Immunogenicity of neutralizing epitopes on multiple-epitope vaccines against HIV-1

International Archives of Allergy and Immunology

Volumn 121, Issue 1, 2000, Pages 80-84

  Lu, Yun ^a   Xiao, Yi ^a   Ding, Jian ^a   Dierich, Manfred P ^b   Chen, Ying Hua ^a  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

HIV 1; Immunogenicity; Multiple epitope vaccine; Neutralizing epitope

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 160; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

EID: 0033981135     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024300     Document Type: Article

References (21)

1. Connor RI, Korber BTM, Graham BS, et al: Immunological and virological analyses of persons infected by human-immunodeficiency-virus type-1 while participating in trials of recombinant gp120 subunit vaccines. J Virol 1998;72:1552-1576.
2. Moore JP: Back to primary school. Nature 1995;376:115.
3. Moore JP, Nurton DR: HIV-1 neutralizing antibodies. How full is the bottle? Nature Med 1999;5:142-144.
4. Chen YH, Xiao Y, Yu T, Dierich MP: Epitope vaccine: A new strategy against HIV-1. Immunol Today, in press.
5. Montefiori DC, et al: Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency type 1. J Virol 1998;72:3427-3431.
6. Catasti P, Bradbury EM, Gupta G: Structure and polymorphism of HIV-1 third variable loops. J Biol Chem 1995;271:8236-8242.
7. Emini EA, Schleif WA, Nunberg JH, et al: Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody. Nature 1992;355:728-730.
8. Chen YH, Dierich MP: A common epitope on gp41, IFN-α and IFN-β induces protective activity. Immunol Today 1998;19:586-587.
9. Muster T, Steindl F, Purtscher M, et al: A conserved neutralizing epitope on gp41 of human immunodeficiency virus type I. J Virol 1993; 67:6642-6647.
10. Purtscher M, Trkola A, Gruber G, et al: A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1994;10:1651-1658.
11. Purtscher M, Trkola A, Grassauer A, et al: Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5. AIDS 1996;10:587-593.
12. Shafferman A, Jahrling PB, Benveniste RE, et al: Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences. Proc Natl Acad Sci USA 1991;88:7126-7130.
13. Chan DC, Fass D, Berger JM, et al: Core structure of gp41 from the HIV envelope glycoprotein. Cell 1997;89:263-273.
14. Weissenhorn W, Dessen A, Harrison SC, et al: Atomic structure of the ectodomain from HIV-1 gp41. Nature 1997;387:426-443.
15. LaCasse RA, Follis KE, Trahey M, et al: Fusion-competent vaccines: Broad neutralization of primary isolates of HIV. Science 1999; 283:357-362.
16. Chong P, Chan N, Kandil A, et all: A strategy for rational design of fully synthetic glycopeptide conjugate vaccines. Infect Immun 1997; 65:4918-4925.
17. Chen YH, Ebenbichler C, Vornhagen R, et al: HIV-1 gp41 contains two sites for interaction with several proteins on the helper T-lymphoid cell line, H9. AIDS 1992;6:533-539.
18. Cher YH, Christiansen A, Bock G, Dierich MP: HIV-2 transmembrane protein gp36 like HIV-1 gp41 binds to human lymphocytes and monocytes. AIDS 1995;9:1193-1194.
19. Henderson LA, Qureshi MN: A peptide inhibitor of human immunodeficiency virus infection binds to novel human cell surface polypeptides. J Biol Chem 1993;268:15291-15297.
20. Chen YH, et al: The C domain of HIV-1 gp41 binds the putative cellular receptor protein P62. AIDS, in press.
21. Chen YH, Dierich MP: Identification of a second site in HIV-1 gp41 mediating binding to cells. Immunol Lett 1996;52:153-156.