메뉴 건너뛰기




Volumn 88, Issue 1, 2000, Pages 205-216

Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia. The Israel National Study Report

Author keywords

Central nervous system prophylaxis; Childhood acute lymphoblastic leukemia treatment; Extended triple intrathecal

Indexed keywords

ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; FOLINIC ACID; HYDROCORTISONE; MERCAPTOPURINE; METHOTREXATE; VINCRISTINE;

EID: 0033979535     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(20000101)88:1<205::AID-CNCR28>3.0.CO;2-7     Document Type: Article
Times cited : (11)

References (62)
  • 1
    • 0028282876 scopus 로고
    • Prevention and treatment of meningeal leukemia in children
    • Pinkel D, Woo S. Prevention and treatment of meningeal leukemia in children. Blood 1994;84:355-66.
    • (1994) Blood , vol.84 , pp. 355-366
    • Pinkel, D.1    Woo, S.2
  • 2
    • 0020083673 scopus 로고
    • Sanctuary therapy: A randomized trial of 724 children with previously untreated acute lymphoblastic leukemia
    • A report from the Children's Cancer Study Group
    • Nesbit ME, Sather H, Robison LL, Donaldson M, Littman P, Ortega JA, et al. Sanctuary therapy: a randomized trial of 724 children with previously untreated acute lymphoblastic leukemia. A report from the Children's Cancer Study Group. Cancer Res 1982;42:674-80.
    • (1982) Cancer Res , vol.42 , pp. 674-680
    • Nesbit, M.E.1    Sather, H.2    Robison, L.L.3    Donaldson, M.4    Littman, P.5    Ortega, J.A.6
  • 3
    • 0027497166 scopus 로고
    • Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital
    • Rivera GK, Pinkel D, Simone JV, Hancock ML, Crist WM. Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital. N Engl J Med 1993;329:1289-95.
    • (1993) N Engl J Med , vol.329 , pp. 1289-1295
    • Rivera, G.K.1    Pinkel, D.2    Simone, J.V.3    Hancock, M.L.4    Crist, W.M.5
  • 4
    • 0037481855 scopus 로고
    • Therapy related central nervous system diseases in children with acute lymphocytic leukemia
    • Mastrangelo R, Poplack DG, Riccardi R, editors. Martinus Nijhoff Publishers
    • Price RA. Therapy related central nervous system diseases in children with acute lymphocytic leukemia. In: Mastrangelo R, Poplack DG, Riccardi R, editors. Central nervous system leukemia: prevention and treatment. Martinus Nijhoff Publishers, 1983:71-81.
    • (1983) Central Nervous System Leukemia: Prevention and Treatment , pp. 71-81
    • Price, R.A.1
  • 5
    • 0021126662 scopus 로고
    • Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia
    • Tiberin P, Maor E, Zaizov R, Cohen IJ, Hirsch M, Yosefovich T, et al. Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. J Neurosurg 1984;61:772-6.
    • (1984) J Neurosurg , vol.61 , pp. 772-776
    • Tiberin, P.1    Maor, E.2    Zaizov, R.3    Cohen, I.J.4    Hirsch, M.5    Yosefovich, T.6
  • 6
    • 0024554381 scopus 로고
    • Neurotoxicity due to central nervous system therapy for childhood leukemia
    • Ochs JJ. Neurotoxicity due to central nervous system therapy for childhood leukemia. Am J Pediatr Hematol Oncol 1989;11:93-105.
    • (1989) Am J Pediatr Hematol Oncol , vol.11 , pp. 93-105
    • Ochs, J.J.1
  • 7
    • 0019506529 scopus 로고
    • Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation
    • Meadows AT, Gordon J, Massari DJ, Littman P, Fegusson J, Moss Karen. Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation. Lancet 1981;2:1015-8.
