Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere

Leukemia

Volumn 14, Issue 1, 2000, Pages 105-111

  Andersen, M K ^a   Pedersen Bjergaard, J ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Alkylating agents; Dicentric chromosomes; Therapy related acute myeloid leukemia; Therapy related myelodysplasia

Indexed keywords

ALKYLATING AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CENTROMERE; CHROMOSOME 1Q; CHROMOSOME 5P; CHROMOSOME 7P; CHROMOSOME G BAND; DICENTRIC CHROMOSOME; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; KARYOTYPE; MAJOR CLINICAL STUDY; MYELODYSPLASIA; PRIORITY JOURNAL; TRISOMY;

EID: 0033984674     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401594     Document Type: Article

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