The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density

Osteoarthritis and Cartilage

Volumn 8, Issue 1, 2000, Pages 44-52

  Lee, G M ^a   Paul, T A ^a   Slabaugh, M ^a   Kelley, S S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Articular cartilage; Chondrons; Osteoarthritis; Type VI collagen

Indexed keywords

COLLAGEN TYPE 2; COLLAGEN TYPE 6; KERATAN SULFATE;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE MATRIX; CELL SIZE; CELL SWELLING; CONTROLLED STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDRODYNAMICS; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; RELATIVE DENSITY;

EID: 0033986438     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1999.0269     Document Type: Article

References (29)

1. Qi W-N, Scully S. Extracellular collagen modulates the regulation of chondrocytes by transforming growth factor-β1. J Orthop Res. 15:1997;483-490.
2. Homandberg G, Hui F, Wen C, Purple C, Bewsey K, Koepp H. Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines. Biochem J. 321:1997;751-757.
3. Loeser R. Growth factor regulation of chondrocyte integrins: differential effects of insulin-like growth factor 1 and transforming growth factor-β on α1β1 integrin expression and chondrocyte adhesion to type VI collagen. Arthritis Rheum. 40:1997;270-276.
4. Yonezawa I, Kato K, Yagita H, Yamauchi Y, Okumura K. VLA-5-mediated interaction with fibronectin induces cytokine production by human chondrocytes. Biochem Bioph Res Comm. 219:1996;261-265.
5. Chang J, Poole CA. Sequestration of type VI collagen in the pericellular microenvironment of adult chondrocytes cultured in agarose. Osteoarthritis Cart. 4:1996;275-285.
6. Chow G, Nietfeld JJ, Knudson CB, Knudson W. Antisense inhibition of chondrocyte cd44 expression leading to cartilage chondrolysis. Arthritis Rheum. 41:1998;1411-1419.
7. Dodge GR, Poole AR. Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin-1. J Clin Invest. 83:1989;647-661.
8. Lee, GM, Loeser, RF, Interactions of the chondrocyte with its pericellular matrix, Cells and Materials.
9. Mitchell N, Shepard N. Pericellular proteoglycan concentrations in early degenerative arthritis. Arthritis Rheum. 24:1981;958-964.
10. Hwang W, Li B, Jin L, Ngo K, Schachar N, Hughes G. Collagen fibril structure of normal, aging, and osteoarthritic cartilage. J Pathol. 167:1992;425-433.
11. Pelletier J-P, Martel-Pelletier J, Altman R, Mnaymneh LG-à, Howell D, Woessner J. Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum. 26:1983;866-874.
12. Hambach L, Neureiter D, Zeiler G, Kirchner T, Aigner T. Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage. Arthritis Rheum. 41:1998;986-996.
13. von der Mark K, Kirsch T, Nerlich A, Kuss A, Weseloh G, Gluckert K, Stoss H. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum. 35:1992;806-811.
14. Walker GD, Fischer M, Gannon J, Thompson RC Jr, Oegema TR Jr. Expression of type-X collagen in osteoarthritis. J Orthop Res. 13:1995;4-12.
15. Poole CA, Matsuoka A, Scofield JR. Chondrons from articular cartilage. III. Morphologic changes in the cellular microenvironment of chondrons isolated from osteoarthritic cartilage. Arthritis Rheum. 34:1991;22-35.
16. Benninghoff A. Form und bau der Gelenkknorpel in ihren Beziehungen zur Funktion. Zweiter Teil: der Aufbau des Gelenkknorpels in sienen Beziehungen zur Funktion. Z Zellforsch. 2:1925;783.
17. Greco F, Specchia N, Falciglia F, Toesca A, Nori S. Ultrastructural analysis of the adaptation of articular cartilage to mechanical stimulation. J Orthop Traumatol. 18:1992;311-321.
18. Poole C, Flint M, Beaumont B. Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilage. J Orthop Res. 5:1987;509-522.
19. Poole CA, Ayad S, Gilbert RT. Chondrons from articular cartilage. (V) Immunohistochemical evaluation of type VI collagen organisation in isolated chondrons by light, confocal and electron microscopy. J Cell Sci. 103:1992;1101-1110.
20. Poole C. Articular cartilage chondrons: form, function and failure. J Anat. 191:1997;1-13.
21. Poole CA, Flint MH, Beaumont BW. Chondrons extracted from canine tibial cartilage: preliminary report on their isolation and structure. J Orthop Res. 6:1988;408-419.
22. Lee G, Poole C, Kelley S, Chang J, Caterson B. Isolated chondrons: a viable alternative for studies of chondrocyte metabolism in vitro. Osteoarthritis Cart. 5:1997;261-274.
23. Lee G, Paul T, Slabaugh M, Kelley S. The pericellular matrix is enlarged in osteoarthritic cartilage (abstract). Trans Orthop Res Soc. 22:1997;495.
24. Hauselmann HJ, Fernandes RJ, Mok SS, Schmid TM, Block JA, Aydelotte MB. Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J Cell Sci. 107:1994;17-27.
25. Poole CA, Gilbert RT, Herbage D, Hartmann DJ. Immunolocalisation of type IX collagen in normal and spontaneously osteoarthritic canine tibial cartilage and isolated chondrons. Osteoarthritis Cart. 5:1997;191-204.
26. Jones WR, Ting-Beall HP, Lee GM, Kelley SS, Hochmuth RM, Guilak F. Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. J Biomech. 32:1999;119-127.
27. McDevitt CA, Pahl JA, Ayad S, Miller RR, Uratsuji M, Andrish JT. Experimental osteoarthritic articular cartilage is enriched in guanidine soluble type VI collagen. Biochem Biophys Res Comm. 157:1988;250-255.
28. Ronziere M-C, Ricard-Blum S, Tiollier J, Hartman DJ, Garrone R, Herbage D. Comparative analysis of collagens solubilized from human foetal, and normal and osteoarthritic adult articular cartilage, with emphasis on type VI collagen. Bioch Bioph Acta. 1038:1990;222-230.
29. Kielty CM, Lees M, Shuttleworth CA, Woolley D. Catabolism of intact type VI collagen microfibrils: susceptibility to degradation by serine proteinases. Biochem Bioph Res Comm. 191:1993;1230-1236.