    • (1981) Lancet , vol.2 , pp. 1015-1018
    • Meadows, A.T.1    Gordon, J.2    Massari, D.J.3    Littman, P.4    Fegusson, J.5    Karen, M.6
  • 9
    • 0018818464 scopus 로고
    • Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukaemia
    • Green DM, Freeman AI, Sather HN, Sallen SE, Nesbit ME, Cassady JR, et al. Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukaemia. Lancet 1980;1:1398-402.
    • (1980) Lancet , vol.1 , pp. 1398-1402
    • Green, D.M.1    Freeman, A.I.2    Sather, H.N.3    Sallen, S.E.4    Nesbit, M.E.5    Cassady, J.R.6
  • 10
    • 0019905743 scopus 로고
    • Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: A Pediatric Oncology Group study
    • Sullivan MP, Chen T, Dyment PG, Hvizdala E, Steuber P. Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: a Pediatric Oncology Group study. Blood 1982;60:948-58.
    • (1982) Blood , vol.60 , pp. 948-958
    • Sullivan, M.P.1    Chen, T.2    Dyment, P.G.3    Hvizdala, E.4    Steuber, P.5
  • 11
    • 0031013471 scopus 로고    scopus 로고
    • Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: A ten-year follow-up
    • Freeman AI, Boyett JM, Glicksman AS, Brecher ML, Leventhal BG, Sinks LF, et al. Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: a ten-year follow-up. Med Pediatr Oncol 1997;28: 98-107.
    • (1997) Med Pediatr Oncol , vol.28 , pp. 98-107
    • Freeman, A.I.1    Boyett, J.M.2    Glicksman, A.S.3    Brecher, M.L.4    Leventhal, B.G.5    Sinks, L.F.6
  • 13
    • 0029084654 scopus 로고
    • CNS chemoradiotherapy of childhood leukemia: The plot thickens but the ending bodes well
    • Bleyer A. CNS chemoradiotherapy of childhood leukemia: the plot thickens but the ending bodes well [editorial]. J Clin Oncol 1995;13:2480-2.
    • (1995) J Clin Oncol , vol.13 , pp. 2480-2482
    • Bleyer, A.1
  • 14
    • 0343895107 scopus 로고
    • Successful central nervous system prophylaxis without radiotherapy in childhood acute lymphoblastic leukemia (ALL): Israel National Studies (INS 1984, 1989)
    • Büchner et al., editors. Berlin: Springer-Verlag
    • Stark B, Abramov A, Attias D, Balin A, Barak Y, Goshen Y, et al. Successful central nervous system prophylaxis without radiotherapy in childhood acute lymphoblastic leukemia (ALL): Israel National Studies (INS 1984, 1989). In: Büchner et al., editors. Acute leukemias IV. Prognostic factors. Berlin: Springer-Verlag, 1994;359-65.
    • (1994) Acute Leukemias IV. Prognostic Factors , pp. 359-365
    • Stark, B.1    Abramov, A.2    Attias, D.3    Balin, A.4    Barak, Y.5    Goshen, Y.6
  • 15
    • 0007773261 scopus 로고    scopus 로고
    • Extended intrathecal triple therapy for preventing CNS relapse in non very high risk childhood acute lymphoblastic leukemia treated with the Israeli studies INS-84 and INS-89 (modified BFM 86)
    • Stark B, Abramov A, Attias D, Balin A, Burstein Y, Chividalli G, et al. Extended intrathecal triple therapy for preventing CNS relapse in non very high risk childhood acute lymphoblastic leukemia treated with the Israeli Studies INS-84 and INS-89 (modified BFM 86) [abstract 1087]. Proc Am Soc Clin Oncol 1996;15:367.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 367
    • Stark, B.1    Abramov, A.2    Attias, D.3    Balin, A.4    Burstein, Y.5    Chividalli, G.6
  • 17
    • 0021814622 scopus 로고
    • Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia
    • Niemeyer CM, Hitchcock-Bryan S, Sallan SE. Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia. Semin Oncol 1985;12:122-30.
