A novel Leishmania infantum recombinant antigen which elicits interleukin 10 production by peripheral blood mononuclear cells of patients with visceral leishmaniasis

Infection and Immunity

Volumn 68, Issue 2, 2000, Pages 630-636

  Suffia, Isabelle ^a   Ferrua, Bernard ^a   Stien, Xavier ^c   Mograbi, Baharia ^b   Marty, Pierre ^a   Rousseau, Deborah ^a   Fragaki, Konstantina ^a   Kubar, Joanna ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b INSERM   (France)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; INTERLEUKIN 10; NUCLEAR PROTEIN; PROTOZOAL PROTEIN;

AMASTIGOTE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA LIBRARY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; PARASITE IMMUNITY; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN ELECTROPHORESIS; PROTEIN ISOLATION; VACCINATION; VISCERAL LEISHMANIASIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CLONING, MOLECULAR; FEMALE; IMMUNE SERA; INTERLEUKIN-10; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; RABBITS; RECOMBINANT PROTEINS;

EID: 0033979228     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.2.630-636.2000     Document Type: Article

References (61)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Alvar, J., C. Canavate, B. Gutierrez-Solar, M. Jimenez, F. Laguna, R. Lopez-Velez, R. Molina, and J. Moreno. 1997. Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin. Microbiol. Rev. 10:298-319.
3. Bacellar, O., C. Brodskyn, J. Guerreiro, M. Barral-Netto, C. H. Costa, R. L. Coffman, W. D. Johnson, and E. M. Carvalho. 1996. Interleukin-12 restores interferon-γ production and cytotoxic responses in visceral leishmaniasis. J. Infect. Dis. 173:1515-1518.
4. Badaro, R., T. C. Jones, J. M. Carvalho, D. Sampaio, S. G. Reed, A. Barral, R. Teixeira, and W. D. Johnson. 1986. New perspectives on a subclinical form of visceral leishmaniasis. J. Infect. Dis. 154:1003-1011.
5. Barral-Netto, M., C. Brodskyn, E. M. Carvalho, and A. Barral. 1998. Human_leishmaniasis@cytokines.bahia.br. Braz. J. Med. Biol. Res. 31:149-155.
6. Bogdan, C., Y. Vodovotz, and C. Nathan. 1991. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1549-1555.
7. Bomfim, G., C. Nascimiento, J. Costa, E. M. Carvalho, M. Barral-Netto, and A. Barral. 1996. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Exp. Parasitol. 88:188-194.
8. Campos-Neto, A., L. Soong, J. L. Cordova, D. Sant'Angelo, Y. A. W. Skeiky, N. H. Ruddle, S. G. Reed, C. Janeway, and D. McMahon-Pratt. 1995. Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages. J. Exp. Med. 182:1423-1433.
9. Carvalho, E. M., O. Bacellar, C. Brownell, T. Regis, R. L. Coffman, and S. G. Reed. 1994. Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis. J. Immunol. 152:5949-5956.
10. Carvalho, E. M., R. Badaro, S. G. Reed, T. C. Jones, and W. D. Johnson. 1985. Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J. Clin. Investig. 76:2066-2069.
11. Carvalho, E. M., R. S. Teixeira, and W. D. Johnson. 1981. Cell-mediated immunity in American visceral leishmaniasis: reversible immunosuppression during acute infection. Infect. Immun. 33:498-502.
12. Crowe, J. S., H. J. Cooper, M. A. Smith, M. J. Sims, D. Parker, and D. Gewert. 1991. Improved cloning efficiency of polymerase chain reaction (PCR) products after proteinase K digestion. Nucleic Acids Res. 19:184.
13. Cunha, F. Q., S. Moncada, and F. W. Liew. 1992. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem. Biophys. Res. Commun. 182:1155-1159.
14. Del Prete, G., M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150:353-360.
15. Desjeux, P., and UNAIDS. 1998. Leishmania and HIV in gridlock. Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland.
16. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by human monocytes. J. Exp. Med. 174:1209-1220.
17. Dillon, D. C., G. H. Day, J. A. Whittle, A. J. Magill, and S. G. Reed. 1995. Characterization of a Leishmania tropica antigen that detects immune responses in Desert Storm viscerotropic leishmaniasis patients. Proc. Natl. Acad. Sci. USA 92:7981-7985.
