Quantitative expression of erythropoietin receptor (EPO-R) on acute leukaemia cells: Relationships between the amount of EPO-R and CD phenotypes, in vitro proliferative response, the amount of other cytokine receptors and clinical prognosis

British Journal of Haematology

Volumn 108, Issue 1, 2000, Pages 55-63

  Takeshita, Akihiro ^a   Shinjo, Kaori ^a   Higuchi, Masato ^b   Miyawaki, Shuichi ^c   Takemoto, Yoshinobu ^d   Kishimoto, Yuji ^e   Saito, Kenji ^f   Takuchi, Hirokuni ^g   Kuriyama, Kazutaka ^h   Kimura, Yukihiko ⁱ   Asou, Norio ^j   Takahashi, Masatomo ^k   Hotta, Tomomitu ^l   Kanamaru, Akihisa ^m   Ueda, Ryuzo ⁿ   Ohno, Ryuzo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c SAISEIKAI MAEBASHI HOSPITAL   (Japan)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e KANSAI MEDICAL UNIVERSITY   (Japan)

^f DOKKYO MEDICAL UNIVERSITY   (Japan)

^g KOCHI MEDICAL SCHOOL   (Japan)

^h NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁱ TOKYO MEDICAL UNIVERSITY   (Japan)

^j KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^k ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l TOKAI UNIVERSITY   (Japan)

^m KINKI UNIVERSITY   (Japan)

ⁿ NAGOYA CITY UNIVERSITY   (Japan)

more..

Author keywords

Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Clinical prognosis; Erythropoietin receptor; In vitro response

Indexed keywords

CYTOKINE RECEPTOR; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA REMISSION; MALE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ACUTE DISEASE; ADOLESCENT; ADULT; CELL DIVISION; CYTOKINES; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CYTOKINE; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECEPTORS, THROMBOPOIETIN;

EID: 0033982421     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01828.x     Document Type: Article

References (35)