    • (1985) Semin Oncol , vol.12 , pp. 122-130
    • Niemeyer, C.M.1    Hitchcock-Bryan, S.2    Sallan, S.E.3
  • 18
    • 0023249618 scopus 로고
    • Controversies in the management of childhood acute lymphoblastic leukemia: Treatment intensification, CNS leukemia, and prognostic factors
    • Rivera GK, Mauer AM. Controversies in the management of childhood acute lymphoblastic leukemia: treatment intensification, CNS leukemia, and prognostic factors. Semin Hematol 1987;24:12-26.
    • (1987) Semin Hematol , vol.24 , pp. 12-26
    • Rivera, G.K.1    Mauer, A.M.2
  • 19
    • 0023854188 scopus 로고
    • Modified BFM therapy for children with previously untreated acute lymphoblastic leukemia and unfavorable prognostic features
    • Report of Children's Cancer Study Group Study CCG-193P.
    • Gaynon PS, Bleyer WA, Steinherz PG, Finklestein JZ, Littman PS, Miller DR, et al. Modified BFM therapy for children with previously untreated acute lymphoblastic leukemia and unfavorable prognostic features. Report of Children's Cancer Study Group Study CCG-193P. Am J Pediatr Hematol Oncol 1988;10:42-50.
    • (1988) Am J Pediatr Hematol Oncol , vol.10 , pp. 42-50
    • Gaynon, P.S.1    Bleyer, W.A.2    Steinherz, P.G.3    Finklestein, J.Z.4    Littman, P.S.5    Miller, D.R.6
  • 20
    • 0028152851 scopus 로고
    • Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients, results and conclusions of the multicenter trial ALL-BFM 86
    • Reiter A, Schrappe M, Ludwig W-D, Hiddenmann W, Sauter S, Henze G, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients, Results and conclusions of the multicenter trial ALL-BFM 86. Blood 1994;84:3122-33.
    • (1994) Blood , vol.84 , pp. 3122-3133
    • Reiter, A.1    Schrappe, M.2    Ludwig, W.-D.3    Hiddenmann, W.4    Sauter, S.5    Henze, G.6
  • 21
    • 0022918904 scopus 로고
    • Methotrexate infusions in poor prognosis acute lymphoblastic leukemia in children: I. The norwegian methotrexate study in acute lymphoblastic leukemia in childhood, August 1975-December 1980
    • Moe PJ, Seip M, Finne H, Kolmannskog S. Methotrexate infusions in poor prognosis acute lymphoblastic leukemia in children: I. The Norwegian methotrexate study in acute lymphoblastic leukemia in childhood, August 1975-December 1980. Med Pediatr Oncol 1986;14:187-8.
    • (1986) Med Pediatr Oncol , vol.14 , pp. 187-188
    • Moe, P.J.1    Seip, M.2    Finne, H.3    Kolmannskog, S.4
  • 22
    • 0023258836 scopus 로고
    • 2 in children with acute lymphoblastic leukemia
    • 2 in children with acute lymphoblastic leukemia. Cancer 1987; 60:5-13.
    • (1987) Cancer , vol.60 , pp. 5-13
    • Borsi, J.D.1    Moe, P.J.2
  • 23
    • 0023944389 scopus 로고
    • Efficacy of high dose methotrexate in childhood acute lymphocytic leukemia: Analysis by contemporary risk classifications
    • Abromowitch M, Ochs J, Pui C-H, Fairclough D, Murphy SB, Rivera GK. Efficacy of high dose methotrexate in childhood acute lymphocytic leukemia: analysis by contemporary risk classifications. Blood 1988;71:866-9.