18. Elassad, A. M. S., S. A. Younis, M. Siddig, J. Grayson, E. Petersen, and H. W. Ghalib. 1994. The significance of blood levels of IgM, IgA, IgG and IgG subclasses in Sudanese visceral leishmaniasis patients. Clin. Exp. Immunol. 95:294-299.
19. Fernandes, O., V. K. Murthy, U. Kurath, W. M. Degrave, and D. A. Campbell. 1994. Mini-exon gene variation in human pathogenic Leishmania species. Mol. Biochem. Parasitol. 66:261-271.
20. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
21. Gazzinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol. 148:1792-1796.
22. Ghalib, H. W., M. R. Piuvezam, Y. A. W. Skeiky, M. Siddig, F. A. Hashim, A. M. El-Hassan, D. M. Russo, and S. G. Reed. 1993. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J. Clin. Investig. 92:324-329.
23. Gurunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186:1137-1147.
24. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon-γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59-72.
25. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015.
26. Holaday, B. J., M. M. de Lima Pompeu, T. Evans, D. N. de Melo Braga, M. J. Texeira, A. de Queiroz Sousa, M. D. Sadick, A. W. Vasconcelos, J. S. Abrams, R. D. Pearson, and R. M. Locksley. 1993. Correlates of Leishmania-specific immunity in the clinical spectrum of infection with Leishmania chagasi. J. Infect. Dis. 167:411-417.
27. Holaday, B. J., M. M. de Lima Pompeu, S. Jeronimo, M. J. Texeira, A. de Queiroz Sousa, A. W. Vasconcelos, R. D. Pearson, J. S. Abrams, and R. M. Locksley. 1993. Potential role for interleukin-10 in the immunosuppression associated with kalar azar. J. Clin. Investig. 92:2625-2632.
28. Howard, M., and A. O'Garra. 1992. Biological properties of interleukin 10. Immunol. Today 13:198-200.
29. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421-423.
30. Karp, C. L., S. H. El-Safi, T. A. Wynn, M. M. H. Satti, A. M. Kordofani, F. A. Hashim, M. Hag-Ali, F. A. Neva, T. B. Nutman, and D. L. Sacks. 1993. In vivo cytokine profiles in patients with kalar-azar. Marked elevation of both interleukin-10 and interferon-gamma. J. Clin. Investig. 91:1644-1648.
31. Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
32. + T-lymphocyte counts. AIDS 12:2147-2153.
33. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
34. Marty, P., A. Lelièvre, J. F. Quaranta, A. Rahal, M. Gari-Toussaint, and Y. Le Fichoux. 1994. Use of the leishmanin skin test and Western blot analysis for epidemiological studies in visceral leishmaniasis areas: experience in a highly endemic focus in Alpes-Maritimes (France). Trans. R. Soc. Trop. Med. Hyg. 88:658-659.
35. McMahon-Pratt, D., D. Rodriguez, J.-R. Rodriguez, Y. Zhang, K. Manson, C. Bergman, L. Rivas, J. F. Rodriguez, K. L. Lohman, N. H. Ruddle, and M. Esteban. 1993. Recombinant vaccinia viruses expressing GP46/M-2 protect against Leishmania infection. Infect. Immun. 61:3351-3359.
36. Millesimo, M., M. Zucca, P. Caramello, and D. Savoia. 1996. Evaluation of the immune response in visceral leishmaniasis. Diagn. Microbiol. Infect. Dis. 26:7-11.
37. Murray, H. W., B. Y. Rubin, and C. D. Rothermel. 1983. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. J. Clin. Investig. 72:1506-1510.
38. Oswald, I. P., R. T. Gazzinelli, A. Sher, and S. L. James. 1992. IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J. Immunol. 148:3578-3582.
39. Oswald, I. P., T. A. Wynn, A. Sher, and S. L. James. 1992. IL-10 inhibits macrophage microbicidal activity by blocking the endogenous production of TNF-α required as a costimulatory factor for IFN-γ induced activation. Proc. Natl. Acad. Sci. USA 89:8676-8680.
40. Pampiglione, S., P. E. C. Manson-Bahr, M. La Placa, M. A. Borgatti, and S. Musumeci. 1975. Studies in Mediterranean leishmaniasis. 3. The leishmanin skin test in kala-azar. Trans. R. Soc. Trop. Med. Hyg. 69:60-68.
