Expression of human Wiskott-Aldrich syndrome protein in patients' cells leads to partial correction of a phenotypic abnormality of cell surface glycoproteins

Gene Therapy

Volumn 7, Issue 4, 2000, Pages 314-320

  Huang, M M ^a,e   Tsuboi, S ^b   Wong, A ^a   Yu, X J ^a   Oh Eda, M ^b   Derry, J M ^c,f   Francke, U ^c,d   Fukuda, M ^b   Weinberg, K I ^a   Kohn, D B ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b BURNHAM INSTITUTE   (United States)

^c STANFORD UNIVERSITY   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f AMGEN INC   (United States)

Author keywords

Gene therapy; Glycosyltransferase; Hematopoietic cells; O glycosylation; Wiskott Aldrich syndrome

Indexed keywords

BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; CELL SURFACE PROTEIN; COMPLEMENTARY DNA; GLYCOPROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOBLAST; BONE MARROW; CELL CULTURE; CELL TRANSFORMATION; ECZEMA; ENZYME ACTIVITY; EPSTEIN BARR VIRUS; EXPRESSION VECTOR; GENE THERAPY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOBLOTTING; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; SIMIAN VIRUS 40; THROMBOCYTOPENIA; WISKOTT ALDRICH SYNDROME;

ANIMALIA; HUMAN HERPESVIRUS 4; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40; VESPIDAE;

EID: 0033994632     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301085     Document Type: Article

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