Analysis and prediction of absorption profile including hepatic first- pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by Gastrointestinal-Transit- Absorption Model

Drug Metabolism and Disposition

Volumn 28, Issue 5, 2000, Pages 577-581

  Kimura, Toshikiro ^a   Iwasaki, Norio ^a   Yokoe, Jun ichi ^a   Haruta, Shunji ^a   Yokoo, Yoshiaki ^b   Ogawara, Ken ichi ^a   Higaki, Kazutaka ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b SUNTORY LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN; PHENOLSULFONPHTHALEIN; TYRAMINE;

ANIMAL EXPERIMENT; ARTICLE; BEER; BIOAVAILABILITY; DRUG ABSORPTION; DRUG CLEARANCE; DUODENUM; GASTRIN RELEASE; GASTROINTESTINAL TRANSIT; JEJUNUM; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; ALGORITHMS; ANIMALS; BEER; BIOTRANSFORMATION; BLOOD PROTEINS; GASTRINS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; LIVER; MALE; PORTAL VEIN; PROTEIN BINDING; RATS; RATS, WISTAR; TYRAMINE;

ANIMALIA;

EID: 0034009449     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Davies B and Morris T (1993) Physiological parameters in laboratory animals and humans. Pharm Res 10: 1093-1095.
2. Haruta S, Iwasaki N, Ogawara K, Higaki K and Kimura T (1998) Absorption behavior of orally administered drugs in rats treated with propantheline. J Pharm Sci 87:1081-1085.
3. Kakemi K, Sezaki H, Konishi R, Kimura T and Okita A (1970) Effect of bile salts on the gastrointestinal absorption of drugs. II. Mechanism of the enhancement of the intestinal absorption of sutfaguanidine by bile salts. Chem Pharm Bull 18:1034-1039.
4. Lowry OH, Rosebrough NJ, Fair AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
5. Patel VS and Kramer WG (1986) Allopurinol absorption from different sites of the rat gastrointestinal tract. J Pharm Sci 75:275-277.
6. Rane A, Wilkinson GR and Shand DG (1977) Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance. J Pharmacol Exp Ther 200:420-424.
7. Sawamoto T, Haruta S, Kurosaki Y, Higaki K and Kimura T (1997) Prediction of plasma concentration profile of orally administered drugs based on gastrointestinal transit kinetics and absorbability in rats. J Pharm Pharmacol 49:450-457
8. Schanker LS, Shore PA, Brodie BB and Hogben CAM (1957) Absorption of drugs from the stomach. I. The rat. J Pharmacol Exp Ther 120:528-539.
9. Teyssen S, Lenzing T, Gonzalez-Calero O, Korn A, Riepl RL and Singer MV (1997) Alcoholic beverages produced by alcoholic fermentation but not by distillation are powerful stimulants of gastric acid secretion in humans. Gut 40:49-56.
10. Tukker JJ and Poelma FGJ (1988) Site-different absorption in the rat intestine. (Abstract). Third International Conference on Drug Absorption, Edinburgh, pp 45.
11. Yokoo Y, Kohda H, Kusumoto A, Naoki H, Matsumoto N, Amachi T, Suwa Y, Fukazawa H, Ishida H, Tsuji K and Nukaya H (1999) Isolation from beer and structural determination of a potent stimulant of gastrin release. Alcohol Alcohol 34:161-168.