Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver

Toxicological Sciences

Volumn 53, Issue 1, 2000, Pages 145-149

  Thomas, T ^a   Rauscher, F ^a   Sanders, R ^a   Veltman, J ^b   Watkins, J B ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALCON RESEARCH LTD   (United States)

Author keywords

Aldose reductase inhibitors; Catalase; Glutathione reductase; Lipid peroxidation; Reactive oxygen species; Superoxide dismutase

Indexed keywords

AL 4114; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; IMIRESTAT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; RABBIT; RAT;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUORENES; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDANTOINS; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; OXIDOREDUCTASES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SPIRO COMPOUNDS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0033985858     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.1.145     Document Type: Article

References (41)

1. Allen, R. G., and Baiin, A. K. (1989). Oxidative influence on development and differentiation: An overview of a free radical theory of development. Free Rad. Biol. Med. 6, 631-661.
2. Altomare, E., Grattagliano, I., Vendemaile, G., Micelli-Ferrari, T., Signorile, A., and Cardia, L. (1997). Oxidative protein damage in human diabetic eye: evidence of a retinal participation. Eur. J. Clin. Invest. 27, 141-147.
3. Altomare, E., Vendemiale, G., Chicco, D., Procacci, V., and Cinelli, F. (1992). Increased lipid peroxidation in type 2 poorly controlled diabetic patients. Diab. Metab. 18, 264-271.
4. Asahina, T., Kashiwagi, A., Nishio, Y., Ikebuchi, M., Harada, N., Tanaka, Y., Takagi, Y., Saeki, Y., Kikkawa, R., and Shigeta, Y. (1995). Impaired activation of glucose oxidation and NADPH supply in human endothelial cells exposed to H2O2 in high-glucose medium. Diabetes 44, 520-526.
5. Baynes, J.W. (1991). Role of oxidative stress in development of complications of diabetes. Diabetes 40, 405-412.
6. Boel, E., Selmer, J., Flodgaard, H. J., and Jensen, T. (1995). Diabetic late complications: Will aldose-reductase inhibitors or inhibitors of advanced glycosylation end product formation hold promise? J. Diab. Compile. 9, 104-129.
7. Bravi, M. C., Pietrangeli, P., Laurenti, O., Basili, S., Cassone-Faldetta, M., Ferri, C., and DeMattia, G. (1997). Polyol pathway activation and glutathi-one redox status in non-insulin-dependent diabetic patients. Metabolism 46, 1194-1198.
8. Brawn, K., and Fridovich, I. (1980). Superoxide radical and Superoxide dismutase: Threat and defense. Acta. Physiol Scand. Suppl. 492, 9-18.
9. Carlberg, I., and Mannervik, B. (1975). Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 250,5475-5480.
10. Chandler, C. E., and Miller, L. J. (1986). Studies of aldose reductase using neuronal cell culture and ligated rat sciatic nerve. Metabolism 3SS, 71-77.
11. Crapo, J. D., McCord, J. M., and Fridovich, I. (1978). Preparation and assay of Superoxide dismutase. Methods Enzymol. S3, 382-393.
12. Frank, L. (1985). Oxygen toxicity in eukaryotes. In Superoxide Dismutase (L. W. Oberley, Ed.), Vol. 3, pp. 1-44. CRC Press, Boca Raton, FL.
13. Freeman, B. A., and Crapo, J. D. (1982). Biology of disease: free radicals and tissue injury. Lab. Invest. 47, 412-426.
14. Fridovich, I. (1978). The biology of oxygen radicals. Science 201, 875-880.
15. Giugliano, D., and Ceriello, A. (1996). Oxidative stress and diabetic vascular complications. Diabetes Care, 19, 257-267.
16. Halliwell, B., Aeschbach, R., Loliger, J., and Aruoma, O. I. (1995). The characterization of antioxidants. Food Chem. Toxic. 33, 601-617.
17. Hissin, P. J., and Hilf, R. A (1976). A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74,214-226.
18. Kakkar, R., Kalra, J., Mantha, S. V., and Prasad, K. (1995). Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol. Cell Biochem. 151, 113-119.
19. Keyse, S. M., and Tyrrell, R. M. (1989). Heme oxygenase is the major 32-kDa stress protein induced in human fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Nail. Acad. Sci. USA 86, 99-103.