41. Pearson, R. D., and A. de Queiroz Sousa. 1995. Clinical spectrum of leishmaniasis. Clin. Infect. Dis. 22:1-13.
42. Quijada, L., J. M. Requena, M. Soto, and C. Alonso. 1996. During canine viscero-cutaneous leishmaniasis the anti-Hsp70 antibodies are specifically elicited by the parasite protein. Parasitologia 112:277-284.
43. Ralph, P., I. Nakoinz, A. Sampson-Johannes, S. Fong, D. Lowe, H. Min, and L. Lin. 1992. 1L-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J. Immunol. 148:808-814.
44. Reed, S. G., W. G. Shreffler, J. M. Burns, J. M. Scott, M. G. Orge, H. W. Ghalib, M. Siddig, and R. Badaro. 1990. An improved serodiagnostic procedure for visceral leishmaniasis. Am. J. Trop. Med. Hyg. 43:632-639.
45. Ribeiro-de-Jesus, A., R. P. Almeida, H. Lessa, O. Bacellar, and E. M. Carvalho. 1998. Cytokine profile and pathology in human leishmaniasis. Braz. J. Med. Biol. Res. 31:143-148.
46. Rousseau, D., Y. Le Fichoux, X. Stien, I. Suffia, B. Ferrua, and J. Kubar. 1997. Progression of visceral lesihmaniasis due to Leishmania infantum in BALB/c mice is markedly slowed by prior infection with Trichinella spiralis. Infect. Immun. 65:4978-4983.
47. Rousseau, D., I. Suffia, B. Ferrua, P. Philip, Y. Le Fichoux, and J. Kubar. 1998. Prolonged administration of dexamethasone induces limited reactivation of visceral leishmaniasis in chronically infected BALB/c mice. Eur. Cytokine Netw. 9:655-661.
48. Sacks, D. L., S. L. Lal, S. N. Shrivastava, J. Blackwell, and F. A. Neva. 1987. An analysis of T cell responsiveness in Indian kala-azar. J. Immunol. 138: 908-913.
49. Sambrook, J., E. F. Frilsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
50. Schnur, L. F., and R. L. Jacobson. 1987. Parasitological techniques, p. 516-518. In W. Peters and R. Killick-Kendrick (ed.), The leishmaniasis in biology and medicine. Academic Press Ltd., London, United Kingdom.
51. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. IL-10 and IFN-γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169-174.
52. Sjölander, A., T. M. Baldwin, J. M. Curtis, and E. Handman. 1998. Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis. J. Immunol. 160:3949-3957.
53. Skeiky, Y. A. W., D. R. Benson, J. A. Guderian, J. A. Whittle, O. Bacelar, E. M. Carvalho, and S. G. Reed. 1995. Immune responses of leishmaniasis patients to heat shock proteins of Leishmania species and humans. Infect. Immun. 63:4105-4114.
54. Skeiky, Y. A. W., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Kubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527-1537.
55. Soto, M., J. M. Requena, L. C. Gomez, I. Navarrete, and C. Alonso. 1992. Molecular characterization of a Leishmania donovani infantum antigen identified as histone H2A. Eur. J. Biochem. 205:211-216.
56. Suffia, I., J. F. Quaranta, M. C. M. Eulalio, B. Ferrua, P. Marty, Y. Le Fichoux, and J. Kubar. 1995. Human T-cell activation by 14- and 18-kilo-dalton nuclear proteins of Leishmania infantum. Infect. Immun. 63:3765-3771.
57. Vouldoukis, I., P. A. Bécherel, V. Riveros-Moreno, M. Arock, O. da Silva, P. Debré, D. Mazier, and M. D. Mossalayi. 1997. Interleukin-10 and interleukin-4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation. Eur. J. Immunol. 27:860-865.
58. Webb, J. R., A. Campos-Neto, P. J. Ovendale, T. I. Martin, E. J. Stromberg, R. Badaro, and S. G. Reed. 1998. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infect. Immun. 66:3279-3289.
59. Webb, J. R., D. Kaufmann, A. Campos-Neto, and S. G. Reed. 1996. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. J. Immunol. 157:5034-5041.
60. Wilson, M. E., B. M. Young, K. Paetz Andersen, J. V. Weinstock, A. Metwali, K. M. Ali, and J. E. Donelson. 1995. A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice. Infect. Immun. 63:2062-2069.
61. Xu, D., and F. Y. Liew. 1995. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 84:173-176.