Expression of multidrug resistance P-glycoprotein in myeloid progenitor cells of different phenotype: Comparison between normal bone marrow cells and leukaemia cells

British Journal of Haematology

Volumn 93, Issue 1, 1996, Pages 18-21

  Takeshita, Akihiro ^a   Shinjo, Kaori ^a   Ohnishi, Kazunori ^a   Ohno, Ryuzo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

acute myeloid leukaemia (AML); multi drug resistance (MDR); P glycoprotein; phenotype

Indexed keywords

GLYCOPROTEIN P;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTE;

ACUTE DISEASE; ANTIGENS, CD; ANTIGENS, CD34; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BONE MARROW CELLS; DRUG RESISTANCE, MULTIPLE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID; MEMBRANE GLYCOPROTEINS; P-GLYCOPROTEIN; PHENOTYPE;

EID: 0029877305     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.459996.x     Document Type: Article

References (12)

1. Campos, L., Guyotat, D., Archimbaud, E., Oriol, P.C., Tsuruo, T., Troncy, J., Treille, D. & Fiere, D. (1992) Clinical significance of multidrug resistance P-glycoprotein expression on acute non-lymphoblastic leukemia cells at diagnosis. Blood, 79, 473-476.
2. Chaudhary, P.M. & Roninson, I.B. (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell, 66, 85-94.
3. Drach, D., Zhao, S., Drach, J., Mahadevia, R., Gattringer, C., Huber, H. & Andreeff, M. (1992) Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood, 80, 2729-2734.
4. Marie, J.P., Zittoun, R. & Sikic, B.I. (1991) Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlation with treatment outcome and in vitro drug sensitivity. Blood, 78, 586-592.
5. Michieli, M., Damiani, D., Geromin, A., Michelutti, A., Fanin, R., Raspadori, D., Russo, D., Visani, G., Dinota, A., Pileri, S., Tsuruo, T., Grandi, M., Baccarani, M. & Tura, S. (1992) Overexpression of multidrug resistance-associated p-170-glycoprotein in acute non-lymphocytic leukemia. European Journal of Haematology, 48, 87-92.
6. Muller, M.R., Lennarts, K., Nowrousian, R.D., Tsuruo, T., Rajewsky, M.F. & Seeber, S. (1994) Improved flow-cytometric detection of low P-glycoprotein expression in leukemic blasts by histogram subtraction analysis. Cytometry, 15, 64-72.
7. Overton, W.R. (1988) Modified histogram subtraction technique for analysis of flow cytometry data. Cytometry, 9, 619-626.
8. Pirker, R., Wallner, J., Geissler, K., Linkesch, J., Haas, O.A., Bettelheim, P., Hopfner, M., Scherrer, R., Valent, P., Havelec, L., Ludwig, H. & Lechner, K. (1991) MDR1 gene expression and treatment outcome in acute myeloid leukemia. Journal of the National Cancer Institute, 83, 708-712.
9. Sonneveld, P., van Dongen, J.J.M., Hagemeijer, A., van Lom, K., Nooter, K., Schoester, M., Adriaansen, H.J., Tsuruo, T. & de Leeuw, K. (1993) High expression of the multidrug resistance P-glycoprotein in high-risk myelodysplasia is associated with immature phenotype. Leukemia, 7, 963-969.
10. Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S. & Mori, S. (1988) Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK16. Cancer Reserch, 48, 1926-1929.
11. Takeshita, A., Shinjo, K., Ohnishi, K. & Ohno, R. (1995) New flow cytometric method for detection of minimally expressed multidrug resistance P-glycoprotein on normal and acute leukemia cells using biotinylated MRK16 and StreptavidinREd670 conjugate. Japanese Journal of Cancer Reserch, 86, 607-615.
12. + acute myeloid leukemia cells. Blood, 82, 3157-3162.