An efficient method for cleavage of epoxides with aromatic amines catalysed by β-cyclodextrin in water

Synlett

Volumn , Issue 3, 2000, Pages 339-340

  Reddy, L Rajender ^a   Reddy, M Arjun ^a   Bhanumathi, N ^a   Rama Rao, K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

amino alcohol; cyclodextrin; Aromatic amine; Epoxide; Water

Indexed keywords

AMINOALCOHOL; AROMATIC AMINE; BETA CYCLODEXTRIN; EPOXIDE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; COVALENT BOND; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0034007447     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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22. General Procedure: β-cyclodextrin (0.0025 mole) was dissolved in distilled water (100 mL), then the epoxide 1 (0.01 mole) dissolved in acetone (1 mL) was added followed by the amine 2 (0.01 mole) in acetone (1 mL) at room temperature. Then the reaction mixture was stirred at room temperature for 24 h and the product was extracted with ethyl acetate (3 × 50 mL). The ethyl acetate layer was dried over anhydrous sodium sulfate and removed in vacuo. The crude product was purified by column chromatography on silica gel (100-200 mesh) using chloroform as eluent.
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