    • (1988) Blood , vol.71 , pp. 866-869
    • Abromowitch, M.1    Ochs, J.2    Pui, C.-H.3    Fairclough, D.4    Murphy, S.B.5    Rivera, G.K.6
  • 24
    • 0029978292 scopus 로고    scopus 로고
    • A randomized phase-III study of the efficacy of granulocyte colony-stimulating factors in children with high-risk acute lymphoblastic leukemia
    • Welte K, Reiter A, Mempel K, Pfetsch M, Schwab G, Schrappe M, et al. A randomized Phase-III study of the efficacy of granulocyte colony-stimulating factors in children with high-risk acute lymphoblastic leukemia. Blood 1996;87:3143-50.
    • (1996) Blood , vol.87 , pp. 3143-3150
    • Welte, K.1    Reiter, A.2    Mempel, K.3    Pfetsch, M.4    Schwab, G.5    Schrappe, M.6
  • 26
    • 0023201962 scopus 로고
    • Total body irradiation and high-dose etoposide: A new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies
    • Blume KG, Forman SJ, O'Donnell MR, Doroshow JH, Krance RA, Nademanee AP, et al. Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies. Blood 1987;69:1015-20.
    • (1987) Blood , vol.69 , pp. 1015-1020
    • Blume, K.G.1    Forman, S.J.2    O'Donnell, M.R.3    Doroshow, J.H.4    Krance, R.A.5    Nademanee, A.P.6
  • 27
    • 0017162163 scopus 로고
    • Proposals for the classification of the acute leukemias. French-American-British (FAB) co-operative group
    • Bennet JM, Catovsky D, Daniel MT, Flandrin G, Glaton DAG, Gralnick HR, et al. Proposals for the classification of the acute leukemias. French-American-British (FAB) co-operative group. Br J Haematol 1976;33:451-8.
    • (1976) Br J Haematol , vol.33 , pp. 451-458
    • Bennet, J.M.1    Catovsky, D.2    Daniel, M.T.3    Flandrin, G.4    Glaton, D.A.G.5    Gralnick, H.R.6
  • 28
    • 0027303092 scopus 로고
    • Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia
    • Pui C-H, Behm FG, Crist WM. Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia [review article]. Blood 1993;82:343-62.
    • (1993) Blood , vol.82 , pp. 343-362
    • Pui, C.-H.1    Behm, F.G.2    Crist, W.M.3
  • 29
    • 0029934173 scopus 로고    scopus 로고
    • Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies
    • Rothe G, Schmitz G, Adorf D, Barlage S, Gramatzki M, Hanenberg H, et al. Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. Leukemia 1996;10:877-95.
    • (1996) Leukemia , vol.10 , pp. 877-895
    • Rothe, G.1    Schmitz, G.2    Adorf, D.3    Barlage, S.4    Gramatzki, M.5    Hanenberg, H.6
  • 30
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 31
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer One-mother Rep 1966;50:163-70.
    • (1966) Cancer One-mother Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 33
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox DR. Regression models and life tables. J R Stat Soc 1972;34:187-220.
    • (1972) J R Stat Soc , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 34
    • 0343895105 scopus 로고
    • Effective CNS protection in ALL without and with reduced cranial irradiation in four BFM trials
    • Schrappe M, Reiter A, Henze G, Graf N, Niemeyer C, Riehm H. Effective CNS protection in ALL without and with reduced cranial irradiation in four BFM trials [abstract O-26]. Med Pediatr Oncol 1995;25:240.
    • (1995) Med Pediatr Oncol , vol.25 , pp. 240
    • Schrappe, M.1    Reiter, A.2    Henze, G.3    Graf, N.4    Niemeyer, C.5    Riehm, H.6
  • 35
    • 17144452253 scopus 로고    scopus 로고
    • Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone
    • Conter V, Schrappe M, Aricó M, Reiter A, Rizzari C, Dördelmann M, et al. Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. J Clin Oncol 1997;15: 2786-91.
    • (1997) J Clin Oncol , vol.15 , pp. 2786-2791
    • Conter, V.1    Schrappe, M.2    Aricó, M.3    Reiter, A.4    Rizzari, C.5    Dördelmann, M.6
  • 36
    • 0031879085 scopus 로고    scopus 로고
    • Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Shuster JJ, Wacker P, Pullen J, Humbert J, Land VJ, Mahoney DH Jr., et al. Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group study. J Clin Oncol 1998;16:2854-63.
