The route of administration of an immunodominant peptide derived from heat-shock protein 65 dramatically affects disease outcome in pristane-induced arthritis

Immunology

Volumn 99, Issue 3, 2000, Pages 338-344

  Francis, J N ^c   Lamont, A G ^a   Thompson, S J ^b  

^a Peptide Therapeutics Ltd   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; PRISTANE; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BACTERIAL PROTEINS; CELL DIVISION; CELLS, CULTURED; CHAPERONINS; CYTOKINES; DISEASE PROGRESSION; EPITOPES; IMMUNOSUPPRESSIVE AGENTS; IMMUNOTHERAPY; INJECTIONS, INTRAPERITONEAL; INSTILLATION, DRUG; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED CBA; T-LYMPHOCYTES; TERPENES;

EID: 0034010390     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00969.x     Document Type: Article

References (39)

1. 1. Liu G.Y. & Wraith D.C. (1995) Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice - implications for autoimmunity. Int Immunol 7, 1255.
2. 2. Myers L.K., Terato K., Seyer J.M., Stuart J.M. & Kang A.H. (1992) Characterisation of a tolerogenic T cell epitope of type II collagen and its relevance to collagen-induced arthritis. J Immunol 149, 1439.
3. 3. Anderton S.M., Van Der Zee R., Noordzij A. & Van Eden W. (1994) Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J Immunol 152, 3656.
4. 4. Van Eden W., Thole J.E.R., Van Der Zee R. et al (1988) Cloning the mycobacterial epitope recognised by T lymphocytes in adjuvant arthritis. Nature 331, 171.
5. 5. Elias D., Reshef T., Birk O.S., Van Der Zee R., Walker M.D. & Cohen I.R. (1991) Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 88, 3088.
6. 6. Trentham D.E. (1985) The immunopathogenesis of rheumatoid arthritis. J Rheumatol 12, 7.
7. 7. Staines N.A., Harper N., Ward F.J., Mamstrom V., Holmdahl R. & Bansal S. (1996) Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin Exp Immunol 103, 368.
8. 8. Prakken B.J., Van Der Zek R., Anderton S.M., Van Kooten P.J.S., Kuis W. & Van Eden W. (1997) Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T-cell epitope in rats suppresses both adjuvant arthritis and non-microbially induced experimental arthritis. Proc Natl Acad Sci USA 94, 3284.
9. 9. Metzler B. & Wraith D.C. (1993) Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity. Int Immunol 5, 1159.
10. 10. Daniel D. & Wegmann D.R. (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9). Proc Natl Acad Sci USA 93, 956.
11. 11. Hopkins S.J., Freemont A.J. & Jayson M.I.V. (1984) Pristane-induced arthritis in BALB/C mice. I. Clinical and histological features of arthropathy. Rheumatol Int 5, 21.
12. 12. Bedwell A.E., Elson C.J. & Hinton C.E. (1987) Immunological involvement in the pathogenesis of pristane-induced arthritis. Scand J Immunol 25, 393.
13. 13. Wooley P.H., Seibold J.R., Whalen J.D. & Chapdelaine J.M. (1989) Pristane-induced arthritis the immunological and genetic features of an experimental murine model of autoimmune-disease. Arthritis Rheum 32, 1022.
14. 14. Stasiuk L.M., Ghoraishian M., Elson C.J. & Thompson S.J. (1997) Pristane-induced arthritis is CD4+ T-cell dependent. Immunology 90, 81.
15. 15. Levitt N.G., Fernando-Madrid F. & Wooley P.H. (1992) Pristane induced arthritis in mice. IV. Immunotherapy with monoclonal antibodies directed against lymphocyte subsets. J Rheumatol 19, 1342.
16. 16. Thompson S.J., Rook G.A.W., Brealey R.J., Van Der Zee R. & Elson C.J. (1990) Autoimmune reactions to heat-shock proteins in pristane-induced arthritis. Eur J Immunol 20, 2479.
17. 17. Thompson S.J., Hitsumoto Y., Ghoraishian M., Van Der Zee R. & Elson C.J. (1991) Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp65 protected DBA/1 mice. Autoimmunity 11, 89.
