Calcium crystal effects on the cells of the joint: Implications for pathogenesis of disease

Current Opinion in Rheumatology

Volumn 12, Issue 3, 2000, Pages 223-227

  Cheung, Herman S ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Department of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COLLAGENASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTHROPATHY; CALCIUM TRANSPORT; CELL ACTIVATION; ENDOCYTOSIS; ENZYME ACTIVATION; HUMAN; MITOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

CALCIUM PHOSPHATES; CALCIUM PYROPHOSPHATE; CHONDROCALCINOSIS; COLLAGENASES; CRYSTALLIZATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; JOINTS; MATRIX METALLOPROTEINASE 13; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0034009897     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200005000-00012     Document Type: Review

References (32)

1. 1 Zitnan D, Sitaz S: Natural course of articular chondrocalcinosis. Arthritis Rheum 1976;19:363-390.
2. 2 Ryan LM, Cheung HS: Role of crystals in osteoarthritis. In Rheumatic diseases of America. Edited by Brandt, KD. Philadelphia: W.B. Saunders;1999:257-267.
3. 3 Ryan LM, McCarty DJ: Calcium pyrophosphate dihydrate crystal deposition disease, pseudogout, and articular chondrocalcinosis. In Arthritis and allied conditions. Edited by Koopman WJ. Baltimore: Williams and Wilkins;1997:2103-2126.
4. 4 Halverson PB, McCarty DJ: BCP [apatite, octacalcium phosphate, tricalcium phosphate] crystal deposition disease. In Arthritis and allied condilions. Edited by Koopman WJ. Baltimore, MD: Williams and Wilkins;1997:2127-2142.
5. 5 Halverson PB, Cheung HS, McCarty DJ, et al.: The "Milwaukee shoulder": association of microspheroids containing hydroxyapatite crystals, active collagenase and neutral protease with rotator cuff defects. II. Synovial fluid studies. Arthritis Rheum 1981, 24:474-483.
6. 6 McCarty DJ, Halverson PB, Carrera GF, et al.: "Milwaukee shoulder": association of microspheroids containing HA crystals, activate collagenase and neutral protease with rotator cuff defects. I. Clinical aspects. Arthritis Rheum 1981, 24:464-473.
7. 7 Cheung HS, Ryan LM: Role of crystal deposition in matrix degradation. In Joint cartilage degradation: basic and clinical aspects. Edited by Woessner FJ, Howell DS. New York: Marcel Dekker;1993:209-223.
8. 8 Rothenberg RJ, Cheung H: Rabbit synoviocyte inositol phospholipid metabolism is stimulated by hydroxyapatitite crystals. Am J Physiol 1988, 254:C554-C559.
9. 9 Cheung HS, Sallis JD, Struve JA: Specific inhibition of BCP and CPPD crystal-induced collagenase and stromelysin synthesis by phosphocitrate. Biochem Biophys Acta 1996;1315:105-111.
10. 10 McCarthy GM, Mitchell PG, Struve JA, Cheung HS: Basic calcium phosphate crystal cause coordinate induction and secretion of collagenase and stromelysin. J Cell Physiol 1992, 153:140-146.
11. 11 McCarthy GM, Augustine JA, Balwin AS, et al.: Molecular mechanism of BCP crystal-induced activation of human fibroblasts: role of nuclear factor κβ, activator protein 1 and protein kinase C. J Biol Chem 1998, 273:35161-35169. Basic calcium phosphate crystal-induced cell activation is associated with NFκβ and AP-1 induction, and protein kinase C activation in fibroblasts.
12. 12 Bai G, Howell DS, Roos BA, et al.: Basic calcium phosphate crystals upregulate metalloproteinases and downregulate tissue inhibitor of metalloproteinase in human fibroblasts. Bone 1998, 23:SA125.
13. 13 Cheung H, Mitchell P, Pledger WJ: Activation of proto-oncogenes by BCP crystals: Effect of beta-interferon. Cancer Res 1989, 49:134-138.