    • (1998) J Clin Oncol , vol.16 , pp. 2854-2863
    • Shuster, J.J.1    Wacker, P.2    Pullen, J.3    Humbert, J.4    Land, V.J.5    Mahoney D.H., Jr.6
  • 38
    • 0029080839 scopus 로고
    • Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy
    • Conter V, Aricó M, Valsecchi MG, Rizzari C, Testi AM, Messina C, et al. Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. J Clin Oncol 1995;13:2497-502.
    • (1995) J Clin Oncol , vol.13 , pp. 2497-2502
    • Conter, V.1    Aricó, M.2    Valsecchi, M.G.3    Rizzari, C.4    Testi, A.M.5    Messina, C.6
  • 39
    • 0027477488 scopus 로고
    • Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: Comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: A Children's Cancer Group report
    • Tubergen DG, Gilchrist GS, O'Brien RT, Coccia PF, Sather HN, Waskerwitz MJ, et al. Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: a Children's Cancer Group report. J Clin Oncol 1993;11:520-26.
    • (1993) J Clin Oncol , vol.11 , pp. 520-526
    • Tubergen, D.G.1    Gilchrist, G.S.2    O'Brien, R.T.3    Coccia, P.F.4    Sather, H.N.5    Waskerwitz, M.J.6
  • 40
    • 0031887690 scopus 로고    scopus 로고
    • Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: A report from the Children's Cancer Group
    • Nachman J, Sather HN, Cherlow JM, Sensel MG, Gaynon PS, Lukens JN, et al. Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group. J Clin Oncol 1998;16:920-30.
    • (1998) J Clin Oncol , vol.16 , pp. 920-930
    • Nachman, J.1    Sather, H.N.2    Cherlow, J.M.3    Sensel, M.G.4    Gaynon, P.S.5    Lukens, J.N.6
  • 41
    • 0029960017 scopus 로고    scopus 로고
    • High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group
    • Veerman AJP, Hählen K, Kamps WA, Van Leeuwen EF, De Vaan GAM, Solbu G, et al. High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: results of protocol ALL VI from the Dutch Childhood Leukemia Study Group. J Clin Oncol 1996;14:911-8.
    • (1996) J Clin Oncol , vol.14 , pp. 911-918
    • Veerman, A.J.P.1    Hählen, K.2    Kamps, W.A.3    Van Leeuwen, E.F.4    De Vaan, G.A.M.5    Solbu, G.6
  • 42
    • 0032545976 scopus 로고    scopus 로고
    • Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia
    • Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui C-H, et al. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 1998;338:499-505.
    • (1998) N Engl J Med , vol.338 , pp. 499-505
    • Evans, W.E.1    Relling, M.V.2    Rodman, J.H.3    Crom, W.R.4    Boyett, J.M.5    Pui, C.-H.6
  • 43
    • 0030034467 scopus 로고    scopus 로고
    • Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate
    • Masson E, Relling MV, Synold TW, Lui Q, Schuetz JD, Sandlund JT, et al. Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. J Clin Invest 1996;97:73-80.
    • (1996) J Clin Invest , vol.97 , pp. 73-80
    • Masson, E.1    Relling, M.V.2    Synold, T.W.3    Lui, Q.4    Schuetz, J.D.5    Sandlund, J.T.6
  • 44
    • 0024551691 scopus 로고
    • Central nervous system pharmacology of antileukemic drugs
    • Balls FM, Poplack DG. Central nervous system pharmacology of antileukemic drugs. Am J Pediatr Hematol Oncol 1989;11:74-86.
    • (1989) Am J Pediatr Hematol Oncol , vol.11 , pp. 74-86
    • Balls, F.M.1    Poplack, D.G.2
  • 46
    • 0029962417 scopus 로고    scopus 로고
    • Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia
    • Matherly LH, Taub JW. Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia. Leukemia Lymphoma 1996;21:359-68.