18. 18. Barker R.N., Webb G.R., Thompson S.J., Ghoraishian M., Ponsford F.M. & Elson C.J. (1992) Differential effects of immunisation with mycobacterial 65 kD heat shock protein on two models of autoimmunity. Autoimmunity 14, 73.
19. 19. Beech J.T., Siew L.K., Ghoraishian M., Stasiuk L.M., Elson C.J. & Thompson S.J. (1997) CD4 (+) Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis. J Immunol 159, 3692.
20. 20. Thompson S.J., Francis J.N., Siew L.K. et al. (1998) An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis. J Immunol 160, 4628.
21. 21. Beech J.T., Bainbridge T. & Thompson S.J. (1997) Incorporation of cells into an ELISA system enhances antigen-driven lymphokine detection. J Immunol Methods 205, 163.
22. 22. Zhao Y.X., Abdelnour A., Holmdahl R. & Tarkowski A. (1995) Mice with the Xid B cell defect are less susceptible to developing Staphylococcus aureus-induced arthritis. J Immunol 155, 2067.
23. 23. Hoyne G.F., O'Hehir R.E., Wraith D.C., Thomas W.R. & Lamb J.R. (1993) Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med 178, 1783.
24. 24. Openshaw P., Murphy E.E., Hosken N.A. et al. (1995) Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 182, 1357.
25. 25. Loewi G., Holborow J. & Temple A. (1966) Inhibition of delayed hypersensitivity by pre-immunisation without complete adjuvant. Immunology 10, 339.
26. 26. Muir A., Peck A., Clare-Salzler M., Song Y.H. et al. (1995) Insulin immunisation of nonobese diabetic mice induces a protective insulitis characterised by diminished intra-islet interferon-gamma transcription. J Clin Invest 95, 628.
27. 27. Racke M.K., Bonomo A., Scott D.E. et al. (1994) Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 180, 1961.
28. 28. Saoudi A., Simmonds S., Huitinga I. & Mason D. (1995) Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: Evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells. J Exp Med 182, 335.
29. 29. Saoudi A., Kulun J., Huygen K. et al. (1993) Th2 activated cells prevent experimental autoimmune uveoretinitis, a Th1-dependent autoimmune disease. Eur J Immunol 23, 3096.
30. 30. Tian J., Atkinson M.A., Claresalzler M. et al. (1996) Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183, 1561.
31. 31. Anderton S.M. & Wraith D.C. (1998) Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur J Immunol 28, 1251.
32. 32. Hoyne G.F., Askonas B.A., Hetzel C., Thomas W.R. & Lamb J.R. (1996) Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int Immunol 8, 335.
33. 33. Zhang X., Brunner T., Carter L. et al. (1997) Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med 185, 1837.
34. 34. Phillips-Quagliata J.M. & Lamm M.E. (1988) Migration of lymphocytes in the mucosal immune system. In: Migration and Homing of Lymphoid Cells (ed. A.J. HUSBAND) p. 53. CRC Press Inc., Boca Raton, FL.
35. 35. Quiding-Jarbrink M., Nordstrom I., Granstrom G. et al. (1997) Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations a molecular basis for the compartmentalization of effector B cell responses. J Clin Invest 99, 1281.
36. 36. Salmi M., Andrew D.P., Butcher E.C. & Jalkanen S. (1995) Dual binding of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms. J Exp Med 181, 137.
37. 37. Barker R.N., Wells A.D., Ghoraishian M. et al. (1996) Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis. Clin Exp Immunol 103, 83.
38. 38. Elson C.J., Barker R.N., Thompson S.J. & Williams N.A. (1995) Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 16, 71.
39. 39. Siew L.K., Beech J.T., Thompson S.J. & Elson C.J. (1998) Effect of T-helper cytokine environment on specificity of T-cell responses to mycobacterial 65000 MW heat shock protein. Immunology 93, 493.