20. Kinoshita, J. H., Datiles, M. B., Kador, P. F., and Robison, W. G. (1990). Aldose reductase and diabetic eye complications. In Diabetes Mellitus Theory and Practice (H. Rifkin and D. Porte, Eds.), pp 264-278. Elsevier, New York.
21. Kiss, A. D., Haggard, K., Veltman, J. C., and Ziegler, D. M. (1992). Oxidation of aldose-reductase inhibitors ALO-4114 and ALO-3152 catalyzed by liver microsomes. Drug Metab. Dispos. 20, 948-953.
22. Lowry, O. H., Rosebrough, N. J., Farr, J. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
23. Luck, H. (1963). Catalase. In Methods of Enzymatic Analysis (H. U. Bergmeyer, Ed.), pp. 885-888. Academic Press, New York.
24. Ludvigson, M. A., and Sorenson, R. L. (1980). Immunohistochemical localization of aldose reductase: II. Rat eye and kidney. Diabetes 29, 450-459.
25. Oberley, L. W. (1988). Free radicals and diabetes. Free Rad. Biol. Med. 5, 113-124.
26. Ohkawa, H. Ohishi, N., and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-337.
27. Petrash, J. M., Tarie, I., Wilson, D. K., and Quiocho, F. A. (1994). Aldose reductase catalysis and crystallography: Insights from recent advances in enzyme structure and function. Diabetes 43, 955-959.
28. Phillips, J. P., Campbell, S. D., Michaud, P., Charbonneau, M., and Hilliker, A. J. (1989). Null mutation of copper/zinc Superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc. Natl. Acad. Sci. U S A 86, 2761-2765.
29. Raskin, P., and Rosenstock, J. (1987). Aldose-reductase inhibitors and diabetic complications. Am. J. Med. 83, 298-306.
30. Reddi, A. S., and Bollinen, J. S. (1997). Renal cortical expression of mRNAs for antioxidant enzymes in normal and diabetic rats. Biochem. Biophys. Res. Commun. 235, 598-601.
31. Reddy, V. N., Lin, L. R., Giblin, F. J., Lou, M., Kador, P. F., and Kinoshita, J. H. (1992). The efficacy of aldose-reductase inhibitors on polyol accumulation in human lens and retinal pigment epithelium in tissue culture. J. Ocular Pharmacol 8, 43-52.
32. Ross, D. (1988). Glutathione, free radicals and chemotherapeutic agents. Mechanism of free radical-induced toxicity and glutathione-dependent protection. Pharmacol. Ther. 37, 231-249.
33. Sastry, S. G., Sanders, R. A., Veltman, J. C., and Watkins, J. B., III. (1995). Minimal effects of two aldose-reductase inhibitors, Al-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits. Drug Aletab. Dispos. 23, 1094-1098.
34. Shull, S., Heintz, N. H., Periasamy, M., Manohar, M., Janssen, Y. M. W., Marsh, J. P., and Mossman, B. T. (1991). Differential regulation of antioxidant enzymes in response to oxidants. J. Biol. Chem. 266, 24398-24403.
35. Spycher, S. E., Tabataba-Vakili, S., O'Donnell, V. B., Palomba, L., and Azzi, A. (1997). Aldose reductase induction: A novel response to oxidative stress of smooth muscle cells. FASEB J. 11, 181-188.
36. Tappel, A. L. (1978). Glutathione peroxidase and hydroperoxides. Methods Enzymol. 52, 506-513.
37. Tomlinson, D. R., Stevens, E. J., and Diemel, L. T. (1994). Aldose-reductase inhibitors and their potential for the treatment of diabetic complications. Trends Pharmacol. Sci. IS, 293-297.
38. Veltman, J. C., Kumar, A., Sanders, R. A., and Watkins, J. B., III. (1998). Comparison of the effects of acute, intraperitoneal versus topical-ocular dosing of aldose-reductase inhibitors on hepatic biotransformation in rabbit and rat. Int. J. Toxicol.17, 603-617.
39. Williamson, J. R., Chang, K., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., van den Enden, M., Kilo, C., and Tilton, R. G. (1993). Hyperglycémie pseudohypoxia and diabetic complications. Diabetes 42, 801-813.
40. Wu, R. R., Lyons, P. A., Wang, A., Sainsbury, A. J., Chung, S., and Palmer, T. N. (1993). Effects of galactose feeding on aldose-reductase gene expression. J. Clin. Invest. 92, 155-159.
41. Yoshioka, T., Homma, T., Meyrick, B., Takeda, M., Moore-Jarrett, T., Kon, V., and Ichikawa, I. (1994). Oxidants induce transcriptional activation of manganese Superoxide dismutase in glomerular cells. Kidney Int. 46, 405-413.