    • (1996) Leukemia Lymphoma , vol.21 , pp. 359-368
    • Matherly, L.H.1    Taub, J.W.2
  • 47
    • 0024544745 scopus 로고
    • Evidence of CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue
    • Thyss A, Milano G, Etienne MC, Paquis P, Roche JL, Grelier P, et al. Evidence of CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue. Br J Cancer 1989;59:627-30.
    • (1989) Br J Cancer , vol.59 , pp. 627-630
    • Thyss, A.1    Milano, G.2    Etienne, M.C.3    Paquis, P.4    Roche, J.L.5    Grelier, P.6
  • 48
    • 0025789017 scopus 로고
    • How much is too much? Folinic acid rescue dose in children with acute lymphoblastic leukaemia
    • Borsi JD, Wesenberg F, Stokland T, Moe PJ. How much is too much? Folinic acid rescue dose in children with acute lymphoblastic leukaemia. Eur J Cancer 1991;27:1006-9.
    • (1991) Eur J Cancer , vol.27 , pp. 1006-1009
    • Borsi, J.D.1    Wesenberg, F.2    Stokland, T.3    Moe, P.J.4
  • 49
    • 0029000499 scopus 로고
    • Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia
    • Mahoney DH Jr., Camitta BM, Leventhal BG, Shuster JJ, Civin CJ, Ganick DJ, et al. Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. Cancer 1995;75:2623-31.
    • (1995) Cancer , vol.75 , pp. 2623-2631
    • Mahoney D.H., Jr.1    Camitta, B.M.2    Leventhal, B.G.3    Shuster, J.J.4    Civin, C.J.5    Ganick, D.J.6
  • 50
    • 0344542098 scopus 로고    scopus 로고
    • Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: An association with intermediate-dose intravenous methotrexate and intrathecal triple therapy - A Pediatric Oncology Group study
    • Mahoney DH Jr., Shuster JJ, Nitschke R, Lauer SJ, Steuber CP, Winick N, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy - a Pediatric Oncology Group study. J Clin Oncol 1998;16:1712-22.
    • (1998) J Clin Oncol , vol.16 , pp. 1712-1722
    • Mahoney D.H., Jr.1    Shuster, J.J.2    Nitschke, R.3    Lauer, S.J.4    Steuber, C.P.5    Winick, N.6
  • 51
    • 0031829417 scopus 로고    scopus 로고
    • Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia
    • Rubnitz JE, Relling MV, Harrison PL, Sandlund JT, Ribeiro RC, Rivera GK, et al. Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia. Leukemia 1998;12:1176-81.
    • (1998) Leukemia , vol.12 , pp. 1176-1181
    • Rubnitz, J.E.1    Relling, M.V.2    Harrison, P.L.3    Sandlund, J.T.4    Ribeiro, R.C.5    Rivera, G.K.6
  • 52
    • 0025881351 scopus 로고
    • A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, 24-Gy, or no cranial irradiation
    • Mulhern RK, Fairclough D, Ochs J. A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, 24-Gy, or no cranial irradiation. J Clin Oncol 1991;9:1348-56.
    • (1991) J Clin Oncol , vol.9 , pp. 1348-1356
    • Mulhern, R.K.1    Fairclough, D.2    Ochs, J.3
  • 53
    • 0028020598 scopus 로고
    • Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer
    • Butler RW, Hill JM, Steinherz PG, Meyers PA, Finlay JI. Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer. J Clin Oncol 1994;12:2621-9.
    • (1994) J Clin Oncol , vol.12 , pp. 2621-2629
    • Butler, R.W.1    Hill, J.M.2    Steinherz, P.G.3    Meyers, P.A.4    Finlay, J.I.5
  • 54
    • 0029739176 scopus 로고    scopus 로고
    • Neuropsychologic effects of chemotherapy on children with cancer: A longitudinal study
    • Copeland DR, Moore BD III, Francis DJ, Jaffe N, Culbert SJ. Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. J Clin Oncol 1996;14:2826-35.
    • (1996) J Clin Oncol , vol.14 , pp. 2826-2835
    • Copeland, D.R.1    Moore B.D. III2    Francis, D.J.3    Jaffe, N.4    Culbert, S.J.5
  • 55
    • 0030987072 scopus 로고    scopus 로고
    • Studies of cerebral blood flow in children with acute lymphoblastic leukemia: Case reports of six children treated with methotrexate examined by single photon emission computed tomography
    • Österlundh G, Bjure J, Lannering B, Kjellmer I, Uvebrant P, Ildikó M. Studies of cerebral blood flow in children with acute lymphoblastic leukemia: case reports of six children treated with methotrexate examined by single photon emission computed tomography. J Pediatr Hematol Oncol 1997; 19:28-34.
    • (1997) J Pediatr Hematol Oncol , vol.19 , pp. 28-34
    • Österlundh, G.1    Bjure, J.2    Lannering, B.3    Kjellmer, I.4    Uvebrant, P.5    Ildikó, M.6
  • 56
    • 0030944285 scopus 로고    scopus 로고
    • Secondary acute myelogenous leukemia following safe exposure to etoposide
    • Stine KC, Saylors RL, Sawyer JR, Bewcton DL. Secondary acute myelogenous leukemia following safe exposure to etoposide. J Clin Oncol 1997;15:1583-6.
    • (1997) J Clin Oncol , vol.15 , pp. 1583-1586
    • Stine, K.C.1    Saylors, R.L.2    Sawyer, J.R.3    Bewcton, D.L.4
  • 57
    • 0029927179 scopus 로고    scopus 로고
    • True histiocytic lymphoma following therapy for lymphoblastic neoplasms
    • Soslow RA, Davis RE, Warnke RA, Cleary ML, Kamel OW. True histiocytic lymphoma following therapy for lymphoblastic neoplasms. Blood 1996;87:5207-12.
    • (1996) Blood , vol.87 , pp. 5207-5212
    • Soslow, R.A.1    Davis, R.E.2    Warnke, R.A.3    Cleary, M.L.4    Kamel, O.W.5
  • 58
    • 0031424212 scopus 로고    scopus 로고
    • Primitive neuroectodermal tumor of bone as a second malignant neoplasm in a child previously treated for acute lymphoblastic leukemia
    • Antillon F, Kaste SC, Jenkins JJ, Shurtleff SA, Merchant TE, Downing JR, et al. Primitive neuroectodermal tumor of bone as a second malignant neoplasm in a child previously treated for acute lymphoblastic leukemia. J Pediatr Hematol Oncol 1997;19:473-6.
    • (1997) J Pediatr Hematol Oncol , vol.19 , pp. 473-476
    • Antillon, F.1    Kaste, S.C.2    Jenkins, J.J.3    Shurtleff, S.A.4    Merchant, T.E.5    Downing, J.R.6
  • 59
    • 0026079804 scopus 로고
    • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia
    • Pui C-H, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, et al. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 1991;325:1682-7.
    • (1991) N Engl J Med , vol.325 , pp. 1682-1687
    • Pui, C.-H.1    Ribeiro, R.C.2    Hancock, M.L.3    Rivera, G.K.4    Evans, W.E.5    Raimondi, S.C.6
  • 61
    • 0025097850 scopus 로고
    • Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pre-treated with low doses of methotrexate
    • Lorico A, Boiocchi M, Rappa G, Sen S, Erba E, D'Incalci M. Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pre-treated with low doses of methotrexate. Int J Cancer 1990; 45:156-62.
    • (1990) Int J Cancer , vol.45 , pp. 156-162
    • Lorico, A.1    Boiocchi, M.2    Rappa, G.3    Sen, S.4    Erba, E.5    D'Incalci, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.