Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Cell

Volumn 80, Issue 2, 1995, Pages 179-185

  Marshall, C J ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

BIOLOGICAL MODEL; ENZYME ACTIVATION; GENETIC ANALYSIS; HUMAN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMAL; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CAENORHABDITIS; DROSOPHILA; ENZYME ACTIVATION; HUMAN; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASE; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0028872649     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90401-8     Document Type: Review

References (79)

1. raf-1
2. Sex stress and integrity: the importance of MAP kinases in yeast
3. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
4. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
5. Identification of Fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle
6. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
7. Signal Transduction via the MAP kinases. Proceed at your own RSK
8. Increased Kit/SCF receptor induced mitogenecity but abolished cell motility after inhibition of protein kinase C
9. The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway
10. Again-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
11. ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
12. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways
13. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit
14. Growth factor signaling: where is the specificity?
15. Nuclear localization and regulation of erk- and rsk-encoded protein kinases
16. Calcium signaling
17. Role of phosphatidylinositol kinase in PDGF receptor signal transduction
18. Multisite phosphorylation of the epidermal growth factor receptor
19. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
20. Genetics of signal transduction in invertebrates
21. Raf functions downstream of Rest in the Sevenless signal transduction pathway
22. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation
23. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function
24. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
25. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
26. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
27. An osmosensing signal transduction pathway in mammalian cells
28. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
29. Establishment of a norandregenic clonal line of rat adrenal phaeochromocytoma cells that respond to nerve growth factor
30. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
31. The β PDGF receptor induces neuronal differentiation of PC12 cells
32. MAP kinase pathways in yeast: for mating and more
33. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
34. Transcriptional regulation by extracellular signals: mechanisms and specificity
35. Activation of the MAP kinase pathway by the protein kinase raf
36. Diffusible factors in vertebrate embryonic induction
37. Negative control of photoreceptor development in Drosophila by the product of the yon gene, an ETS domain protein
38. Ras-dependent growth factor regulation of MEK kinase in PC12 cells
39. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components
40. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site phosphotyrosine 1009 on the PDGF receptor
41. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signaling by protein kinase C
42. Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein
43. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
44. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
45. Transformation of mammalian cells by constitutively active MAP kinase kinase
46. Biphasic and synergistic activation of p44(mapK) (ERK1) by growth factors: correlation between late phase activation and mitogenicity
47. Differential activation of ERK and JNK MAP kinases by Raf-1 and MEKK
48. Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis
49. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21(ras) in rat pheochromocytoma PC12 cells
50. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1 and the 90 kDa ribosomal S6 kinase in PC12 cells
51. Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line
52. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLCγ
53. Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells
54. The torso receptor protein-tyrosine kinase signaling pathway: an endless story
55. Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity
56. SNT, a differentiation-specific target of neurotrophin factor-induced tyrosine kinase activity in neurons and PC12 cells
57. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
58. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
59. Phosphatidylinositol-3-OH kinase as a direct target of Ras
60. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
61. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
62. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
63. SH2/SH3 signaling proteins
64. Activation of ras and other signaling pathways by tyrosine receptor kinases
65. Growth factor signaling by receptor tyrosine kinases
66. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
67. Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells
68. Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
69. Activation of Raf as a result of recruitment to the plasma membrane
70. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
71. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
72. Ternary complex factors growth factor-regulated transcriptional activators
73. A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila
74. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptors mitogenic signal
75. Complex formation between RAS and RAF and other protein kinases
76. v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase
77. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction
78. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator, SEK1
79. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues