Recombinant subunit ORF2.1 Antigen and induction of antibody against immunodominant epitopes in the hepatitis E virus capsid protein

Journal of Medical Virology

Volumn 60, Issue 4, 2000, Pages 379-386

  Li, Fan ^a,b   Riddell, Michaela A ^a,b   Seow, Heng Fong ^a,c   Takeda, Naokazu ^d   Miyamura, Tatsuo ^d   Anderson, David A ^a,b  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^b Australian Ctr for Hepat Virology   (Australia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Convalescent reactivity; Hepatitis E virus; Immunodominant epitopes; Subunit vaccine

Indexed keywords

ALUMINUM HYDROXIDE; CAPSID PROTEIN; EPITOPE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; BACULOVIRUS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HEPATITIS E VIRUS; IMMUNIZATION; IMMUNOSTIMULATION; NONHUMAN; RAT; VIRUS CAPSID; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BLOTTING, WESTERN; CAPSID; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; HEPATITIS E VIRUS; HUMANS; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; TITRIMETRY; VIRAL PROTEINS;

ANIMALIA; ESCHERICHIA COLI; HEPATITIS E VIRUS; MIRIDAE; RNA VIRUSES; UNIDENTIFIED BACULOVIRUS;

EID: 0034004309     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(200004)60:4<379::AID-JMV3>3.0.CO;2-X     Document Type: Article

References (33)

