Enhancing our understanding of the molecular responses to hypoxia in mammals using Drosophila melanogaster

Journal of Applied Physiology

Volumn 88, Issue 4, 2000, Pages 1481-1487

  Haddad, Gabriel G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anoxia; Central nervous system; Differential display; Genetics and reverse genetics; Invertebrate models

Indexed keywords

ANOXIA; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; GENETIC MODEL; HYPOXIA; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

DROSOPHILA MELANOGASTER;

EID: 0034006161     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.4.1481     Document Type: Review

References (37)

1. Allada R, White NE, So WV, Hall JC, and Rosbash M. A mutant Drosophila homolog of mammalian clock disrupts circadian rhythms and transcription of period and timeless. Cell 93: 791-804, 1998.
2. Artavanis-Tsakonas S, Rand MD, and Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 284: 770-776, 1999.
3. Aw TY and Jones DP. Respiratory characteristics of neonatal rat hepatocytes. Pediat Res 21: 492-496, 1987.
4. Aw TY and Jones DP. Cyanide toxicity in hepatocytes under aerobic and anaerobic conditions. Am J Physiol Cell Physiol 257: C435-C441, 1989.
5. 2 deprivation: in vitro intracellular studies. Am J Physiol Lung Cell Mol Physiol 262: L549-L554, 1992.
6. 0. J Neurosci 13: 63-72, 1993.
7. Gu XQ and Haddad GG. Drosophila neurons respond differently to hypoxia and cyanide than rat neurons. Brain. Res 845: 6-13, 1999.
8. 2 deprivation in central neurons. Kidney Int 51: 467-472, 1997.
9. 2 deprivation induces a major depolarization in brainstem neurons in the adult but not in the neonatal rat. J Physiol (Lond) 429: 411-428, 1990.
10. 2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol 40: 277-318, 1993.
11. Haddad GG and Mellins RB. Hypoxia and respiratory control in early life. Annu Rev Physiol 46: 629-643, 1984.
12. Haddad GG and Rosen CL. Ventilatory response to hypoxia: Integrated, cellular and molecular aspects. In: Developmental Neurobiology of Breathing Lung Biology in Health and Disease, edited by G. G. Haddad and J. Farber. New York: Dekker, 1991, p. 591-614.
13. 2 deprivation in Drosophila melanogaster. Proc Natl Acad Sci USA 94: 10809-10812, 1997.
14. Jiang C and Haddad GG. The effect of anoxia on intracellular and extracellular potassium activity in hypoglossal neurons in-vitn. J Neurophysiol 66: 103-111, 1991.
15. + channels during anoxia: major differences between rat (newborn, adult) and turtle neurons. J Physiol (Lond) 448: 599-612, 1992.
16. + current in central neurons. Brain Res 64: 352-356, 1993.
17. + channel independently of cytosolic factors in central neurons. J Physiol (Lond) 481: 15-26, 1994.
18. + channels in substantia nigra neurons, J Neurosci 14: 5590-5602, 1994.
19. Krishnan SN, Sun YA, Mohsenin A, Wyman RJ, and Haddad GG. Behavioral and electrophysiological responses of Drosophila melanogaster to prolonged periods of anoxia. J Insect Physiol 43: 203-210, 1997.
20. Kwei S, Jiang C, and Haddad GG. Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal morphology in rat hippocampus. Brain Res 620: 203-210, 1993.
21. Liang P and Pardee AB. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257: 967-971, 1992.
22. Lin YJ, Seroude L, and Benzer S. Extended life span and stress resistance in the Drosophila mutant Methuselah. Science 282: 943-960, 1998.
23. Ma E and Haddad GG. Isolation and characterization of the hypoxia-inducible factor Ia in Drosophila melanogaster. Brain Res. Mol Brain Res. 73:11-16, 1999.
24. Ma E and Haddad GG. Low oxygen stress and the role of gene expression in anoxia resistance. In: Cell and Molecular Responses to Stress, edited by Storey KB and Storey JM. Stamford, CT: JAI. In press.
25. 2 deprivation: an anoxia-regulated novel gene in Drosophila melanogaster. Mol Brain Res 63: 217-224, 1999.
26. Marks JD, Donnelly DF, and Haddad GG. Adenosineinduced inhibition of vagal motoneuron excitability: receptor subtype and mechanisms. Am J Physiol Lung Cell Mol Physiol 264: L124-L132, 1993.
27. Metzger RJ and Krasnow MA. Genetic control of branching morphogenesis. Science 284: 1635-1639, 1999.
28. Metzstein MM, Stanfleld GM, and Horvitz JR. Genetics of programmed cell death in C. elegans: past, present and future. Trends Genet 14: 410-416, 1998.
29. Moore MD, DeZarro J, Luk AY, Tully T, Singh CM, and Heberlein U. Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997-1007, 1998.
30. + current in rat hippocampal neurones via protein kinase C. J Physiol (Lond) 503.3: 479-488, 1997.
31. Park M, Lewis C, Turbay D, Chung A, Chen JN, Evans S, Breitbart RE, Fishman MC, Izumo S, and Bodmer R. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes. Proc Natl Acad Sci USA 95: 9366-9371, 1998.
32. Rosen CL, Schecter WS, Mellins RB, and Haddad GG. Effect of acute hypoxia on metabolism and ventilation in awake piglets. Respir Physiol 91: 307-319, 1993.
33. Su MT, Fujioka M, Goto T, and Bodmer R. The Drosophila homeobox genes zft-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision. Development 126: 3241-3251, 1999.
34. Tischkau SA, Barnes JA, Lin F, Meyers EM, Soucy JW, Meyer-Bernstein EL, Hurst WJ, Burgoon PW, Chen D, Sehgal A, and Gillette MU. Oscillation and light induction of timeless of mRNAin the mammalian circadian clock. J Neurosci 19: RC15, 1999.
35. Wingrove J and O'Farrell PH. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Cell 98: 105-114, 1999.
36. Xia Y, Jiang C, and Haddad GG. Oxidative and glycolytic pathways in rat (newborn, adult) and turtle brain: role during anoxia. Am J Physiol Regulatory Integrative Comp Physiol 262: R595-R603, 1992.
37. Young RS, During MJ, Donnelly DF, Aquila WJ, Perry VL, and Haddad GG. Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis study. Am J Physiol Regulatory Integrative Comp Physiol 264: R716-R719, 1993.