1. Asano, Y., Okamura, S., Shibuya, T., Harada, M. & Niho, Y. (1988) Growth of clonogenic myeloblastic leukemic cells in the presence of human recombinant erythropoietin in addition to various human recombinant hematopoielic growth factors. Blood, 72, 1682-1686.
2. Bennet, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. & Sultan, C. (1985a) Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). Annals of Internal Medicine, 103, 460-462.
3. Bennet, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. & Sultan, C. (1985b) Proposed revised criteria for the classification of acute leukemia. Annals of Internal Medicine, 103, 620-625.
4. Bergstrom, J. (1993) New aspects of erythropoietin treatment. Journal of Internal Medicine, 233, 445-462.
5. Bowen, D., Culligan, D. & Jacobs, A. (1991) The treatment of anaemia in the myelodysplaslic syndromes with recombinant human erythropoietin. British Journal of Haematology, 77, 419-423.
6. Budel, L.M., Touw, I.P., Delwel, R. & Löwenberg, B. (1989) Granulocyte colony-stimulating factor receptors in human acute myelocylic leukemia. Blood, 74, 1989.
7. Chiba, S., Takahashi, T., Takeshita, K., Minowada, J., Yazaki, Y., Ruddle, F.H. & Hirai, H. (1997) Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Blood, 90, 97-104.
8. D'Andrea, A.D. & Zon, L.I. (1990) Erythropoitin receptor: subunit structure and activation. Journal of Clinical Investigation, 86, 681-687.
9. Dercksen, M.W., Weimar, I.S., Richel, D.J., Breton-Gorius, J., Vainchenker, W., Slaper-Cortenbach, I.C.M., von Pinedo, H.M., dem Borne, A.E.G., Gerritsen, W.R. & van der School, C.E. (1995) The value of flow cytometric analysis of platelet glycoprotein expression on CD34+ cells measured under conditions that prevent P-selectin-mediated binding of platelets. Blood, 86, 3771-3782.
10. Jacobs, K., Shoemaker, C.B., Rundersdorf, R., Neill, S.D., Kaufmann, R.J., Mufson, A., Seehra, J., Jones, S.S., Hewick, R. & Fritsch, E.F. (1985) Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature, 313, 806-810.
11. Jones, S.S., D'Andrea, A.D., Haines, L.L. & Wong, G.G. (1990) Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood, 76, 1990.
12. Kelleher, C., Miyauchi, J., Wong, G., Clark, S., Minden, M.D. & McCulloch, E.A. (1987) Synergism between recombinant growth factors, GM-CSF and G-CSF, acting on the blast cells of acute myeloblastic leukemia. Blood, 69, 1498-1503.
13. Krantz, S.B. (1991) Erythropoietin. Blood, 77, 419-434.
14. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Ishikawa, J., Horokawa, Y., Hashimoto, K., Moriyama, Y., Tsujimura, T., Nishiura, T., Miyazaki, H. & Matsuzawa, Y. (1995) Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood, 86, 703-709.
15. Mitjavila, J.L., Villeval, J.L., Cramer, P., Henri, A., Gasson, J., Krystal, G., Tulliez, M., Berger, R., Breton-Gorius, J. & Vainchenker, W. (1987) Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias. Blood, 70, 965-973.
16. Miyazaki, Y., Kuriyama, K., Higuchi, M., Tsushima, H., Sohda, H., Imai, N., Kondo, T. & Tomonaga, M. (1997) Establishment and characterization of a new erythropoietin-dependent acute myeloid cell line, AS-E2. Leukemia, 11, 1941-1949.
17. Motoji, T., Hoshino, S., Ueda, M., Takanashi, M., Masuda, M., Nakayama, K., Oshimi, K. & Mizoguchi, H. (1990) Enhanced growth of clonogeneic cells from acute myeloblastic leukaemia by erythropoietin. British Journal of Haematology, 75, 60-67.
18. Nakamura, Y., Komatsu, N. & Nakauchi, H. (1994) A truncated erythropoietin receptor and cell death. Science, 264, 588.
19. Scatchard, G.R. (1949) The attractions of proteins for small molecules and ions. Annals of New York Academy of Sciences, 51, 660-672.
20. Shimoda, K., Okamura, S., Harada, N., Ikematsu, W., Kondo, S., Kawasaki, C., Tanaka, T., Etou, T., Akashi, K., Okamura, T., Shibuya, T., Harada, M. & Niho, Y. (1992) Granulocyte colony-stimulating factor receptors on human acute leukemia: biphenotypic leukemic cells possess granulocyte colony-stimulating factor receptors. Cancer Research, 52, 3052-3055.
21. Shinjo, K., Takeshita, A., Ohnishi, K. & Ohno, R. (1995) Expression of granulocyte colony-stimulating factor receptor increases with differentiation in myeloid cells by a newly-devised quantitative flow-cytometric assay. British Journal of Haematology, 91, 783-794.
22. Shinjo, K., Takeshita, A., Ohnishi, K. & Ohno, R. (1996) Quantitative detection of erythropoietin receptors and its decreased expression in myelodysplastic syndromes by a newly-devised flow cytometric assay. British Journal of Haematology, 93, 66.
23. Shinjo, K., Takeshita, A., Higuchi, M., Ohnishi, K. & Ohno, R. (1997a) Quantitative detection of erythropoietin receptors by a newly-devised flow cytometric assay and its expression in bone marrow cells from normal volunteers. British Journal of Haematology, 93, 551-558.
24. Shinjo, K., Takeshita, A., Ohnishi, K. & Ohno, R. (1997b) Granulocyte colony-stimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells. Leukemia and Lymphoma, 25, 37-46.
25. Shinjo, K., Takeshita, A., Nakamura, S., Naito, K., Yanagi, M., Tobita, T., Ohnishi, K. & Ohno, R. (1998) Serum thrombopoietin levels in patients correlate inversely with platelet counts during chemotherapy-induced thrombocytopenia. Leukemia, 12, 295-300.
26. Stein, R.S., Abels, R.I. & Krantz, S.B. (1991) Pharmacologic doses of recombinant human erythropoietin in the treatment of myelodysplastic syndromes. Blood, 78, 1658-1663.
27. Stopka, T., Zivny, J.H., Stopkova, P., Prchal, J.F. & Prchal, J.T. (1998) Human hematopoietic progenitors express erythropoietin. Blood, 91, 3766-3772.
28. Takeshita, A., Shinjo, K., Ohnishi, K. & Ohno, R. (1995) New flow cytometric method for detection of minimally expressed multidrug resistance P-glycoprotein on normal and acute leukaemia cells using biotinylated MRK16 and Streptavidin-RED670 conjugate. Japanese Journal of Cancer Research, 86, 607-615.
29. Takeshita, A., Shinjo, K., Ohnishi, K. & Ohno, R. (1996) Expression of multidrug resistance of P-glycoprotein in myeloid progenitor cells of different phenotype: comparison between normal bone marrow cells and leukaemia cells. British Journal of Haematology, 93, 18-21.
30. Takeshita, A., Shinjo, K., Izumi, M., Pan, L., Nakamura, S., Naito, K., Ohnishi, K. & Ohno, R. (1997) Amount of mpl on bone marrow haemotopoietic precursor cells from healthy volunteers and patients with refractory anaemia. British Journal of Haematology, 99, 746-756.
31. Takeshita, A., Shinjo, K., Izumi, M., Pan, L., Nakamura, S., Naito, K., Ohnishi, K. & Ohno, R. (1998) Quantitative expression of thrombopoietin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. British Journal of Haematology, 100, 283-290.
32. Vellenga, E., Young, D.C., Wagner, K., Wiper, D., Ostapovicsz, D. & Griffin, J.D. (1987) The effect of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblastic leukemia. Blood, 69, 1771-1776.
33. Winkelmann, J.C., Penny, L.A., Deaven, L.L., Forget, B.G. & Jenkins, R.B. (1990) The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. Blood, 76, 24-30.
34. Wollman, Y., Westphal, G., Blum, M., Simatov, R., Blumberg, S., Peer, G., Chernihovsky, T., Friedrich, E. & Iaina, M. (1996) The effect of human recombinant erythropoietin on the growth of a human neuroblastoma cell line. Life Science, 59, 315-322.
35. Young, I.T. (1977) Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources. Journal of Histochemistry and Cytochemistry, 25, 935-941.