Human CD4 residue Phe 43 is critical for repertoire development and maturation of MHC class II restricted CD4 single-positive T lineage cells in vivo

European Journal of Immunology

Volumn 30, Issue 1, 2000, Pages 279-290

  Sakihama, Toshiko ^a   Hunsicker, Mary E ^a   Hussey, Rebecca E ^a   Reinherz, Ellis L ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

CD4; Coreceptor function; MHC class II; T cell repertoire; Transgenic mouse

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHENYLALANINE; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033987092     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200001)30:1<279::AID-IMMU279>3.0.CO;2-5     Document Type: Article

References (46)

1. Reinherz, E. L., Kung, P. C., Goldstein, G. and Schlossman, S. F., Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. USA 1979. 76: 4061-4065.
2. Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H. and Schlossman, S. F., Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T cell lineage. Proc. Natl. Acad. Sci. USA 1980. 77: 1588-1592.
3. Harrison, S. C., Wang, J., Garret, T., Liu, J., Moebius, U. and Reinherz, E. L., Structure and interactions of CD4. Cold Spring Harb. Symp. Quant. Biol. 1992. 57: 541-548.
4. Moebius, U., Pallai, P., Harrison, S. C. and Reinherz, E. L., Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding. Proc. Natl. Acad. Sci. USA 1993. 90: 8259-8263.
5. Konig, R., Huang, L. Y. and Germain, R. N., MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 1992. 356: 796-798.
6. Sakihama, T., Smolyar, A. and Reinherz, E. L., Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. Proc. Natl. Acad. Sci. USA 1995. 92: 6444-6448.
7. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 1990. 60:755-765.
8. Janeway, C. A., Jr., The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 1992. 10: 645-674.
9. Sakihama, T., Smolyar, A. and Reinherz, E. L., Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules. Immunol. Today 1995. 16:581-587.
10. Germain, R. N., T cell signaling: the importance of receptor clustering. Curr. Biol 1997. 7: 640-644.
11. + cells but markedly decreased helper activity in mice lacking CD4. Nature 1991. 353: 180-184.
12. Killeen, N., Sawada, S. and Littman, D. R., Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 1993. 12: 1547-1553.
13. Locksley, R. M, Reiner, S. L., Hatam, F., Littman, D. R. and Killeen, N., Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice. Science 1993. 261: 1448-1451.
14. Rahemtulla, A., Kundig, T. M., Narendran, A., Bachmann, M. F., Julius, M., Paige, C. J., Ohashi, P., Zinkernagel, R. M. and Mak, T. W., Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur. J. Immunol. 1994. 24: 2213-2218.
15. II ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 1992. 89: 12008-12012.
16. lck with CD4 in antigen-specific signal transduction in T cells. Cell 1991, 64: 511-520.
17. von Hoegen, P., Miceli, M. C., Tourvieille, B., Schilham, M. and Parnes, J. R., Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma. J. Exp. Med. 1989. 170: 1879-1886.
18. Law, Y. M., Yeung, R. S. M., Mamalaki, C., Kioussis, D, Mak, T. W. and Flavell, R. A., Human CD4 restores normal T cell development and function in mice deficient in murine CD4. J. Exp. Med. 1994. 179: 1233-1242.
19. Sawada, S., Scarborough, J. D., Killeen, N. and Littman, D. R., A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 1994. 77: 917-929.
20. Meuer, S. C., Schlossman, S. F. and Reinherz, E. L., Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl. Acad. Sci. USA 1982. 79: 4395-4399.
21. 240. Hum. Immunol. 1991. 30: 99-104.
22. Clayton, L. K., Sieh, M., Pious, D. A. and Reinherz, E. L., Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature 1989. 339: 548-551.
23. lck association. Nature 1993. 364: 729-732.
24. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 1995. 182: 993-1004.
25. + thymocytes selected by MHC class I molecules. Science 1994. 263: 1774-1778.
26. Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennik, J. R. and Brutkiewicz, R. R., CD1 recognition by mouse NK1 + T lymphocytes. Science 1995. 268: 863-865.
27. -CD8 T cells in mice and humans. J. Exp. Med. 1994. 180: 1097-1106.
28. Matechak, E. O., Killeen, N., Hedrick, S. M. and Fowlkes, B. J., MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 1996. 4: 337-347.
29. Swain, S. L., Croft, M., Dubey, C., Haynes, L., Rogers, P., Zhang, X. and Bradley, L. M., From naive to memory T cells. Immunol. Rev. 1996. 150: 143-167.
30. Dutton, R. W., Bradley, L. M. and Swain, S. L., T cell memory. Annu. Rev. Immunol. 1998. 16: 201-223.
31. Zuniga-Pflucker, J. C., McCarthy, S. A., Weston, M., Longo, D. L., Singer, A. and Kruisbeek, A. M., Role of CD4 in thymocyte selection and maturation. J. Exp. Med. 1989. 169: 2085-2096.
32. Ramsdell, F. and Fowlkes, B. J., Engagement of CD4 and CD8 accessory molecules is required for T cell maturation. J. Immunol. 1989. 143: 1467-1471.
33. + T cells in vivo. Proc. Natl. Acad. Sci. USA 1998. 95: 4493-4498.
34. Mostaghel, E. A, Riberdy, J. M., Steeber, D. A. and Doyle, C., Coreceptor-independent T cell activation in mice expressing MHC class II molecules mutated in the CD4 binding domain. J. Immunol. 1998. 161: 6559-6566.
35. + T lymphocytes in transgenic mice expressing mutant MHC class II deficient in their interaction with CD4. J. Immunol. 1998. 161: 6629-6637.
36. k do not impede CD4+ T cell development. J. Immunol. 1999. 162: 1348-1358.
37. Yelon, D., Spain, L. M., Lim, K. and Berg, L. J., Alterations in CD4 dependence accompany T cell development and differentiation. Int. Immunol. 1996. 8: 1077-1090.
38. Kaye, J., Vasquez, N. J. and Hedrick, S. M., Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol. 1992. 148: 3342-3353.
39. Vignali, D. A. A., Carson, R. T., Chang, B., Mittler, R. S. and Strominger, J. L., The two membrane proximal domains of CD4 interact with the T cell receptor. J. Exp. Med. 1996. 183: 2097-2107.
40. Vignali, D. A. A. and Vignali, K. M., Profound enhancement of T cell activation mediated by the interaction between the TCR and the D3 domain of CD4. J. Immunol. 1999. 162: 1431-1439.
41. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287-296.
42. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 1969-1980.
43. + T cells in major histocompatibility complex clas II-deficient mice. Science 1991. 253: 1417-1420.
44. + T cells. Science 1990. 248: 1227-1230.
45. Madden, P. J., Littman, D. R., Goodfrey, M., Madden, D. E., Chess, L. and Axel, R., The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: A new member of the immunoglobulin gene family. Cell 1985. 42: 93-104.
46. Hogan, B. L. M., Constantini, F. and Lacy, E. (Eds.) Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1986.