Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum

Neuroscience Letters

Volumn 278, Issue 3, 2000, Pages 137-140

  Hillsley, Kirk ^a   Eeckhout, Chris ^b   Grundy, David ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

Irritable bowel syndrome; Jejunum; Sensory; Serotonin; Small intestine; Vagus

Indexed keywords

CILANSETRON; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; ELECTROPHYSIOLOGY; IRRITABLE COLON; JEJUNUM; MALE; MESENTERY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SINGLE UNIT ACTIVITY; VAGUS NERVE; WAVEFORM;

ABSORPTION; ADMINISTRATION, TOPICAL; ANIMALS; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ENTERIC NERVOUS SYSTEM; INJECTIONS, INTRAVENOUS; JEJUNUM; MALE; NERVE FIBERS; NEURONS, AFFERENT; PYRIDINES; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0033988702     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00923-4     Document Type: Article

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