and DR4 in chronic viral hepatitis
    • 24 Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Significance of human leukocyte antigens DR3 and DR4 in chronic viral hepatitis. Dig Dis Sci 1995; 40: 2098-2106.
    • (1995) Dig Dis Sci , vol.40 , pp. 2098-2106
    • Czaja, A.J.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 25
    • 0027682831 scopus 로고
    • Genetic predispositions for the immunological features of chronic active hepatitis
    • 25 Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Genetic predispositions for the immunological features of chronic active hepatitis. Hepatology 1993; 18: 816-822.
    • (1993) Hepatology , vol.18 , pp. 816-822
    • Czaja, A.J.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 26
    • 0029997811 scopus 로고    scopus 로고
    • Three new cytotoxic T cell epitopes identified within the hepatitis C virus nucleoprotein
    • 26 Kaneko T, Nakamura I, Kita H, Hiroishi K, Moriyama T, Imawari M. Three new cytotoxic T cell epitopes identified within the hepatitis C virus nucleoprotein. J Gen Virol 1996; 77: 1305-1309.
    • (1996) J Gen Virol , vol.77 , pp. 1305-1309
    • Kaneko, T.1    Nakamura, I.2    Kita, H.3    Hiroishi, K.4    Moriyama, T.5    Imawari, M.6
  • 27
    • 0028922525 scopus 로고
    • A helper T-cell antigen enhances generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro
    • 27 Kita H, Moriyama T, Kaneko T et al. A helper T-cell antigen enhances generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro. J Med Virol 1995; 45: 386-391.
    • (1995) J Med Virol , vol.45 , pp. 386-391
    • Kita, H.1    Moriyama, T.2    Kaneko, T.3
  • 28
    • 0028603391 scopus 로고
    • Hepatocellular expression of HLA-A, B, C molecules predicts primary response to interferon in patients with chronic hepatitis C
    • 28 Ballardini G, Groff P, Giostra F et al. Hepatocellular expression of HLA-A, B, C molecules predicts primary response to interferon in patients with chronic hepatitis C. Am J Clin Pathol 1994; 102: 746-751.
    • (1994) Am J Clin Pathol , vol.102 , pp. 746-751
    • Ballardini, G.1    Groff, P.2    Giostra, F.3
  • 29
    • 0027997775 scopus 로고
    • T cell recognition of hepatitis B and C viral antigens
    • 29 Jung M-C, Diepolder HM, Pare GR. T cell recognition of hepatitis B and C viral antigens. Eur J Clin Invest 1994; 24: 641-650.
    • (1994) Eur J Clin Invest , vol.24 , pp. 641-650
    • Jung, M.-C.1    Diepolder, H.M.2    Pare, G.R.3
  • 30
    • 0028962927 scopus 로고
    • Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
    • 30 Battegay M, Fikes J, Di Bisceglie AM et al. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol 1995; 69: 2462-2470.
    • (1995) J Virol , vol.69 , pp. 2462-2470
    • Battegay, M.1    Fikes, J.2    Di Bisceglie, A.M.3
  • 31
    • 0029078188 scopus 로고
    • HLA antigens in patients with chronic hepatitis C
    • 31 Vitte RL, Fortier C, Richardet JP et al. HLA antigens in patients with chronic hepatitis C. Tissue Antigens 1995; 45: 356-361.
    • (1995) Tissue Antigens , vol.45 , pp. 356-361
    • Vitte, R.L.1    Fortier, C.2    Richardet, J.P.3
  • 32
    • 0028832184 scopus 로고
    • HLA-class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus
    • 32 Koziel MJ, Dudley D, Afdhal N et al. HLA-class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. J Clin Invest 1995; 96: 2311-2321.
    • (1995) J Clin Invest , vol.96 , pp. 2311-2321
    • Koziel, M.J.1    Dudley, D.2    Afdhal, N.3
  • 33
    • 0028851607 scopus 로고
    • T-cell-mediated autologous hepatocytotoxicity in patients with chronic hepatitis C virus infection
    • 33 Liaw YF, Lee CS, Tsai SL, et al. T-cell-mediated autologous hepatocytotoxicity in patients with chronic hepatitis C virus infection. Hepatology 1995; 22: 1368-1373.
    • (1995) Hepatology , vol.22 , pp. 1368-1373
    • Liaw, Y.F.1    Lee, C.S.2    Tsai, S.L.3
  • 34
    • 0028968636 scopus 로고
    • Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant
    • 34 Weiner A, Erickson AL, Kansopon J et al. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci USA 1995; 92: 2755-2759.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2755-2759
    • Weiner, A.1    Erickson, A.L.2    Kansopon, J.3
  • 35
    • 0030969984 scopus 로고    scopus 로고
    • Possible association between HLA antigens and the response to interferon in Japanese patients with chronic hepatitis C
    • 35 Miyaguchi S, Saito H, Ebinuma H, Morizane T, Ishii H. Possible association between HLA antigens and the response to Interferon in Japanese patients with chronic hepatitis C. Tissue Antigens 1997; 49: 605-611.