1. Anderson DA, Li F, Riddell MA, Howard T, Seow H-F, Torresi J, Perry G, Sumarsidi D, Shrestha SM, Shrestha IL. 1999. ELISA for IgG-class antibody to hepatitis E virus based on a highly conserved, conformational epitope expressed in Escherichia coli. J Virol Meth 81:131-142.
2. Balayan M, Usmanov R, Zamyatina N, Djumalieva DI, Karas FR. 1990. Brief report: experimental hepatitis E infection in domestic pigs. J Med Virol 32:58-59.
3. Bradley DW. 1995. Hepatitis E virus: a brief review of the biology, molecular virology, and immunology of a novel virus. J Hepatol 22:140-145.
4. Bradley DW, Krawczynski K, Cook EH Jr., McCaustland KA, Humphrey CD, Spelbring JE, Myint H, Maynard JE. 1987. Enterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles. Proc Natl Acad Sci USA 84:6277-6281.
5. Dawson GJ, Chau KH, Cabal CM, Yarbough PO, Reyes GR, Mushahwar IK. 1992. Solid-phase enzyme-linked immunosorbent assay for hepatitis E virus IgG and IgM antibodies utilizing recombinant antigens and synthetic peptides. J Virol Meth 38:175-186.
6. Fuerst TR, Yarbough PO, Zhang Y, McAtee P, Tam A, Lifson J, McCaustland K, Spellbring J, Bradley D, Margolis HS, Francotte M, Garcon N, Slaoui M, Prieels JP, Krawczynski K. 1996. Prevention of hepatitis E using a novel ORF-2 subunit vaccine. In: Buisson Y, Coursaget P, Kane M, editors. Enterically-transmitted Hepatitis Viruses. La Simarre: Joue-les-Tours. p 384-392.
7. Goldsmith R, Yarbough PO, Reyes GR, Fry KE, Gabor KA, Kamel M, Zakaria S, Amer S, Gaffar Y. 1992. Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egyptian children. Lancet 339:328-331.
8. He J, Ching WM, Yarbough P, Wang H, Carl M. 1995. Purification of a baculovirus-expressed hepatitis E virus structural protein and utility in an enzyme-linked immunosorbent assay. J Clin Microbiol 33:3308-3311.
9. Heath TC, Burrow JN, Currie BJ, Bowden FJ, Fisher DA, Demediuk BH, Locarnini SA, Anderson DA. 1995. Locally acquired hepatitis E in the Northern Territory of Australia. Med J Aust 162:318-319.
10. Huang CC, Nguyen D, Fernandez J, Yun KY, Fry KE, Bradley DW, Tam AW, Reyes GR. 1992. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191:550-558.
11. Kane MA, Bradley DW, Shrestha SM, Maynard JE, Cook EH, Mishra RP, Joshi DD. 1984. Epidemic non-A, non-B hepatitis in Nepal: recovery of a possible etiologic agent and transmission studies in marmosets. JAMA 252:3140-3145.
12. Karetnyi I, Dzhumalieva DI, Usmanov RK, Titova IP, Litvak I, Balaian MS. 1993. The possible involvement of rodents in the spread of viral hepatitis E. J Microbiol Epidemiol Immunol 4:52-56. [In Russian.]
13. Khudyakov YE, Favorov MO, Jue DL, Hine TK, Fields HA. 1994a. Immunodominant antigenic regions in a structural protein of the hepatitis E virus. Virology 198:390-393.
14. Khudyakov YE, Favorov MO, Khudyakova NS, Cong ME, Holloway BP, Padhye N, Lambert SB, Jue DL, Fields HA. 1994b. Artificial mosaic protein containing antigenic epitopes of hepatitis E virus. J Virol 68:7067-7074.
15. Khudyakov YE, Khudyakova NS, Fields HA, Jue D, Starling C, Favorov MO, Krawczynski K, Polish L, Mast E, Margolis H. 1993. Epitope mapping in proteins of hepatitis E virus. Virology 194:89-96.
16. Kwo PY, Schlauder GG, Carpenter HA, Murphy PJ, Rosenblatt JE, Dawson GJ, Mast EE, Krawczynski K, Balan V. 1997. Acute hepatitis E by a new isolate acquired in the United States. Mayo Clin Proc 72:1133-1136.
17. Li F, Zhuang H, Kolivas S, Locarnini S, Anderson D. 1994. Persistent and transient antibody responses to hepatitis E virus detected by Western immunoblot using open reading frame 2 and 3 and glutathione-S-transferase fusion proteins. J Clin Microbiol 32:2060-2066.
18. Li F, Torresi J, Locarnini SA, Zhuang H, Zhu W, Guo X, Anderson DA. 1997a. Amino-terminal epitopes are exposed when full-length open reading frame 2 of hepatitis E virus is expressed in Escherichia coli, but carboxy-terminal epitopes are masked. J Med Virol 52:289-300.
19. Li TC, Yamakawa Y, Suzuki K, Tatsumi M, Razak MA, Uchida T, Takeda N, Miyamura T. 1997b. Expression and self-assembly of empty virus-like particles of hepatitis E virus. J Virol 71: 7207-7213.
20. Maneerat Y, Clayson ET, Myint KS, Young GD, Innis BL. 1996. Experimental infection of the laboratory rat with the hepatitis E virus. J Med Virol 48:121-128.
21. McAtee CP, Zhang Y, Yarbough PO, Bird T, Fuerst TR. 1996. Purification of a soluble hepatitis E open reading frame 2-derived protein with unique antigenic properties. Protein Expr Purif 8:262-270.
22. Meng X-J, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, Haynes JS, Thacker BJ, Emerson SU. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A 94:9860-9865.
23. Meng J, Pillot J, Dai X, Fields HA, Khudyakov YE. 1998a. Neutralization of different geographic strains of the hepatitis E virus with anti-hepatitis E virus-positive serum samples obtained from different sources. Virology 249:316-324.
24. Meng XJ, Halbur PG, Haynes JS, Tsareva TS, Bruna JD, Royer RL, Purcell RH, Emerson SU. 1998b. Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV. Arch Virol 143:1405-1415.
25. Meng XJ, Halbur PG, Shapiro MS, Govindarajan S, Bruna JD, Mushahwar IK, Purcell RH, Emerson SU. 1998c. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 72:9714-9721.
26. Purdy MA, McCaustland KA, Krawczynski K, Spelbring J, Reyes GR, Bradley DW. 1993. Preliminary evidence that a trpE-HEV fusion protein protects cynomolgus macaques against challenge with wild-type hepatitis E virus (HEV). J Med Virol 41:90-94.
27. Reyes GR, Purdy MA, Kim JP, Luk KC, Young LM, Fry KE, Bradley DW. 1990. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247:1335-1339.
28. Robinson RA, Burgess WH, Emerson SU, Leibowitz RS, Sosnovtseva SA, Tsarev S, Purcell RH. 1998. Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. Protein Expr Purif 12:75-84.
29. Schlauder GG, Dawson GJ, Erker JC, Kwo PY, Knigge MF, Smalley DL, Rosenblatt JE, Desai SM, Mushahwar IK. 1998. The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States. J Gen Virol 79:447-456.
30. Tsarev SA, Tsareva TS, Emerson SU, Kapikian AZ, Ticehurst J, London W, Purcell RH. 1993. ELISA for antibody to hepatitis E virus (HEV) based on complete open-reading frame-2 protein expressed in insect cells: identification of HEV infection in primates. J Infect Dis 168:369-378.
31. Tsarev SA, Tsareva TS, Emerson SU, Govindarajan S, Shapiro M, Gerin JL, Purcell RH. 1994. Successful passive and active immunization of cynomolgus monkeys against hepatitis E. Proc Natl Acad Sci U S A 91:10198-10202.
32. Tsarev SA, Tsareva TS, Emerson SU, Govindarajan S, Shapiro M, Gerin JL, Purcell RH. 1997. Recombinant vaccine against hepatitis E: dose response and protection against heterologous challenge. Vaccine 15:1834-1838.
33. Yarbough PO, Tam AW, Fry KE, Krawczynski K, McCaustland KA, Bradley DW, Reyes GR. 1991. Hepatitis E virus: identification of type-common epitopes. J Virol 65:5790-5797.