14. 14 Mitchell PG, Pledger WJ, Cheung HS: Molecular mechanisms of basic calcium phosphate crystal-induced mitogenesis, role of protein kinase C. J Biol Chem 1989, 264:14071-14077.
15. 15 Howard JE: Studies on urinary stone formation: a saga of clinical investigation. Johns Hopkins Med J 1976, 139:239-252.
16. 16 Tew WP, Malis CD, Howard JE, Lehninger AL: Phosphocitrate inhibits mitochondrial and cytosolic accumulation of calcium in kidney cells in vivo. Proc Natl Acad Sci USA 1981, 78:5528-5532.
17. 17 Tew WP, Mahle CD, Benavides J, et al.: Synthesis and characterization of phosphocitric acid, a potent inhibitor of hydroxylapatite crystal growth. Biochemistry 1980, 19:1983-1988.
18. 18 Brown MR, Sallis JD: Urolithiasis and related clinical research. Schwille PO, Smith LH, Robertson WG, Vahlensieck W, eds. New York: Plenum Press, 1985:891-899.
19. 19 Krug HE, Mahowald ML, Halverson PB, Sallis JD, Cheung HS: Phosphocitrate prevents disease progression in murine progressive ankylosis. Arthritis Rheum 1993, 36:1603-1611.
20. 20 Cheung HS, Sallis JD, Mitchell P, Struve JA: Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate. Biochem Biophys Res Commun 1990, 171:20-25.
21. 21 Nair D, Misra RP, Sallis JD, Cheung HS: Phosphocitrate inhibits a basic calcium phosphate and calcium pyrophosphate dihydrate crystal-induced mitogen-activated protein kinase cascade signal transduction pathway. J Biol Chem 1997, 272:18920-18925. This study demonstrated for the first time that p42 and p44 mitogen-activated protein kinase pathway is the mediator of crystal-induced signals to the nucleus.
22. 22 Brogley M, Cruz M, Cheung HS: Basic calcium phosphate crystal induction of MMP-1 and MMP-3 expression is dependent upon a p42/44 mitogen-activated protein kinase signal transduction pathway. J Cell Physiol 1999, 180:215-224. This study shows that BCP crystal induction of MMP-1 and -3 expression and synthesis is dependent upon the p42/p44 MAKP signal transduction pathway.
23. 23 Rasmussen H: The calcium messenger system: part 1. New Engl J Med 1985, 314:1094-1101.
24. 24 Rasmussen H: The calcium messenger system: part 2. New Engl J Med 1986, 314:1164-1170.
25. 25 Halverson PB, Greene A, Cheung HS: Intracellular calcium responses to BCP crystals in fibroblasts. Osteoarthritis Cartilage 1998, 6:324-329. The role of calcium influx as the initial signal of cell activation is identified.
26. 26 Marshall CJ: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1997, 80:179-185.
27. 27 Neary JT: MAPK cascades in cell growth and death. News Physiol Sci 1997, 12:286-293.
28. 28 Bai G, Howell DS, Roos BA, et al.: Crystals upregulate metalloproteinases and downregulate tissue inhibitor of metalloproteinase in human fibroblasts. Osteoarthritis Cartilage, in press.
29. 29 Cheung HS, McCarty DJ: Mitogenesis induced by calcium-containing crystals: role of intracellular dissolution. Exp Cell Res 1985, 157:63-70.
30. 30 McCarthy GM, Cheung HS, Abel SM, Ryan LM: BCP crystal-induced collagenase production: role of intracellular crystal dissolution. Osteoarthritis Cartilage 1998, 6:205-213.
31. 31 Cheung HS, Devine T, Hubbard H: Calcium phosphate particle induction of metalloproteinase: effect of particle sizes. Osteoarthritis Cartilage 1997, 5:145-151.
32. 32 Ryan LM, Cheung HS, LeGeros RZ, et al.: Cellular responses to whitlockite. Calcif Tissue Int 1999, 65:374-377. The authors present evidence that biologic effects of calcium-containing crystals depend on calcium content.