    • (1997) Tissue Antigens , vol.49 , pp. 605-611
    • Miyaguchi, S.1    Saito, H.2    Ebinuma, H.3    Morizane, T.4    Ishii, H.5
  • 36
    • 0028915929 scopus 로고
    • Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A, B, C, and intercellular adhesion-1 molecules
    • 36 Ballardini G, Groff P, Pontisso P et al. Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A, B, C, and intercellular adhesion-1 molecules. J Clin Invest 1995; 95: 2067-2075.
    • (1995) J Clin Invest , vol.95 , pp. 2067-2075
    • Ballardini, G.1    Groff, P.2    Pontisso, P.3
  • 37
    • 0028152884 scopus 로고
    • Expression of cytokine-dependent immune adhesion molecules by hepatocytes and bile duct cells in chronic hepatitis C
    • 37 Mosnier JF, Scoazec JY, Marcellin P, Degott C, Benhamou JP, Feldmann G. Expression of cytokine-dependent immune adhesion molecules by hepatocytes and bile duct cells in chronic hepatitis C. Gastroenterology 1994; 107: 1457-1468.
    • (1994) Gastroenterology , vol.107 , pp. 1457-1468
    • Mosnier, J.F.1    Scoazec, J.Y.2    Marcellin, P.3    Degott, C.4    Benhamou, J.P.5    Feldmann, G.6
  • 38
    • 0028931665 scopus 로고
    • Serum intercellular adhesion molecule-1 levels in chronic hepatitis C: Association with disease activity and response to interferon α
    • 38 Nouri-Aria KT, Koskinas J, Tibbs CJ, Portmann BC, Williams R. Serum intercellular adhesion molecule-1 levels in chronic hepatitis C: association with disease activity and response to Interferon α. Gut 1995; 36: 599-603.
    • (1995) Gut , vol.36 , pp. 599-603
    • Nouri-Aria, K.T.1    Koskinas, J.2    Tibbs, C.J.3    Portmann, B.C.4    Williams, R.5
  • 39
    • 0032033669 scopus 로고    scopus 로고
    • High level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C
    • 39 Saito H, Ebinuma H, Tsuchimoto K et al. High level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C. Hepatol Res 1998; 10: 225-236.
    • (1998) Hepatol Res , vol.10 , pp. 225-236
    • Saito, H.1    Ebinuma, H.2    Tsuchimoto, K.3
  • 40
    • 0029151317 scopus 로고
    • Behavior of soluble HLA class I antigens in patients with chronic hepatitis C during interferon therapy: And early predictor marker of response?
    • 40 Puppo F, Piccioto A, Brenci S et al. Behavior of soluble HLA class I antigens in patients with chronic hepatitis C during interferon therapy: and early predictor marker of response? J Clin Immunol 1995; 15: 179-184.
    • (1995) J Clin Immunol , vol.15 , pp. 179-184
    • Puppo, F.1    Piccioto, A.2    Brenci, S.3
  • 41
    • 0031772069 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 gene abnormality and loss of growth inhibitory effect on interferon-α in human hepatoma cell lines
    • 41 Tada S, Saito H, Tsunematsu S et al. Interferon regulatory factor-1 gene abnormality and loss of growth inhibitory effect on interferon-α in human hepatoma cell lines. Int J Oncol 1998; 13: 1207-1216.
    • (1998) Int J Oncol , vol.13 , pp. 1207-1216
    • Tada, S.1    Saito, H.2    Tsunematsu, S.3
  • 42
    • 0029977260 scopus 로고    scopus 로고
    • Serum levels of hepatitis C virus core protein in patients with chronic hepatitis C treated with interferon alfa
    • 42 Tanaka E, Kiyosawa K, Matsumoto A et al. Serum levels of hepatitis C virus core protein in patients with chronic hepatitis C treated with interferon alfa. Hepatology 1996; 23: 1330-1333.
    • (1996) Hepatology , vol.23 , pp. 1330-1333
    • Tanaka, E.1    Kiyosawa, K.2    Matsumoto, A.3
  • 43
    • 0028607433 scopus 로고
    • Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon
    • 43 Saitoh H, Naitoh S, Okamoto H, Akahane Y. Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon. J Interferon Res 1994; 14: 2 39-244.
    • (1994) J Interferon Res , vol.14 , pp. 239-244
    • Saitoh, H.1    Naitoh, S.2    Okamoto, H.3    Akahane, Y.4


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