Pentoxifylline attenuates hypoxic-ischemic brain injury in immature rats

Pediatric Research

Volumn 47, Issue 1, 2000, Pages 73-78

  Eun, Baik Lin ^a   Liu, Xiao Hong ^b,c   Barks, John D E ^b  

^a Korea University Ansan Hospital   (South Korea)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOXIFYLLINE; PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; MEDIATOR RELEASE; NEUROPROTECTION; NEWBORN; NEWBORN SURGERY; NONHUMAN; PREOPERATIVE CARE; PRIORITY JOURNAL; PROPHYLAXIS; RAT;

EID: 0033971868     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200001000-00014     Document Type: Article

References (54)

1. Barks JD, Silverstein FS 1992 Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury. Brain Pathol 2:235-243
2. Palmer C 1995 Hypoxic-ischemic encephalopathy: therapeutic approaches against microvascular injury, and role of neutrophils, PAF and free radicals. Clin Perinatol 22:481-517
3. Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, Towfighi J 1997 The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res 41:607-616
4. Ivacko JA, Sun R, Silverstein FS 1996 Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats. Pediatr Res 39:39-47
5. Ohno M, Aotani H, Shimada M 1995 Glial responses to hypoxic/ischemic encephalopathy in neonatal rat cerebrum. Dev Brain Res 84:294-298
6. Hagan P, Poole S, Bristow AF, Tilders F, Silverstein FS 1996 Intracerebral NMDA injection stimulates production of interleukin-1 beta in perinatal rat brain. J Neurochem 67:2215-2218
7. Szaflarski J, Burtrum D, Silverstein FS 1995 Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats. Stroke 26:1093-1100
8. Martin D, Chinookoswong N, Miller G 1994 The interleukin-1 receptor antagonist (rhIL-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemia. Exp Neurol 130:362-367
9. Liu XH, Eun BL, Silverstein FS, Barks JDE 1996 The platelet-activating factor antagonist BN 52021 attenuates hypoxic-ischemic brain injury in the immature rat. Pediatr Res 40:797-803
10. Muller R 1981 Hemorheology and peripheral vascular diseases: a new therapeutic approach. J Med 12:209-235
11. Porter JM, Cutler BS, Lee BY, Reich T, Reichle FA, Scogin JT, Strandness DE 1982 Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am Heart J 104:66-72
12. Hood SC, Moher D, Barber CG 1996 Management of intermittent claudication with pentoxifylline: meta-analysis of randomized controlled trials. Can Med Assoc J 155:1053-1059
13. Stricter RM, Remick DG, Ward PA, Spengler RN, Lynch JP, Larrick J, Kunkel SL 1988 Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun 155:1230-1236
14. Chao CC, Hu S, Close K, Choi CS, Molitor TW, Novick WJ, Peterson PK 1992 Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis 166:847-853
15. Ollivier V, Ternisien C, Vu T, Hakim J, de Prost D 1993 Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes. FEBS Lett 322:231-234
16. Leclerc NE, Haan-Archipoff G, Lenoble M, Beretz A 1995 Inhibitors of phosphodiesterase (pentoxifylline, trequinsin) inhibit apical and subcellular matrix expression of tissue factor in cultured human endothelial cells. J Cardiovasc Pharmacol 25(suppl 2):S88-S91
17. Adams Jr JG, Dhar A, Shukla SD, Silver D 1995 Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. J Vasc Surg 21:742-749
18. Sullivan GW, Carper HT, Novick Jr WJ, Mandell GL 1988 Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun 56:1722-1729
19. Zheng H, Crowley JJ, Chan JC, Hoffmann H, Hatherill JR, Ishizaka A, Raffin TA 1990 Attenuation of tumor necrosis factor-induced endothelial cell cytotoxicity and neutrophil chemiluminescence. Am Rev Respir Dis 142:1073-1078
20. Mandell GL 1995 Cytokines, phagocytes, and pentoxifylline. J Cardiovasc Pharmacol 25(suppl 2):S20-S22
21. Fujimoto K, Yoshida S, Moriyama Y, Sakaguchi T 1976 Absorption, distribution, excretion, and metabolism of 1-(5-oxohexyl) theobromine (BL 191) in rats. Chem Pharm Bull (Tokyo) 24:1137-1145
22. Shohami E, Bass R, Wallach D, Yamin A, Gallily R 1996 Inhibition of tumor necrosis factor alpha (TNFα) activity in rat brain is associated with cerebroprotection after closed head injury. J Cereb Blood Flow Metab 16:378-384
23. Hong JH, Chiang CS, Campbell IL, Sun JR, Withers HR, McBride WH 1995 Induction of acute phase gene expression by brain irradiation. Int J Radiat Oncol Biol Phys 33:619-626
24. Nataf S, Louboutin JP, Chabannes D, Feve JR, Muller JY 1993 Pentoxifylline inhibits experimental allergic encephalomyelitis. Acta Neurol Scand 88:97-99
25. Bluhm RE, Molnar J, Cohen MM 1985 The effect of pentoxifylline on the energy metabolism of ischemic gerbil brain. Clin Neuropharmacol 8:280-285
26. Hartmann JF, Becker RA, Cohen MM 1977 Effects of pentoxifylline on cerebral ultrastructure of normal and ischemic gerbils. Neurology 27:77-84
