Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices

Epilepsia

Volumn 41, Issue 1, 2000, Pages 28-33

  Armand, V ^a,c,d   Rundfeldt, C ^b   Heinemann, U ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ASTA MEDICA AG   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d CENTRE PAUL BROCA   (France)

Author keywords

Entorhinal cortex; Epileptiform activities; Hippocampus; Low magnesium; Retigabine

Indexed keywords

ANTICONVULSIVE AGENT; MAGNESIUM; RETIGABINE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPTIC DISCHARGE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033989219     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb01501.x     Document Type: Article

References (38)

1. Kapetanovic IM, Rundfeldt C. D-23129: a new anticonvulsant compound. CNS Drug Rev 1996;2:308-21.
2. Rostock A, Tober C, Rundfeldt C, et al. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res 1996;23:211-23.
3. Tober C, Rundfeldt C, Rostock A, Bartsh R. The phenyl carbamic acid ester D-23129 is highly effective in epilepsy models for generalized and focal seizures at nontoxic doses. Soc Neurosci Abstr 1994;20:1641.
4. Tober C, Rostock A, Rundfeldt C, Bartsh R. D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. Eur J Pharmacol 1996;303:163-9.
5. Tober C, Rostock A, Bartsh R. The phenylcarbamic acid ester D-23129 is highly effective against amygdala kindled seizures in rats. Eur J Pharmacol 1994;suppl 7:212.
6. Dailey JW, Cheong JH, Ko KH, Adams-Curtis LE, Jobe PC. Anticonvulsant properties of D-23129 in genetically epilepsy-prone rats: prediction of clinical response. Neurosci Lett 1995;195:77-80.
7. Yonekawa WD, Kapetanovic IM, Kupferberg HJ. The effects of anticonvulsant agents on 4-aminopyridine-induced epileptiform activity in rat hippocampus in vitro. Epilepsy Res 1995;20:137-50.
8. Kapetanovic IM, Yonekawa WD, Kupferberg HJ. The effects of D-23129, a new experimental anticonvulsant drug on neurotransmitter amino acids in the rat hippocampus in vivo. Epilepsy Res 1995;22:167-73.
9. Rundfeldt C, Rohlfs A, Netzer R. Multiple actions of the new anticonvulsant D-23129 on voltage-gated inward currents and GABA-induced currents in cultured neuronal cells. Naunyn Schmiedebergs Arch Pharmacol 1995;suppl 351:R160.
10. Rundfeldt C, Tober C, Ganguly A, Wolf HH, White HS. Potassium channel opening properties of D-23129 an anticonvulsant with potent effects in rodents models for generalized and focal seizures. Soc Neurosci Abstr 1995;21:203.
11. + channels in neuronal cells. Eur J Pharmacol 1997;336:243-9.
12. Yonekawa WD, Kapetanovic IM, Kupferberg HJ. The effects of D-23129 (ADD 230001) and standard anticonvulsant on the pair-pulse paradigm in rat hippocampus in vitro. Soc Neurosci Abstr 1995;21:R2117.
13. Jones RSG, Heinemann U. Synaptic and intrinsic responses of medial enlorhinal cortex cells in normal and magnesium-free medium in vitro. J Neurophysiol 1988;59:1476-96.
14. Anderson WW, Lewis DV, Swartzwelder HS, Wilson WA. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res 1986;398:215-9.
15. Mody I, Lambert JDC, Heinemann U. Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J Neurophysiol 1987;57:869-88.
16. Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B. Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium. Neurosci Lett 1986;69:156-61.
17. 2+] in CA1-region of rat hippocampal slices. Neurosci Lett 1987;75:240-5.
18. Dreier JP, Heinemann U. Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid. Neurosci Lett 1990;119:68-70.
19. Heinemann U, Arens J, Dreier JP, Stabel J, Zhang CL. In vitro epileptiform activity: role of excitatory amino acids. Epilepsy Res 1991;10:18-23.
20. Zhang CL, Heinemann U. Effects of the triazole derivative loreclezole (R72063) on stimulus induced ionic and field potential responses and on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices. Naunyn Schmiedebergs Arch Pharmacol 1992;346:581-7.
21. Zhang CL, Dreier JP, Heinemann U. Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res 1995;20:105-11.
22. Zhang CL, Chatterjee SS, Stein U. Heinemann U. Comparison of the effects of losigamone and its isomers on maximal electroshock induced convulsions in mice and on three different patterns of low magnesium induced epileptiform activity in slices of the rat temporal cortex. Naunyn Schmiedebergs Arch Pharmacol 1992;345: 85-92.
23. 2+ induced epileptiform activity in rat hippocampal and entorhinal cortex slices during adolescence. Dev Brain Res 1995;87:145-52.
24. Köhr G, Heinemann U. Anticonvulsive properties of ketamine and 2-aminophosphonovalerate in the low magnesium epilepsy in rat hippocampal slices. Neurosci Res Commun 1987;1:17-21.
25. 2+ induced epileptiform activity in rat temporal cortex slices: development of pharmacoresistant epileptiform activity. Eur J Physiol 1991;suppl 418:R10.
26. Rey E, Pons G, Olive G. Vigabatrin: clinical pharmacokinetics Clin Pharmacokinet 1992;23:267-78.
27. Sanchez-Alcaraz A, Quintana B, Rodriguez I, Lopez E. Plasma concentrations of vigabatrin in epileptic patienls. J Clin Pharmacol Ther 1996;21:393-8.
28. Löscher W, Fassbender CP, Gram L, et al. Determination of GABA and vigabatrin in human plasma by a rapid and simple HPLC method: correlation between clinical response to vigabatrin and increase in plasma GABA. Epilepsy Res 1993;14:245-55.
29. Herron CE, Williamson R, Collingridge GL. A selective N-methyl-B-aspartate antagonist depresses epileptiform activity in rat hippocampal slices. Neurosci Lett 1985;61:255-60.
30. Köhr G, Heinemann U. Anticonvulsive properties of ketamine and 2-aminophosphonovalerate in the low magnesium epilepsy in rat hippocampal slices. Neurosci Res Commun 1987;1:17-21.
31. Viana F, Bayliss DA, Berger AJ. Multiple potassium conductances and their role in action potential repolarization and repetitive firing behavior of neonatal rat hypoglossal motoneurons. J Neurophysiol 1993;69:2150-63.
32. Beck H, Blumcke I, Kral T, et al. Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilensia 1996;37:892-901.
33. Beck H, Clusmann H, Kral T, Schramm J, Heinemann-U, Elger CE. Potassium currents in acutely isolated human hippocampal dentate granule cells. J Physiol (Lond) 1997;498:73-85.
34. During MJ, Ryder KM, Spencer DD. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature 1995;376:174-7.
35. Lampe H, Bigalke H. Carbamazepine blocks NMDA-activated currents in cultured spinal cord neurons. Neuroreport 1990;5:26-8.
36. Rush AM, Elliott JR. Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia. Neurosci Lett 1997;266:95-8.
37. Rogawski MA, Porter RJ. Antiepileptic drugs: pharmacological mechanism and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 1990;42:223-86.
38. + currents: quantitative distinction from phenytoin and possible therapeutic implications. Mol Pharmacol 1997;51:1077-88.