Antinociceptive activity of derivatives of improgran and burimamide

Pharmacology Biochemistry and Behavior

Volumn 65, Issue 1, 2000, Pages 61-66

  Hough, L B ^a   Nalwalk, J W ^a   Leurs, R ^b   Menge, W M P B ^b   Timmerman, H ^b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Analgesia; Antinociception; Histamine; Improgan

Indexed keywords

ANTINOCICEPTIVE AGENT; BURIMAMIDE; CIMETIDINE; HISTAMINE; IMPROGRAN; UNCLASSIFIED DRUG; VUF 4577; VUF 4582; VUF 5393; VUF 5394; VUF 5405; VUF 5407;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TOXICITY;

ANALGESICS, NON-NARCOTIC; ANIMALS; BURIMAMIDE; CIMETIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE H2 ANTAGONISTS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033985821     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00187-2     Document Type: Article

References (18)

1. Appelbaum B.D., Holtzman S.G. Stress-induced changes in the analgesic and thermic effects of morphine induced centrally. Brain Res. 358:1985;303-308.
2. 2-receptor antagonist. J. Int. Med. Res. 3:1975;86-92.
3. Cooper D.G., Young R.C., Durant G.J., Ganellin C.R. Histamine receptors. Comp. Med. Chem. 3:1990;323-421.
4. Crane L.A., Glick S.D. Simple cannula for repeated intracerebral drug administration in rats. Pharmacol. Biochem. Behav. 10:1979;799-800.
5. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-79.
6. 2-receptor antagonist cimetidine. J. Med. Chem. 20:1977;901-906.
7. Eddy N.B., Leimbach D. Synthetic analgesics, II Dithienylbutenyl and dithienylbutylamines. J. Pharmacol. Exp. Ther. 107:1953;385-393.
8. 2-receptor antagonists. Eur. J. Med. Chem. 20:1985;409-413.
9. 3 antagonists and derivatives. J. Pharmacol. Exp. Ther. 283:1997;1534-1543.
10. 125I]-iodophenpropit, to rat brain. Br. J. Pharmacol. 113:1994;355-362.
11. Lamberti C., Bartolini A., Ghelardini C., Malmberg-Aiello P. Investigation into the role of histamine receptors in rodent antinociception. Pharmacol. Biochem. Behav. 53:1996;567-574.
12. Li B.Y., Nalwalk J.W., Barker L.A., Cumming P., Parsons M.E., Hough L.B. Characterization of the antinociceptive properties of cimetidine and a structural analog. J. Pharmacol. Exp. Ther. 276:1996;500-508.
13. Li B.Y., Nalwalk J.W., Finkel J.M., Glick S.D., Hough L.B. SKF92374, a cimetidine analog, produces mechanical and thermal antinociception in the absence of motor impairment. Analgesia. 3:1997;15-20.
14. Li B.Y., Nalwalk J.W., Hough L.B. Effects of naltrexone and histamine antagonists on the antinociceptive activity of the cimetidine analog SKF92374 in rats. Brain Res. 748:1997;168-174.
15. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1988;Academic Press, Sydney.
16. 2 receptors. Proc. Natl. Acad. Sci. USA. 93:1996;6802-6807.
17. 3 receptor antagonists. The effect of chain length variation of the alkyl spacer and modifications of the n-thiourea substituent J. Med. Chem. 38:1995;2244-2250.
18. Vollinga R.C., Menge W.M.P.B., Timmerman H. A new convenient route for the synthesis of 4-(omega-aminoalkyl)-1H-imidazoles. Rec. Trav. Chim. 112:1993;123-125.