27. Toung TJ, Kirsch JR, Maruki Y, Traystman RJ 1994 Effects of pentoxifylline on cerebral blood flow, metabolism, and evoked response after total cerebral ischemia in dogs. Crit Care Med 22:273-281
28. Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Takeda H, Yokoyama M 1995 Pentoxifylline ameliorates postischemic delayed hypoperfusion of the cerebral cortex following cardiac arrest in cats. J Neurol Sci 132:105-109
29. Steen PA, Milde JH, Michenfelder JD 1982 Pentoxifylline in regional cerebral ischemia in cats. Acta Anaesthesiol Scand 26:39-43
30. Krause PJ, Maderazo EG, Contrino J, Eisenfeld L, Herson VC, Greca N, Bannon P, Kreutzer DL 1991 Modulation of neonatal neutrophil function by pentoxifylline. Pediatr Res 29:123-127
31. Newton JA, Ashwood ER, Yang KD, Augustine NH, Hill HR 1989 Effect of pentoxifylline on developmental changes in neutrophil cell surface mobility and membrane fluidity. J Cell Physiol 140:427-431
32. Barks JD, Post M, Tuor UI 1991 Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat. Pediatr Res 29:558-563
33. Dobbing J, Sands J 1979 Comparative aspects of the brain growth spurt. Early Hum Dev 3:79-83
34. Romijn HJ, Hofman MA, Gramsbergen A 1991 At what age is the developing cerebral cortex of the rat comparable to that of the full-term human baby? Early Hum Dev 26:61-67
35. Mcllwain H, Bachelard HS 1985 Chemical and enzymatic makeup of the brain during development and ageing. In: Mcllwain H, Bachelard HS (eds) Biochemistry and the Central Nervous System. Churchill Livingstone, Edinburgh, pp 371-412
36. Trescher WH, Lehman RA, Vannucci RC 1990 The influence of growth retardation on perinatal hypoxic-ischemic brain damage. Early Hum Dev 21:165-173
37. Honess DJ, Dennis IF, Bleehen NM 1993 Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice. Radiother Oncol 28:208-218
38. Rocci Jr ML, Luke DR, Saccar CL 1987 Pharmacokinetics of pentoxifylline during concomitant theophylline administration to rats. Pharm Res 4:433-435
39. Rice JE, Vannucci RC, Brierley JB 1981 The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9:131-141
40. McDonald JW, Roeser NF, Silverstein FS, Johnston MV 1989 Quantitative assessment of neuroprotection against NMDA-induced brain injury. Exp Neurol 106:289-296
41. Andine P, Thordstein M, Kjellmer I, Nordborg C, Thiringer K, Wennberg E, Hagberg H 1990 Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia. J Neurosci Meth 35:253-260
42. Hagberg H, Gilland E, Bona E, Hanson LÅ, Hahn-Zoric M, Blennow M, Holst M, McRae A, Söder O 1996 Enhanced expression of interleukin (IL)-1 and IL-6 messenger RNA and bioactive protein after hypoxia-ischemia in neonatal rats. Pediatr Res 40:603-609
43. Bessler H, Gilgal R, Djaldetti M, Zahavi I 1986 Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J Leukoc Biol 40:747-754
44. Rosenblum WI, Shimizu T, Nelson GH 1993 Interaction of endothelium with dilation produced by inhibitors of cyclic nucleotide diesterases in mouse brain arterioles in vivo. Stroke 24:266-270
45. Hakim J 1995 Pharmacologic control of intracellular signaling pathways: from research to therapy. J Cardiovasc Pharmacol 25(suppl 2)S106-S113
46. Salyer JL, Bohnsack JF, Knape WA, Shigeoka AO, Ashwood ER, Hill HR 1990 Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration. Am J Pathol 136:831-841
47. Willette RN, Shiloh AO, Sauermelch CF, Sulpizio A, Michell MP, Cieslinski LB, Torphy TJ, Ohlstein EH 1997 Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors. J Cereb Blood Flow Metab 17:210-219
48. Bowton DL, Stump DA, Prough DS, Toole JF, Lefkowitz DS, Coker L 1989 Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. Stroke 20:1662-1666
49. Johansson BB 1986 Pentoxifylline: cerebral blood flow and glucose utilization in conscious spontaneously hypertensive rats. Stroke 17:744-747
50. Rudman D, Fleischer A, Kutner MH 1976 Concentration of 3′,5′ cyclic adenosine monophosphate in ventricular cerebrospinal fluid of patients with prolonged coma after head trauma or intracranial hemorrhage. N Engl J Med 295:635-638
51. Mujsce DJ, Christensen MA, Vannucci RC 1990 Cerebral blood flow and edema in perinatal hypoxic-ischemic brain damage. Pediatr Res 27:450-453
52. Haul R, Schurer L, Schmid-Schonbein GW, del Zoppo GJ 1996 Experimental antileukocyte interventions in cerebral ischemia. J Cereb Blood Flow Metab 16:1108-1119
53. Lauterbach R, Pawlik D, Kowalczyk D, Ksycinski W, Helwich E, Zembala M 1999 Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Crit Care Med 27:807-814
54. Hoffman H, Markewitz A, Kreuzer E, Reichen K, Jochum M, Faist E 1998 Pentoxifylline decreases the incidence of multiple organ failure in patients after major cardio-thoracic surgery. Shock 9:235-240