Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice

Journal of Lipid Research

Volumn 41, Issue 2, 2000, Pages 205-213

  Martins, Ian J ^a   Hone, Eugene ^a   Chi, Caroline ^a   Seydel, Ulrich ^a   Martins, Ralph N ^b   Redgrave, Trevor G ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b HOLLYWOOD PRIVATE HOSPITAL   (Australia)

Author keywords

ApoE; Breath test; Cholesteryl; Chylomicron remnant; Emulsion; Fibroblast; Low density lipoprotein receptor; Low density lipoprotein receptor related protein; Mice; Oleate

Indexed keywords

APOLIPOPROTEIN E; CARBON 13; CARBON DIOXIDE; CHYLOMICRON; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; OLEIC ACID;

ANIMAL CELL; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; EMULSION; FIBROBLAST CULTURE; GENOTYPE; HUMAN; HUMAN CELL; LIPID METABOLISM; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; APOLIPOPROTEINS E; BIOLOGICAL TRANSPORT, ACTIVE; CARBON DIOXIDE; CELL LINE; CELLS, CULTURED; CHYLOMICRONS; EMULSIONS; FIBROBLASTS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LACTOFERRIN; LDL-RECEPTOR RELATED PROTEIN 1; LIPOPROTEINS, LDL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; SURAMIN;

EID: 0034001470     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Havel, R. J. 1986. Functional activities of hepatocytic lipoprotein receptors. Annu. Rev. Physiol. 48: 119-134.
2. Redgrave, T. G., I. J. Martins, and B. C. Mortimer. 1995. Measurement of expired carbon dioxide to assess the metabolism of remnant lipoproteins. J. Lipid Res. 36: 2670-2675.
3. 2 breath test for the assessment remnant metabolism in mice. J. Lipid Res. 39: 691-698.
4. Herz, J., U. Hamann, S. Rogne, O. Myklebost, H. Gausepohl, and K. K. Stanley. 1988. Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-rereptor suggest a physiological role as lipoprotein receptor. EMBO J. 7: 4119-4127.
5. Willnow, T. E., S. Sheng, S. Ishibashi, and J. Herz. 1994. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 264: 1471-1474.
6. Willnow, T. E., S. A. Armstrong, R. E. Hammer, and J. Herz. 1995. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc. Natl. Acad. Sci. USA. 92: 4537-4541.
7. Strickland, D. K., J. D. Ashcom, S. Williams, W. H. Burgess, M. Migliorini, and W. S. Argraves. 1990. Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor J. Biol. Chem. 265: 17401-17404.
8. Lund, H., K. Takahashi, R. L. Hamilton, and R. J. Hamilton. 1989. Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver. Proc. Natl. Acad. Sci. USA. 86: 9318-9322.
9. Rohlmann, A., M. Gotthardt, R. E. Hammer, and J. Herz. 1998. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101: 689-695.
10. Mokuno, H., S. Brady, L. Kotite, J. Herz, and R. J. Havel. 1994. Effect of 39 kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants. J. Biol. Chem. 269: 13238-13243.
11. Herz, J., J. L. Goldstein, D. K. Strickland, Y. K. Ho, and M. S. Brown. 1991. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J. Biol. Chem. 266: 21232-21238.
12. Callow, M. J., J. Verstuyft, R. Tangirala, W. Palinski, and E. M. Rubin. 1995. Atherogenesis in transgenic mice with human apolipoprotein B and lipoprotein (a). J. Clin. Invest. 96: 1639-1646.
13. Martins, I. J., C. Vilcheze, B-C. Mortimer, R. Bittman, and T. G. Redgrave. 1998. Sterol side chain length and structure affect the clearance of chylomicron-like emulsions in rats and mice. J. Lipid Res. 39: 302-312.
14. Marchonis, J. J. 1969. An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochem. J. 113: 299-305.
15. 3. Clin. Chem. 29: 656-663.
16. Bartlett, G. R. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234: 466-468.
17. Carlson, L. A. 1963. Determination of serum triglycerides. J. Atheroscler. Res. 3: 333-336.
18. Zlatkis, A., and B. Zak. 1969. Study of a new cholesterol reagent. Anal. Biochem. 29: 143-148.
19. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurements with Folin phenol reagent. J. Biol. Chem. 193: 265-275.
20. Mortimer, B-C., D. J. Beveridge, I. J. Martins, and T. G. Redgrave. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of LDL receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE dependent pathway. J. Biol. Chem. 270: 28767-28776.
21. Mahley, R. W. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 29: 622-630.
22. Callow, M. J., B-C. Mortimer, and T. G. Redgrave, 1993. Charge effects on chylomicron clearance in rats. Biochem. Mol. Biol. Int. 29: 913-919.