Radionuclide analysis of drug-induced blood-pool changes in liver and other organs

Journal of Nuclear Medicine

Volumn 41, Issue 3, 2000, Pages 474-479

  Bhargava, Kuldeep K ^a   Palestro, Christopher J ^a,b   Camaya, Maria V ^a   Rajvanshi, Pankaj ^a   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

99mTc; Drug; Liver; Microsphere; Vascular

Indexed keywords

ERYTHROCYTE TC 99M; GLYCERYL TRINITRATE; LABETALOL; PHENTOLAMINE MESYLATE; PHENYLEPHRINE; RADIOISOTOPE;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; ERYTHROCYTE; ISOTOPE LABELING; LIVER BLOOD FLOW; MALE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; RAT; SPLEEN BLOOD FLOW;

ANIMALS; ERYTHROCYTES; LIVER; LIVER CIRCULATION; MALE; MICROSPHERES; RADIOISOTOPES; RATS; RATS, INBRED F344; TECHNETIUM; VASODILATOR AGENTS;

EID: 0034009914     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Gupta S, Irani AN, Gorla GR. Hepatocyte transplantation: emerging insights into mechanisms of liver repopulation and their relevance to potential therapies. J Hepatol. 1999;30:162-170.
2. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatalogy. 1996;23:482-496.
3. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science, 1994;263:1149-1152.
4. Overturf K, Al-Dhalimy M, Ou C-N, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol. 1997;151:1273-1280.
5. Laconi E, Oren R, Mukhopadhyay DK, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol. 1998;153:319-329.
6. Xu X, Schwab AJ, Barker F III, Goresky CA, Pang KS. Salicylamide sulfate cell entry in perfused rat liver: a multiple-indicator dilution study. Hepatology. 1994;19:229-244.
7. Gupta S, Rajvanshi P, Sokhi RP, et al. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology. 1999;29:509-519.
8. Gupta S, Vemuru RP, Lee C-D, Yerneni P, Aragona E, Burk RD. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Hum Gene Ther. 1994;5:959-967.
9. Pannen BH, Bauer M. Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats. Life Sci. 1998;62:2025-2033.
10. Iwai M, Shimazu T. Exaggeration of acute liver damage by hepatic sympathetic nerves and circulating catecholamines in perfused liver of rats treated with D-galactosamine. Hepatology. 1996;23:524-529.
11. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1985.
12. Robertson RE, Robertson D. Drugs used for the treatment of myocardial ischemia. In: Hardman JG, Limbird, LE, eds. Goodman and Gilman's: The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill 1996:759-779.
13. Hashimoto K, Hashimoto T, Iizuka H, Tsukada T, Matsuda H, Imai S. Hypotensive and vascular effects of labetalol in the normotensive rat and dog. Jpn Heart J. 1978;19:762-774.
14. Albillos A, Lledo JL, Banares R, et al. Hemodynamic effects of alpha-adrenergic blockade with prazosin in cirrhotic patients with portal hypertension. Hepatology. 1994;20:611-617.
15. Bolognesi M, Sacerdoti D, Merkel C, Bombonato G, Enzo E, Gatta A. Effects of chronic therapy with nadolol on portal hemodynamics and on splanchnic impedance indices using Doppler sonography: comparison between acute and chronic effects. J Hepatol. 1997;26:305-311.
16. Grech P, Dave S, Cunningham DA, Witherow RO. Combined papaverine test and radionuclide penile blood flow in impotence: method and preliminary results. Br J Urol. 1992;69:408-417.
17. Siraj QH, Hilson AJ. Diagnostic value of radionuclide phallography with intravenous vasodilator stress in the evaluation of arteriogenic impotence. Eur J Nucl Med. 1994;21:651-657.
18. Watanabe Y, Puschel P, Gardemann A, Jungermann K. Presinusoidal and proximal intrasinusoidal confluence of hepatic artery and portal vein in rat liver: functional evidence by orthotopic and retrograde bivascular perfusion. Hepatology. 1994;19: 1198-1207.