Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin: Application to a pharmacokinetic-pharmacodynamic study in rats

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 738, Issue 1, 2000, Pages 67-73

  Zuideveld, Klaas P ^a   Treijtel, Nicoline ^a   Van Der Graaf, Piet H ^a,b   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

5 HT1A receptors; 8 Hydroxy 2 (di n propylamino)tetralin; Pharmacokinetics

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; SEROTONIN 1A AGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROCHEMICAL DETECTION; ENANTIOMER; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; TECHNIQUE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BODY TEMPERATURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; KINETICS; LINEAR MODELS; MALE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEROTONIN AGONISTS; STEREOISOMERISM;

EID: 0033972290     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00493-4     Document Type: Article

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